Theresa M. Schwab, MD
Key Points
• Rapid-sequence intubation (RSI) is the preferred method
for endotracheal tube placement in the emergency
department.
• The decision to intubate should always be made on
clinical grounds. Time permitting, assess for factors
predictive of a difficult airway before RSI.
INTRODUCTION
Successful airway management depends on the prompt
recognition of an inadequate airway, the identification of
risk factors that may impair successful bag-valve-mask
(BVM) ventilation or endotracheal t ube (ETT) placement,
and the use of an appropriate technique to properly secure
the airway. The decision to intubate is a clinical one and
should be based on the presence of any 1 of 3 major conditions: an inability to successfully protect one's airway
against aspiration/occlusion, an inability to successfully
oxygenate the blood (hypoxemia), or an inability to successfully clear the respiratory byproducts of cellular
metabolism (hypercapnia). Additional indications including the desire to decrease the work of breathing (sepsis),
the need for therapeutic hyperventilation (increased intracranial pressure [ICP]), and the need to obtain diagnostic
imaging in noncooperative individuals (altered mental
status) should be taken into account on a patient-bypatient basis.
Techniques for the management of unstable airways
range from basic shifts in patient positioning to invasive
surgical intervention. Standard basic life support recommendations such as the head-tilt chin-lift maneuver may
open a previously occluded airway. Oropharyngeal and
nasal airway adjuncts are both simple to use and highly
37
• General criteria for endotracheal intubation include a
failure to protect the airway, a failure to adequately
oxygenate, and a fa ilure to expire accumulating co r
• Pursue alternative techniques (eg, cricothyrotomy) in
patients when the in itial airway intervention has fa iled
and the patient cannot be adequately ventilated.
effective in this setting, but are unfortunately often underutilized. Failure to respond to these measures warrants the
placement of an ETT. Rapid-sequence intubation (RSI)
combines the careful use of pretreatment interventions with
the administration of induction and paralytic agents to create the ideal environment for ETT placement and is the
preferred method in the emergency department (ED).
A patient who cannot be intubated within 3 attempts is
considered a failed airway. This scenario occurs in -3-5%
of all cases. Numerous alternative devices including laryn
geal mask airways (LMA), introducer bougies, and fiberoptic instruments have been developed to facilitate airway
management in these situations. That said, these methods
are not failsafe, and roughly 0.6% of patients will require a
surgical airway. Emergent cricothyrotomy is the preferred
surgical technique for most ED patients.
CLINICAL PRESENTATION
.... History
The need for immediate airway intervention in emergency
situations always supersedes the need for a comprehensive
history and physical exam. Time permitting, perform a
rapid airway assessment to identify any risk factors predictive of a difficult airway, inquire about any current
CHAPTER 11
medication use and known drug allergies, and try to ascertain the immediate events leading up to ED presentation.
Risk factors predictive of a difficult airway include
those that impair adequate BVM ventilation and those that
preclude successful placement of an ETT. Examples of the
former include patients with facial trauma and distorted
anatomy, obese patients with excessive cervical soft t issue,
and asthmatic patents with excessively high airway resistances. Examples of the latter include patients with a his
tory of degenerative changes of the spine that limit cervical
mobility ( eg, rheumatoid arthritis, ankylosing spondylitis),
patients with underlying head and neck cancers that distort the normal cervical anatomy, and those with excessive
swelling of the airway and surrounding tissues (eg,
angioedema).
..... Physical Examination
Rapidly examine the airways of all critically ill patients.
Always consider the presence of concurrent cervical spine
injury in victims of trauma and immobilize as appropriate.
Carefully examine the face, noting any signs of significant
facial trauma and the presence of a beard, both of which
frequently impair adequate BVM ventilation. Inspect the
oropharynx, noting the presence of dentures; the size of
the teeth and presence of a significant overbite; visibility of
the soft palate, uvula, and tonsillar pillars (ie, Mallampati
classification); and the presence of significant airway swelling. The pooling of blood or secretions in the oropharynx
indicates an inability to properly protect the airway. A good
adage to remember when assessing the airway is the 3-3-2
rule. The inability to open the mouth 3 finger breaths, a
distance from the tip of the chin to the base of the neck less
than 3 finger breaths, or a distance between the mandibular floor and the prominence of the thyroid cartilage of less
than 2 finger breaths all predict more difficult ETT place
ment. Assess the range of motion of the cervical spine,
provided there is no concern for occult injury.
