BACKGROUND: Our knowledge on the burden of symptomatic and asymptomatic venous thromboembolism (VTE) in

 

Abstract

BACKGROUND: Our knowledge on the burden of symptomatic 

and asymptomatic venous thromboembolism (VTE) in 

patients with cancer undergoing chemotherapy is 

limited. The aim of our study was to prospectively 

investigate the frequency of symptomatic VTE and 

asymptomatic deep vein thrombosis of the lower limbs 

among cancer patients undergoing chemotherapy.

METHODS: We studied 231 patients (164 men) with 

pancreatic (n=36), lung (n=136), ovarian (n=32) or 

prostate (n=27) cancer receiving first line (n=192, 

83.1%) or adjuvant chemotherapy, followed-up for 3-6 

months.

RESULTS: Some 17 patients were diagnosed with VTE, 

either asymptomatic detected on leg ultrasound (n=7) or 

symptomatic (n=10). The total frequency of VTE was 

10.3% (17/165 with follow-up). Pancreatic cancer had 

the highest frequency of VTE (4/25, 16%) followed by 

ovarian (3/26, 11.5%) and lung cancer (10/94, 10.6%). 

There was no statistically significant difference in 

VTE rates among cancer types (p=0.36). VTE occurred 

more frequently in the presence of metastases (13/85, 

15.3% vs. 4/80, 5.0%, for the remainder, p=0.03, OR 

3.4). In the subgroup of patients receiving first line 

treatment, VTE occurred more frequently in patients 

with metastases (13/84, 15.5% vs 2/53, 3.8%, for the 

remainder, p=0.033). In patients with pancreatic, lung 

or ovarian cancer receiving first line treatment, VTE 

occurred more frequently in patients with metastatic 

disease (19.1% vs. 4.0%, for the remainder, p=0.015).

CONCLUSIONS: VTE occurrence in this real-world patient 

cohort was high, reaching almost 20% in certain groups, 

like those with disseminated pancreatic, lung or 

ovarian cancer receiving first-line chemotherapy. 

Furthermore, VTE occurs mostly as a symptomatic event, 

being likely a result of the prothrombotic state of 

malignancy.

PMID: 32057213 [PubMed - as supplied by publisher]

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pubmed: caandvteortroorpul

Incidence of venous thromboembolism among patients 

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