BACKGROUND: Despite speckle tracking echocardiography (STE) has emerged as a sensitive technique for identifying myocardial
Abstract
BACKGROUND: Despite speckle tracking echocardiography (STE) has emerged as a sensitive technique for identifying myocardial dysfunction, there are little data available on the appropriate timing to perform STE in the serial assessment after anthracycline administration. Moreover, further uncertainty is increased in the context of STE application in diffuse large B-cell lymphoma (DLBCL) research, as most recommendations are inferred by studies conducted primarily in breast cancer.
OBJECTIVE: This study aimed to determine whether early measurement of strain parameters derived by STE could predict the development of cardiotoxicity.
METHODS: Sixty-five patients were included in the final analysis. The patients were evaluated at baseline, after the third cycle and sixth-eighth cycle, and during follow-up. Global longitudinal strain (GLS) was analyzed using STE, and left ventricular ejection fraction (LVEF) was calculated by real time 3D echocardiography (RT3DE).
RESULTS: There was a significant decrease in GLS after the third cycle of chemotherapy and remained decreased during subsequent follow-up, whereas LVEF decreased only at follow-up. A percentage reduction in GLS of 13.8% between baseline and the third cycle of chemotherapy was the best predictor of further LVEF reduction.
CONCLUSION: Earlier monitoring timing and more accurate assessment methods might be helpful in the prevention of irreversible heart failure.
PMID: 32112477 [PubMed - as supplied by publisher]
3 March 2020
12:05
Cancer & Heart (Cardio-Oncology, Cardiotoxicity, TEV)
Photo
Not included, change data exporting settings to download.
256×256, 6.0 KB
12:05
In reply to this message
pubmed: ctoall&ca or conall
Cardiac Magnetic Resonance T1 Mapping in Adolescent and Young Adult Survivors of Childhood Cancers.
Related Articles
Cardiac Magnetic Resonance T1 Mapping in Adolescent and Young Adult Survivors of Childhood Cancers.
Circ Cardiovasc Imaging. 2019 04;12(4):e008453
Authors: Tong X, Li VW, Liu AP, So EK, Chan Q, Ho KK, Yau JP, Cheuk DK, Cheung YF, Ng MY
PMID: 30929466 [PubMed - indexed for MEDLINE]
14:52
Cancer & Heart (Cardio-Oncology, Cardiotoxicity, TEV)
Photo
Not included, change data exporting settings to download.
256×256, 6.0 KB
14:52
In reply to this message
pubmed: caandvteortroorpul
Treatment of venous thromboembolism in acute leukemia: A systematic review.
//www.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles
Treatment of venous thromboembolism in acute leukemia: A systematic review.
Thromb Res. 2019 Jun;178:1-6
Authors: Ahrari A, Al-Ani F, Wang YP, Lazo-Langner A
Comments
Post a Comment
اكتب تعليق حول الموضوع