BACKGROUND: Anthracycline-induced cardiotoxicity (AIC) remains the main long-term and irreversible side effect in malignancy
Abstract
BACKGROUND: Anthracycline-induced cardiotoxicity (AIC) remains the main long-term and irreversible side effect in malignancy survivors. Cardiotoxicity prevention is one of most reasonable attitudes.
AIM: To verify whether ramipril is able to protect from early-onset AIC in prospective randomized open-label study.
METHODS: Women with breast cancer (BC) were randomized to ramipril (RA) or control arm (CA). Data from 96 women, median age 47 years, without significant cardiovascular diseases, post-breast surgery and eligible for adjuvant anthracyclines, was analyzed. Cardiotoxicity was estimated with repeated echocardiography, troponin I and NT-proBNP levels over one-year follow-up. AIC was defined as a decrease in left ventricular ejection fraction (LVEF) and/or biomarkers elevation and/or occurrence of heart failure (HF) or cardiac death.
RESULTS: LVEF decrease ˃10 percent points occurred in 6.3% in RA vs 18.5% in controls (P = 0.15). No cases of HF, cardiac death or LVEF decline below ˂50% were reported. Percentage of patients with NT-proBNP elevation increased with time in CA (P = 0.003), whereas it remained unchanged in RA. At the end of observation, more patients in CA showed NTproBNP increase and fewer NT-proBNP decline (P = 0.01). No significant difference in troponin levels was found between the study arms. Ramipril was well tolerated in normotensive women.
CONCLUSIONS: In relatively young BC women without serious co-morbidities, who underwent anthracycline therapy, one year treatment with ramipril exerts potentially protective effect on the cardiotoxicty assessed with NT-proBNP, however its efficacy in long-term follow-up needs further investigations.
PMID: 31995035 [PubMed - as supplied by publisher]
12:31
Photo
Not included, change data exporting settings to download.
256×256, 6.0 KB
12:31
In reply to this message
pubmed: ctoall&ca or conall
LncRNA OIP5-AS1 promotes the development of esophageal squamous cell carcinoma by binding to miR-1297.
Related Articles
LncRNA OIP5-AS1 promotes the development of esophageal squamous cell carcinoma by binding to miR-1297.
Panminerva Med. 2020 Jan 24;:
Authors: Wang L, Ren X, Ma X, Yin L, Niu X, Xing S
PMID: 31992030 [PubMed - as supplied by publisher]
12:31
Photo
Not included, change data exporting settings to download.
256×256, 6.0 KB
12:31
In reply to this message
pubmed: ctoall&ca or conall
Major cardiac events for adult survivors of childhood cancer diagnosed between 1970 and 1999: report from the Childhood Cancer Survivor Study cohort.
//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--highwire.stanford.edu-icons-externalservices-pubmed-bmj_full.gif //www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--highwire.stanford.edu-icons-externalservices-pubmed-bmjjournals_open_access.gif Related Articles
Major cardiac events for adult survivors of childhood cancer diagnosed between 1970 and 1999: report from the Childhood Cancer Survivor Study cohort.
BMJ. 2020 01 15;368:l6794
Authors: Mulrooney DA, Hyun G, Ness KK, Ehrhardt MJ, Yasui Y, Duprez D, Howell RM, Leisenring WM, Constine LS, Tonorezos E, Gibson TM, Robison LL, Oeffinger KC, Hudson MM, Armstrong GT
Comments
Post a Comment
اكتب تعليق حول الموضوع