Azarga

Azarga الاسم التجاري

العلمي الاسم Timolol maleate, brinzolamide

وصــــــف الـــــــدواء

Glaucoma

قطرات العين تحتوي على تيمولول وبرينزولامايد هذه الأدوية التي تقلل ارتفاع الضغط داخل

العين.

يتم الاحتفاظ عادة بالضغط داخل مقلة العين بواسطة استمرار تدفق السائل المائي يسمى

النكتة من خلال مقلة العين. ويتم إنتاج الخلط المائي من قبل جزء من العين يسمى الجسم

الهدبي. إذا تراكم الخلط المائي داخل مقلة العين٬ هذا يزيد من الضغط داخل مقلة العين. هذا

الضغط يجب أن يتم تخفيضه٬ وإلا يمكن ان يسبب تلف العصب البصري ويضعف الرؤية.

الدواء يعمل بطرق مختلفة للحد من إنتاج الخلط المائي ويؤدي الى انخفاض تراكمه داخل

مقلة العين. كلاهما بالتالي يقلل الضغط في مقلة العين.

تيمولول هو من حاصرات بيتا. هذه الأدوية تمنع مستقبلات بيتا في أجزاء مختلفة من

الجسم. منع المستقبلات بيتا في العين يقلل من كمية الخلط المائي الذي يتم انتاجه.

برينزولامايد هو نوع من الادوية تسمى مثبطات أنزيم الكربونيك أنهايدريز. وهو يعمل عن

طريق إعاقة عمل هذا الانزيم في الجسم و هو عادة مسؤول عن إنتاج الملح يسمى

بيكربونات في الجسم. وهناك حاجة للبيكربونات في إنتاج الخلط المائي. من خلال خفض

الانتاج من بيكربونات٬ برينزولامايد يقلل أيضا من إنتاج الخلط المائي.

وتستخدم قطرات العين لعلاج الجلوكوما عندما يكون العلاج مع قطرة العين حاصرات بيتا من

تلقاء نفسها لا يخفض الضغط في العين بما فيه الكفاية.

الاستخدامات

ارتفاع الضغط في العين

فتح زاوية الزرق

Therapeutic Indication

Decrease of intraocular pressure (IOP) in adult patients with open-angle glaucoma or ocular hypertension for whom monotherapy provides insufficient IOP reduction.

What is Azarga?

Azarga is a medicine that contains two active substances, brinzolamide and timolol. It is available as eye drops.

What is Azarga used for?

Azarga is used to reduce intra-ocular pressure (IOP, pressure inside the eye). It is used in adults with open-angle glaucoma (a disease where the pressure in the eye rises because fluid cannot drain out of the eye) or ocular hypertension (when the pressure in the eye is higher than normal). Azarga is used when treatment with a medicine containing only one active substance has been tried but has not reduced the IOP sufficiently.

The medicine can only be obtained with a prescription.

How is Azarga used?

Azarga is given as one drop into the affected eye(s) twice a day. The suspension needs to be shaken well before use. If it is used with another eye medicine, the different medicines should be used at least 5 minutes apart. If the other eye medicine is an eye ointment it should be used last.

How does Azarga work?

Raised IOP causes damage to the retina (the light-sensitive surface at the back of the eye) and to the optic nerve that sends signals from the eye to the brain. This can result in serious vision loss and even blindness. By lowering the pressure, Azarga reduces the risk of damage.

Azarga contains two active substances, brinzolamide and timolol. The two substances work by reducing the production of the aqueous humour (the watery fluid in the eye) in different ways. Brinzolamide is a carbonic anhydrase inhibitor that works by blocking an enzyme called carbonic anhydrase, which produces bicarbonate ions in the body. Bicarbonate is required for the production of the aqueous humour. Brinzolamide has been authorised in the European Union (EU) as Azopt since 2000. Timolol is a beta blocker that has been commonly used to treat glaucoma since the 1970s. The combination of the two active substances has an additive effect, reducing the pressure inside the eye more than either medicine alone.

How has Azarga been studied?

Azarga has been studied in two main studies involving a total of 960 adults with open-angle glaucoma or ocular hypertension. The first was a six-month study comparing Azarga with brinzolamide and with timolol used on their own in 523 patients. The second was a 12-month study comparing Azarga with the combination of timolol and dorzolamide (another carbonic anhydrase inhibitor) in 437 patients. In both studies, the main measure of effectiveness was the change in IOP over the first six months of treatment. IOP was measured in ‘millimetres of mercury’ (mmHg).

What benefit has Azarga shown during the studies?

Azarga was more effective than either of the active substances used alone and was as effective as the combination of timolol and dorzolamide. In the first study, IOP fell from around 21 mmHg by 8.0 to 8.7 mmHg in the patients using Azarga. This compared with 5.1 to 5.6 mmHg in those using brinzolamide and 5.7 to 6.9 mmHg in those using timolol. In the second study, IOP had fallen from around 26 mmHg by around 8.3 mmHg after six months in both groups of patients.