High dose melphalan is commonly used as a conditioning regimen for autologous stem cell transplantation in multiple

 

Abstract

High dose melphalan is commonly used as a conditioning regimen for autologous stem cell transplantation in multiple myeloma. There are reports of adverse cardiac events with melphalan manifested by supraventricular tachycardia and atrial fibrillation. Here, we report a rare case of a 58 year old female with multiple myeloma, who developed sinus arrest after autologous stem cell transplantation using high dose melphalan as a conditioning regimen. It was severe and rare, therefore, monitoring for cardiac toxicity in patients receiving high-dose melphalan is mandatory.

PMID: 32190351 [PubMed]

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pubmed: ctoall&ca or conall

miR-140-5p mediates bevacizumab-induced cytotoxicity to cardiomyocytes by targeting the VEGFA/14-3-3γ signal pathway.

miR-140-5p mediates bevacizumab-induced cytotoxicity to cardiomyocytes by targeting the VEGFA/14-3-3γ signal pathway.

Toxicol Res (Camb). 2019 Nov 01;8(6):875-884

Authors: Chen XY, Huang WL, Peng XP, Lv YN, Li JH, Xiong JP