is predicted to increase the exposure to paclitaxel.
Theoretical → Also see TABLE 15 p. 1378
▶ Clopidogrel is predicted to increase the concentration of
▶ Cobicistat is predicted to increase the exposure to cabazitaxel.
▶ Cobicistat is predicted to moderately increase the exposure to
docetaxel. Avoid or adjust dose.rStudy
is predicted to increase the exposure to paclitaxel.
is predicted to increase the exposure to cabazitaxel.
Theoretical → Also see TABLE 15 p. 1378
▶ Efavirenz is predicted to decrease the exposure to cabazitaxel.
▶ Eliglustat is predicted to increase the exposure to paclitaxel.
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to taxanes
(cabazitaxel, paclitaxel). Avoid.rStudy
▶ Fibrates (gemfibrozil) are predicted to increase the
concentration of paclitaxel.rAnecdotal
▶ HIV-protease inhibitors are predicted to increase the exposure
▶ HIV-protease inhibitors are predicted to moderately increase
the exposure to docetaxel. Avoid or adjust dose.rStudy
▶ HIV-protease inhibitors are predicted to increase the exposure
▶ Idelalisib is predicted to increase the exposure to cabazitaxel.
Avoid.rStudy → Also see TABLE 15 p. 1378
▶ Idelalisib is predicted to moderately increase the exposure to
docetaxel. Avoid or adjust dose.rStudy → Also see TABLE 15
is predicted to increase the exposure to paclitaxel.
Theoretical → Also see TABLE 15 p. 1378
is predicted to increase the exposure to cabazitaxel.
Theoretical → Also see TABLE 15 p. 1378
slightly increases the exposure to paclitaxel.r
▶ Leflunomide is predicted to increase the concentration of
paclitaxel.rAnecdotal → Also see TABLE 15 p. 1378
▶ Live vaccines are predicted to increase the risk of generalised
infection (possibly life-threatening) when given with taxanes
(docetaxel, paclitaxel). Public Health England advises avoid
(refer to Green Book).rTheoretical
▶ Macrolides (clarithromycin) are predicted to increase the
exposure to cabazitaxel. Avoid.rStudy
▶ Macrolides (clarithromycin) are predicted to moderately
docetaxel. Avoid or adjust dose.
▶ Macrolides (clarithromycin) are predicted to increase the
exposure to paclitaxel.rTheoretical
▶ Macrolides (erythromycin) are predicted to increase the
exposure to cabazitaxel.oTheoretical
▶ Mirabegron is predicted to increase the exposure to paclitaxel.
is predicted to decrease the exposure to docetaxel.
Theoretical → Also see TABLE 15 p. 1378
▶ Mitotane is predicted to decrease the exposure to taxanes
(cabazitaxel, paclitaxel). Avoid.rStudy → Also see TABLE 15
is predicted to increase the exposure to cabazitaxel.
slightly increases the exposure to docetaxel.
is predicted to increase the exposure to paclitaxel.
▶ Nevirapine is predicted to decrease the exposure to
is predicted to increase the exposure to cabazitaxel.
Theoretical → Also see TABLE 15 p. 1378
▶ Paritaprevir (with ritonavir and ombitasvir) is predicted to
increase the exposure to paclitaxel.oStudy
▶ Pibrentasvir (with glecaprevir) is predicted to increase the
▶ Pitolisant is predicted to decrease the exposure to docetaxel.
▶ Pitolisant is predicted to decrease the exposure to paclitaxel.
is predicted to decrease the exposure to docetaxel.
▶ Rifampicin is predicted to decrease the exposure to taxanes
(cabazitaxel, paclitaxel). Avoid.rStudy
▶ St John’s Wort is predicted to decrease the exposure to
▶ Teriflunomide is predicted to increase the concentration of
is predicted to increase the exposure to paclitaxel.
▶ Tedizolid is predicted to increase the exposure to imatinib.
▶ Tedizolid is predicted to increase the exposure to lapatinib.
▶ Tedizolid is predicted to increase the exposure to
methotrexate. Avoid.oTheoretical
▶ Tedizolid is predicted to increase the exposure to statins
(atorvastatin, fluvastatin, rosuvastatin). Avoid.oStudy
▶ Tedizolid is predicted to increase the exposure to sulfasalazine.
▶ Tedizolid is predicted to increase the exposure to topotecan.