DIAGNOSTIC STUDIES
..... Laboratory
Although abnormalities on either blood gas analysis (hypercapnia) or pulse oximetry (hypoxemia) may be indicative of
an inadequate airway, normal values on either of these studies should not j ustify the delay of definitive intervention in
the appropriate clinical scenario. Progressive abnormalities
on serial testing (increasing PaC02
, decreasing Pa02
) in
patients who are clinically decompensating indicates the
need for airway intervention.
..... Imaging
Imaging studies should not be used to predict the need for
airway intervention. Obtain a chest x-ray (CXR) in all
patients after intubation to confirm proper ETT placement.
The tip of the ETT should be visualized approximately
2 em above the carina. Deeper insertion results in placement into the right mainstem bronchus.
MEDICAL DECISION MAKING
Consider all rapidly reversible causes of airway compromise
(eg, hypoglycemia, opioid overdose) before pursuing endotracheal intubation. Proper intervention may transform a
comatose patient with a rather tenuous airway into an awake
coherent individual with adequate airway protection.
Identify patients who are likely to present a difficult airway
and those who require specialized approaches ( eg, head
trauma precautions, hypotension, cervical spine injury) and
proceed accordingly (Figure 1 1-1).
PROCEDURES
..... Bag-Valve-Mask Ventilation
Proper BVM ventilation requires an open airway and an
airtight seal between the mask and the patient's face. Use
the head-tilt chin-lift technique (jaw-thrust maneuver in
trauma victims) to open the airway and insert oropharyngeal or nasal adjuncts as necessary to maintain patency.
Avoid the use of oral adjuncts in patients with intact gag
reflexes and nasal adjuncts in patients with significant
mid-face trauma. With proper technique and a high-flow
oxygen source, this method can provide an Fi02 of
approximately 90% ( Figure 1 1-2).
..... Rapid-Sequence Intubation
Preoxygenate all patients with a high-flow oxygen source
(eg, nonrebreather [NRB] mask) for several minutes as
time permits before RSI. Avoid positive pressure ventilation
(eg, BVM) to prevent insufflation of the stomach, which
can increase the patient's risk for aspiration. Use this time
to prepare and check your equipment. Ensure adequate N
access and proper function of the suction device. Remove
patient dentures, significant loose teeth, and any oral debris.
Choose the appropriate size ETT. Tube sizes range in diameter from 2.5-9 mm. A size 7.5- or 8.0-mm tube is appropriate for most adult female and male patients respectively.
Inflate the balloon to check for leaks and insert a stylet.
Uncuffed ETTs have been historically preferred in patients
younger than 8 years of age as the narrowest portion of
their airways lies inferior to the vocal cords at the level of
the cricoid ring. That said, most practitioners now prefer
cuffed ETTs for all patients. To determine the appropriate
size of the ETT in pediatric patients, either use the formula
Size = (Age/4) + 4 for uncuffed tubes or (Age/4) + 3 for the
cuffed variety, or use a tube that is equal in diameter to the
child's fifth finger .
Check the light on your laryngoscope blade to ensure
that it works. Laryngoscope blades range in size from 0-4
and come in 2 major varieties. The Macintosh blade is
curved in shape and meant to indirectly lift the epiglottis
away from the vocal cords. It is also designed with a special
AIRWAY MANAGEMENT
Airway management indicated:
Failure to oxygenate, venti late, or
protect the airway
Rapid airway eva luation to identify
findings indicative of a difficult airway
Difficult airway
predicted
No difficult airway
predicted
Modified approach including:
• "Awake look" intubation
• Difficult airway adjuncts
(LMA, bougie, fiberoptics, etc.)
