Aminoglycosides are poorly absorbed from the gut and must therefore be delivered via parenteral routes.
A. True B. False
Aminoglycosides are most effective against which kind of microorganism?
Aerobic gram-negative bacteria
Anaerobic gram-negative bacteria
Aerobic gram-positive bacteria
Anaerobic gram-positive bacteria
Ototoxicity is more likely if aminoglycosides are administered with which of the following drug classes?
Loop diuretics
Metformin
Vancomycin
Cephalosporins
Which of the following statements about aminoglycosides is false?
They have short half-lives
They are bactericidal
They exacerbate weakness in myasthenia gravis patients
None of the Above
Which of the following beta-blockers also has additional alpha-blocking activity?
Nadolol
Pindolol
Labetalol
Esmolol
Which of these beta-blockers is a Class III antiarrhythmic agent?
Metoprolol
Esmolol
Sotalol
Bucindolol
Which of the following NSAIDs is a selective COX-2 inhibitor?
Indomethacin
Meloxicam
Etoricoxib
Mefenamic acid
Pernicious anemia results from a deficiency of which of these vitamins?
Vitamin C
Vitamin D
Vitamin B9
Vitamin B12
N-acetyl-p-benzoquinone imine levels rise in response to what state of drug toxicity?
Codeine
Acetazolamide
Acetaminophen
Diazepam
All these antihypertensive drugs are safe in pregnancy, except which?
Labetalol
Ramipril
Nifedipine
Methyldopa
Mesna is used to reduce the risk of hemorrhagic cystitis from which drug?
Heparin
Warfarin
Busulfan
Cyclophosphamide
Pyridoxine is an effective antidote for which of the following drugs?
Methotrexate
Anticholinergics
Isoniazid
Benzodiazepines
According to the Vaughan-Williams classification of antiarrhythmic drugs, which class works as potassium-channel blockers?
Class I
Class II
Class III
Class IV
Which of these antiviral drugs works by targeting NS5A?
Sofosbuvir
Paritaprevir
Ledipasvir
Dasabuvir
Which of these drugs should be avoided 48-hours before/after use of IV contrast media?
Phenytoin
Metformin
Voriconazole
Pyridostigmine
Which of these drug combinations is most effective at treating fulminant C. difficile infection?
Clarithromycin / doxycycline
Linezolid / metronidazole
Doxycycline / benzylpenicillin
Vancomycin / metronidazole
Which of these antifungal drugs works by inhibiting the enzyme, squalene epoxidase?
Amphotericin B
Caspofungin
Terbinafine
Griseofulvin
Terbutaline, magnesium sulfate, nifedipine, and indomethacin are all examples of which of these kinds of drug?
Beta-2 agonist
Tocolytic
NSAID
Eugeroic
Which of these antidotes is used to reverse opioid toxicity?
Octreotide
N-acetylcysteine
Naloxone
Flumazenil
Which drug works as a competitive reversible inhibitor of DPP-4, reducing enzymatic inactivation of the incretin hormones, GLP-1 and GIP?
Metformin
Pioglitazone
Nateglinide
Sitagliptin
Carbonic anhydrase inhibitors work by acting at which part of the nephron?
Proximal tubule
Loop of Henle
Distal tubule
Collecting duct
Which of the following drugs works by inhibiting the enzyme catechol-O-methyltransferase?
Entacapone
Rasagiline
Orphenadrine
Tetrabenazine
Which of the following drugs works by irreversibly inhibiting the H+/K+-ATPase pump in order to reduce acid secretion?
Aluminium hydroxide
Cimetidine
Omeprazole
Metoclopramide
Rhabdomylosis and myopathies are notable side effects of which drug class?
Alpha-blockers
5-alpha reductase inhibitors
Statins
Loop diuretics
“Red man syndrome” is an adverse effect of ________________.
Chloramphenicol
Phenytoin
Vancomycin
Lithium
All these drugs are known to cause hyperkalemia, except?
Trimethoprim
Lisinopril
Spironolactone
Albuterol
Which of these oral hypoglycemic drugs can cause weight loss?
Pioglitazone.
Exenatide
Gliclazide
Metformin
Which of these drugs causes Reye’s syndrome?
Acetaminophen
Ibuprofen
Aspirin
Tramadol
Tendon rupture / damage is a known side effect of which antimicrobial drug class?
Macrolides
Aminoglycosides
Oxazolidinediones
Fluoroquinolones
The enzyme system responsible for the metabolism of most drugs is
P-glycoprotein.
Alkaline Phosphatase
Creatine kinase.
Cytochrome P-450.
A patient was admitted to the hospital because of an acute episode of bronchial asthma. Theophylline was administered to the patient as an iv loading dose of 300 mg followed immediately by a constant rate iv infusion of 45 mg/hr. The theophylline steady-state concentration achieved is 15 mg/L ( k is 0.1 hr-1) calculate the volume of distribution
20 L
30 L
40 L
50 L
35-year-old woman is being started on lamotrigine for newly diagnosed epilepsy. She is otherwise healthy and is not taking any medications except for acetaminophen for an occasional headache. Which of the following will be most important to monitor as she starts lamotrigine?
Vision
Blood count
Rash
Heart rhythm
A new patient with Parkinson disease comes to the pharmacy with a prescription for pramipexole 0.25 mg at bedtime. Which of the following is the most common adverse effect of pramipexole?
Obsessive behavior
Livedo reticularis
Nausea
Thickening of heart valves
Which of the following is NOT action of digoxin?
positive chronotropic effect
positive inotropic effect
increase in renal blood flow
decrease in preload
Which molecule should not recommended in DM type 2 and heart failure stage c:
Glibenclamide
Pioglitazone
Metformin
b and c
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