▶ Tegafur potentially increases the concentration of
antiepileptics (fosphenytoin, phenytoin). Monitor concentration
increases the anticoagulant effect of coumarins.
▶ Folates are predicted to increase the risk of toxicity when
given with tegafur.rTheoretical
▶ H2 receptor antagonists (cimetidine) are predicted to increase
the risk of toxicity when given with tegafur.rTheoretical
▶ Live vaccines are predicted to increase the risk of generalised
infection (possibly life-threatening) when given with tegafur.
Public Health England advises avoid (refer to Green Book).
▶ Methotrexate is predicted to increase the risk of toxicity when
given with tegafur.rTheoretical
GENERAL INFORMATION If other nephrotoxic or neurotoxic
drugs are given, monitor renal and auditory function on
Telavancin → see TABLE 2 p. 1375 (nephrotoxicity), TABLE 19 p. 1379
(ototoxicity), TABLE 9 p. 1377 (QT-interval prolongation)
▶ Interferons (interferon alfa) are predicted to increase the risk of
peripheral neuropathy when given with
▶ Interferons (peginterferon alfa) increase the risk of peripheral
neuropathy when given with telbivudine. Avoid.rStudy
Telmisartan → see angiotensin-II receptor antagonists
▶ Telotristat ethyl is predicted to decrease the exposure to
. Avoid or adjust doravirine dose, p. 644.r
decreases the exposure to midazolam.
▶ Octreotide (short-acting) decreases the exposure to telotristat
ethyl. Telotristat ethyl should be taken at least 30 minutes
Temazepam → see TABLE 11 p. 1377 (CNS depressant effects)
Temozolomide → see alkylating agents
Temsirolimus → see TABLE 15 p. 1378 (myelosuppression)
▶ Antiarrhythmics (dronedarone) are predicted to increase the
concentration of temsirolimus.oTheoretical
▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone) are predicted to decrease the
concentration of temsirolimus. Avoid.rStudy
▶ Antifungals, azoles (fluconazole, isavuconazole, posaconazole)
are predicted to increase the concentration of
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the concentration of temsirolimus.
▶ Apalutamide is predicted to decrease the exposure to
temsirolimus. Avoid or monitor.oStudy
▶ Aprepitant is predicted to increase the concentration of
▶ Bosentan is predicted to decrease the concentration of
temsirolimus. Avoid.rTheoretical
▶ Calcium channel blockers (diltiazem, verapamil) are predicted to
temsirolimus.o ▶ Cobicistat is predicted to increase the concentration of
temsirolimus. Avoid.rTheoretical
▶ Crizotinib is predicted to increase the concentration of
temsirolimus.oTheoretical → Also see TABLE 15 p. 1378
▶ Efavirenz is predicted to decrease the concentration of
temsirolimus. Avoid.rTheoretical
▶ Enzalutamide is predicted to decrease the concentration of
▶ Grapefruit juice is predicted to increase the concentration of
temsirolimus. Use with caution or avoid.oTheoretical
▶ HIV-protease inhibitors are predicted to increase the
concentration of temsirolimus. Avoid.rTheoretical
▶ Idelalisib is predicted to increase the concentration of
temsirolimus. Avoid.rTheoretical → Also see TABLE 15 p. 1378
▶ Imatinib is predicted to increase the concentration of
temsirolimus.oTheoretical → Also see TABLE 15 p. 1378
▶ Live vaccines are predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
temsirolimus. Public Health England advises avoid (refer to
▶ Lumacaftor is predicted to decrease the exposure to
temsirolimus. Avoid.rTheoretical
▶ Macrolides (clarithromycin) are predicted to increase the
concentration of temsirolimus. Avoid.rTheoretical
▶ Macrolides (erythromycin) are predicted to increase the
concentration of temsirolimus.oTheoretical
▶ Mitotane is predicted to decrease the concentration of
temsirolimus. Avoid.rStudy → Also see TABLE 15 p. 1378
▶ Netupitant is predicted to increase the concentration of
▶ Nevirapine is predicted to decrease the concentration of
temsirolimus. Avoid.rTheoretical
▶ Nilotinib is predicted to increase the concentration of
temsirolimus.oTheoretical → Also see TABLE 15 p. 1378
▶ Pitolisant is predicted to decrease the exposure to
temsirolimus. Avoid.rTheoretical
▶ Rifampicin is predicted to decrease the concentration of
▶ St John’s Wort is predicted to decrease the concentration of
temsirolimus. Avoid.rTheoretical
Tenecteplase → see TABLE 3 p. 1375 (anticoagulant effects)
▶ Antiepileptics (carbamazepine, fosphenytoin, oxcarbazepine,
phenobarbital, phenytoin, primidone) are predicted to decrease
tenofovir alafenamide. Avoid.o ▶ Ciclosporin is predicted to increase the exposure to tenofovir
▶ Eltrombopag is predicted to increase the exposure to tenofovir
▶ HIV-protease inhibitors (atazanavir, darunavir, lopinavir) increase
tenofovir alafenamide. Avoid or adjust dose.