Figure 1 1-1. Airway diag nostic algorithm. LMA, laryngeal mask airways; RSI, rapid-sequence intubation.
ridge meant to sweep the tongue to the side during insertion
to improve visualization of the vocal cords. The Miller blade
is straight in appearance and meant to directly lift the
Figure 1 1-2. Proper method of BVM ventilation.
epiglottis away from the vocal cords. It is of particular benefit in patients with very anterior airways and those with a
large "floppy" epiglottis. A size 3 or 4 Macintosh blade is
appropriate for most adult ED patients (Figure 1 1-3).
Certain clinical scenarios warrant unique modifications to standard RSI to attenuate the adverse physiologic
responses to endotracheal intubation. Pretreat head injury
patients with lidocaine (1.5 mg/kg) and a "defasciculating"
dose of a nondepolarizing neuromuscular blocker ( eg,
pancuronium 0.01 mg/kg) to limit the potential spike in
ICP that may accompany ETT placement. Pretreat most
pediatric patients with an anticholinergic agent ( eg, atro
pine 0.02 mg/kg) to prevent reflex bradycardia. Pretreat
patients in whom rapid elevations in either blood pressure
or heart rate would be catastrophic (eg, aortic dissection)
with an opioid analgesic ( eg, fentanyl 3 meg/kg) to limit
excessive catecholamine surges. Of note, the clinical utility
of many of these pretreatment regimens has recently come
under considerable debate.
Outside of the pretreatment agents listed previously,
the remaining RSI medications can be divided into either
CHAPTER 11
Figure 1 1-3. Equi pment needed for orotracheal
intubation in an adu lt. From left to right, laryngoscope
handle attached to Macintosh 3 blade, Maci ntosh
4 blade, Miller 4 blade, end-tidal C02 detector,
1 0-ml syringe, and endotracheal tube with stylet.
induction agents or paralyzing agents. Induction agents are
designed to elicit extremely rapid sedation to facilitate ETT
placement. A variety of medications are available, including etomidate (0.3 mg/kg), propofol (1 mg/kg), ketamine
(2-3 mg/kg), and midazolam (0.05-0. 1 mg/kg). Of these,
etomidate is used most frequently in the ED because of its
rapid onset and offset and relative hemodynamic neutrality. Avoid the use of benzodiazepines and propofol in
hypotensive patients and ketamine in patients with paten
tial traumatic brain injury.
Paralytic agents can be divided into depolarizing and
nondepolarizing categories. Succinylcholine ( 1.5 mg/kg) is
the lone agent in the depolarizing class and the most commonly used paralytic for RSI because of its rapid onset and
short duration of activity. Most patients achieve r elaxation
within 1 minute, complete paralysis by the 2- to 3-minute
mark, and a return of motor function within 10 minutes.
Avoid succinylcholine in patients with known hyperkale
mia and those with pathologically denervated tissues (eg,
spinal cord injuries, burns) as it can precipitate life-threatening ventricular dysrhythmias. Given the longer duration
of paralysis for most nondepolarizing agents (eg, atracurium), their use is generally avoided in RSI.
Certain patients predicted to have difficult airways may
benefit from intubation via the use of lower than normal
doses of induction agents without concurrent paralytics.
Also known as the "awake look;' this limits the all too real
potential for creating the scenario of a paralyzed and,
therefore, not breathing patient who cannot be intubated.
Finally, apneic patients or those in cardiac arrest are not
Anterior
Vocal cords
.6. Figure 1 1-4. Laryngoscopic view. (Reproduced with
permission from Kempe CH, Si lver HK, O'Brien 0,
(editors): Current Pediatric Diagnosis Er Treatment. 4th ed.
lange, 1 976.)
candidates for RSI. Their condition does not allow time for
either preoxygenation or pretreatment, and being unconscious, they do not require RSI medications to facilitate
ETT placement. Temporize these patients with BVM venti
lation pending their emergent intubation.
To visualize the vocal cords, hold the laryngoscope in
the left hand and carefully insert the blade into the oropharynx directed downward along the tongue and into the
throat. Gentle upward traction should lift the epiglottis
from tl1e larynx and reveal the vocal cords (Figure 1 1-4).
Concurrent external laryngeal manipulation may shift the
patient's vocal cords into better view. Keep in mind that
pediatric airways are typically more anterior than those of
adults and that their relatively large tongues and floppy
epiglottis often necessitate the use of a Miller blade.
