Radiation therapy (RT) is an important component of cancer therapy, with >50% of cancer patients receiving

 

Abstract

Radiation therapy (RT) is an important component of 

cancer therapy, with >50% of cancer patients receiving 

RT. As the number of cancer survivors increases, the 

short- and long-term side effects of cancer therapy are 

of growing concern. Side effects of RT for thoracic 

tumors, notably cardiac and pulmonary toxicities, can 

cause morbidity and mortality in long-term cancer 

survivors. An understanding of the biological pathways 

and mechanisms involved in normal tissue toxicity from 

RT will improve future cancer treatments by reducing 

the risk of long-term side effects. Many of these 

mechanistic studies are performed in animal models of 

radiation exposure. In this area of research, the use 

of small animal image-guided RT with treatment planning 

systems that allow more accurate dose determination has 

the potential to revolutionize knowledge of clinically 

relevant tumor and normal tissue radiobiology. However, 

there are still a number of challenges to overcome to 

optimize such radiation delivery, including dose 

verification and calibration, determination of doses 

received by adjacent normal tissues that can affect 

outcomes, and motion management and identifying 

variation in doses due to animal heterogeneity. In 

addition, recent studies have begun to determine how 

animal strain and sex affect normal tissue radiation 

injuries. This review article discusses the known and 

potential benefits and caveats of newer technologies 

and methods used for small animal radiation delivery, 

as well as how the choice of animal models, including 

variables such as species, strain, and age, can alter 

the severity of cardiac radiation toxicities and impact 

their clinical relevance.

PMID: 32053873 [PubMed]

14:58

Cancer & Heart (Cardio-Oncology, Cardiotoxicity, TEV)

Photo

Not included, change data exporting settings to 

download.

256×256, 6.0 KB

14:58

In reply to this message

pubmed: caandvteortroorpul

Endobronchial ultrasound-guided radiofrequency ablation 

of lung tumors and mediastinal lymph nodes: a 

preclinical study in animal lung tumor and mediastinal 

adenopathy models.

Related Articles

Endobronchial ultrasound-guided radiofrequency ablation 

of lung tumors and mediastinal lymph nodes: a 

preclinical study in animal lung tumor and mediastinal 

adenopathy models.

Semin Thorac Cardiovasc Surg. 2020 Feb 10;:

Authors: Motooka Y, Fujino K, Gregor A, Bernards N, 

Chan H, Inage T, Ujiie H, Kato T, Kinoshita T, Ishiwata 

T, Suzuki M, Yasufuku K