BACKGROUND: Limited biomarkers are used for predicting risk of venous thromboembolism (VTE) associated with cancer. Circulating

 

Abstract

BACKGROUND: Limited biomarkers are used for predicting risk of venous thromboembolism (VTE) associated with cancer. Circulating microparticles (MPs), especially tissue factor- positive microparticles (TF+MPs), play an important role in the development of cancer-associated VTE. This study investigated the predictive value of plasma MPs and TF+MPs for VTE in lung cancer.

METHODS: A case control study was performed using the Beijing Chao-Yang Hospital Lung Cancer Registry. Cases had VTE occurring 3 months before or after a diagnosis of lung cancer. Controls were patients with lung cancer without VTE matched for age, histology, and stage. The proportion of MPs and TF+MPs was evaluated by light-scatter-based flow cytometry.

RESULTS: Between January 2012 and December 2015, 30 case with VTE and 60 controls without VTE were included. The proportion of MPs and TF+MPs was significantly more elevated in patients with VTE than in those without VTE (P <0.05<0.001)<0.001)<0.001),

CONCLUSION: The elevated proportion of MPs and TF+MPs might help predict VTE associated with lung cancer.

PMID: 32031323 [PubMed - as supplied by publisher]

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