Insert the ETT and maintain visualization until the balloon has clearly passed the vocal cords. Advance the ETT
until the depth (at the teeth) is at 3 times the diameter of the
tube. Keep in mind this is only an estimate, and all patients
require a postprocedural CXR to document the depth of
ETT placement. Proper insertion can be inlmediately con firnled at the bedside by auscultating for Synlffietric bilateral
breath sounds and via the use of color-change capnography.
Gentle downward pressure applied to the cricoid cartilage (Sellick's maneuver) at the onset of induction and
paralysis has been historically advocated to limit the potential for aspiration. A growing body of literature has begun to
question the utility of this maneuver as it not only fails to
prevent aspiration but can limit adequate visualization of
the vocal cords and impair successful insertion of the ETT. If
cricoid pressure is applied, release inlmediately if the patient
begins to vomit to prevent secondary esophageal rupture.
� Difficult Airway Adjuncts
Multiple devices have been designed to assist with the
management of difficult airways. Laryngeal mask airways
AIRWAY MANAGEMENT
Figure 1 1-5. Schematic demonstrati ng use
of bougie.
(LMA) conform to the natural curvature of the oropharynx and are designed for blind insertion into the supraglottic region. Proper insertion creates an airtight seal over
the larynx, allowing for mechanical ventilation. LMA
insertion does not prevent aspiration, though, and is not
considered a definitive airway.
Introducer bougies are very useful in patients whose
vocal cords cannot be adequately visualized. They are
essentially long flexible rubber sty lets with a distal curve at
their tip, which, when blindly inserted along the inferior
margin of the epiglottis, will naturally angle upward into
the larynx and through the vocal cords. Successful endotracheal placement can be detected as the tip of the bougie
skips along the tracheal rings. The ETT is then inserted
blindly over the bougie and into the airway (Figure 1 1-5).
Cricothyrotomy is performed by making a percutane
ous incision in the cricothyroid membrane through which
a tracheostomy or small ETT can be placed (Figure 1 1-6).
This can be a life-saving intervention in the crashing
patient when less invasive techniques to secure the airway
have failed. Common indications include massive facial
trauma and angioedema. Cricothyrotomy is contraindi
cated in children <8 years of age and should be replaced
with needle cricothyrotomy.
Additional difficult airway adjuncts include blind nasatracheal intubation, lighted stylets, Combitubes, fiberoptic
intubation, retrograde wire-guided tracheal intubation,
and percutaneous translaryngeal ventilation.
DISPOSITION
Admit all patients who require airway management to an
intensive care unit setting.
Figure 1 1-6. Cricothyrotomy. A. An 11 blade
scalpel is used to cut the cricothyroid membrane. B. A
skin hook opens the incision and lifts the thyroid
carti lage su periorly so that the tracheostomy tube or
ETT can be inserted into the ai rway. (Reprinted with
permission from Bai l itz J, Bokhari F, Scaletta TA, et al.
Emergent Management of Trauma. 3rd ed. New York:
McGraw-Hill Education, 201 1 .)
SUGGESTED READINGS
Hedayati T, Ross C, Nasr N. Airway procedures. Rapid sequence
intubation. In: Simon RR, Ross CR, Bowman SH, Wakim PE.
Cook County Manual of Emergency Procedures. 1 st ed.
Philadelphia, PA: Lippincott Williams & Wilkins, 201 2, pp.
14-2 1.
Roman AM. Noninvasive airway management. In: Tintinalli JE,
Stapczynski JS, Ma OJ, Clince DM, Cydulka, RK, Meckler GD.
Tintinalli's Emergency Medicine: A Comprehensive Study Guide.
7th ed. New York, NY: McGraw-Hill, 20 11, pp. 183-190.
Vissers RJ, Danzl DF. Tracheal intubation and mechanical venti
lation. In: Tintinalli JE, Stapczynski JS, Ma OJ, Clince DM,
Cydulka, RK, Meckler GD. Tintinalli's Emergency Medicine: A
Comprehensive Study Guide. 7th ed. New York, NY: McGrawHill, 20 l l, pp. l 98-2 15.
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