▶ HIV-protease inhibitors (tipranavir) are predicted to decrease the
exposure to tenofovir alafenamide. Avoid.oTheoretical
▶ Leflunomide is predicted to increase the exposure to tenofovir
▶ Rifabutin is predicted to decrease the exposure to tenofovir
alafenamide. Avoid.oTheoretical
▶ Rifampicin is predicted to decrease the exposure to tenofovir
alafenamide. Avoid.oTheoretical
▶ St John’s Wort is predicted to decrease the exposure to
tenofovir alafenamide. Avoid.oTheoretical
▶ Teriflunomide is predicted to increase the exposure to
tenofovir alafenamide.oTheoretical
Tenofovir disoproxil → see TABLE 2 p. 1375 (nephrotoxicity)
▶ Ciclosporin is predicted to increase the exposure to tenofovir
disoproxil.oTheoretical → Also see TABLE 2 p. 1375
▶ Tenofovir disoproxil increases the risk of toxicity when given
▶ Eltrombopag is predicted to increase the exposure to tenofovir
▶ HIV-protease inhibitors (atazanavir, darunavir, lopinavir) are
predicted to increase the risk of renal impairment when given
with tenofovir disoproxil.rAnecdotal
▶ Ledipasvir (with sofosbuvir) slightly increases the exposure to
▶ Leflunomide is predicted to increase the exposure to tenofovir
▶ Teriflunomide is predicted to increase the exposure to
tenofovir disoproxil.oTheoretical
▶ Velpatasvir is predicted to increase the exposure to tenofovir
▶ Voxilaprevir (with sofosbuvir and velpatasvir) potentially
increases the concentration of
Terazosin → see alpha blockers
ROUTE-SPECIFIC INFORMATION Since systemic absorption can
follow topical application, the possibility of interactions
▶ Terbinafine is predicted to increase the exposure to
anticholinesterases, centrally acting (galantamine). Monitor and
▶ Terbinafine is predicted to moderately increase the exposure
to aripiprazole. Adjust aripiprazole dose, p. 395.oStudy
▶ Terbinafine is predicted to markedly increase the exposure to
atomoxetine. Adjust dose.rStudy
▶ Terbinafine is predicted to increase the exposure to beta
blockers, selective (metoprolol, nebivolol).oStudy
BNF 78 Tegafur —Terbinafine 1541
▶ Terbinafine is predicted to slightly increase the exposure to
▶ Terbinafine is predicted to increase the exposure to eliglustat.
Avoid or adjust dose—consult product literature.rStudy
is predicted to increase the exposure to mexiletine.
▶ Terbinafine is predicted to decrease the efficacy of opioids
▶ Terbinafine is predicted to decrease the efficacy of opioids
▶ Terbinafine is predicted to moderately increase the exposure
to pitolisant. Use with caution and adjust dose.oStudy
decreases the exposure to terbinafine. Adjust dose.
▶ Terbinafine is predicted to increase the exposure to
risperidone. Adjust dose.oStudy
▶ Terbinafine is predicted to increase the exposure to SSRIs
(citalopram, dapoxetine, escitalopram, fluvoxamine, sertraline)
▶ Terbinafine is predicted to increase the exposure to SSRIs
(fluoxetine). Adjust dose.oTheoretical
▶ Terbinafine moderately increases the exposure to SSRIs
▶ Terbinafine is predicted to decrease the efficacy of tamoxifen.
▶ Terbinafine is predicted to increase the exposure to tricyclic
. Monitor for toxicity and adjust dose.r
▶ Terbinafine is predicted to increase the exposure to
vortioxetine. Monitor and adjust dose.oStudy
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