rifampicin. Avoid.

Study

▶ Rifampicin is predicted to decrease the exposure to antifungals,

azoles (posaconazole). Avoid.oAnecdotal

▶ Rifampicin very markedly decreases the exposure to

antifungals, azoles (voriconazole). Avoid.oStudy

▶ Rifampicin is predicted to decrease the exposure to

antihistamines, non-sedating (bilastine).oTheoretical

▶ Rifampicin increases the clearance of antihistamines, nonsedating (fexofenadine).oStudy

▶ Rifampicin is predicted to decrease the exposure to

antimalarials

Study

(artemether) (with lumefantrine). Avoid.r

▶ Rifampicin moderately decreases the exposure to antimalarials

(atovaquone) and antimalarials (atovaquone) slightly increase

the exposure to rifampicin. Avoid.oStudy

▶ Rifampicin moderately decreases the exposure to antimalarials

(mefloquine).rStudy

▶ Rifampicin is predicted to decrease the concentration of

antimalarials (piperaquine). Avoid.oTheoretical

▶ Rifampicin

r

decreases the exposure to antimalarials (quinine).

Study

▶ Rifampicin is predicted to moderately decrease the exposure

to apixaban. Use with caution or avoid.rStudy

▶ Rifampicin moderately decreases the exposure to apremilast.

Avoid.rStudy

▶ Rifampicin is predicted to markedly decrease the exposure to

aprepitant. Avoid.oStudy

▶ Rifampicin is predicted to moderately decrease the exposure

to aripiprazole. Adjust aripiprazole dose, p. 395.oStudy

▶ Rifampicin decreases the exposure to ataluren.oStudy

▶ Rifampicin is predicted to decrease the exposure to axitinib.

Avoid or adjust dose.oStudy

▶ Rifampicin is predicted to decrease the exposure to

bazedoxifene.oTheoretical

▶ Rifampicin

r

decreases the exposure to bedaquiline. Avoid.

Study

▶ Rifampicin moderately decreases the exposure to beta blockers,

non-selective (carvedilol).oStudy

▶ Rifampicin decreases the exposure to beta blockers, nonselective (propranolol). Monitor and adjust dose.oStudy

▶ Rifampicin slightly decreases the exposure to beta blockers,

selective (bisoprolol, metoprolol).nStudy

▶ Rifampicin moderately decreases the exposure to beta blockers,

selective (celiprolol).oStudy

▶ Rifampicin is predicted to decrease the exposure to bictegravir.

Avoid.oStudy

▶ Rifampicin slightly decreases the exposure to bortezomib.

Avoid.rStudy

▶ Rifampicin

Study

affects the exposure to bosentan. Avoid.r

▶ Rifampicin is predicted to very markedly decrease the

exposure to bosutinib. Avoid.rStudy

▶ Rifampicin is predicted to decrease the exposure to brigatinib.

Avoid.rStudy

▶ Rifampicin

o

is predicted to decrease the exposure to bupropion.

Study

▶ Rifampicin is predicted to decrease the exposure to buspirone.

Use with caution and adjust dose.rStudy

▶ Rifampicin moderately decreases the exposure to cabozantinib.

Avoid.oStudy

▶ Rifampicin is predicted to moderately increase the clearance of

caffeine citrate. Monitor and adjust dose.oStudy

▶ Rifampicin is predicted to decrease the exposure to calcium

channel blockers (amlodipine, felodipine, lacidipine,

lercanidipine, nicardipine, nimodipine). Monitor and adjust

dose.oStudy

▶ Rifampicin greatly decreases the exposure to calcium channel

blockers (diltiazem, verapamil).rStudy

▶ Rifampicin moderately decreases the exposure to calcium

channel blockers (nifedipine). Avoid.rStudy

▶ Rifampicin moderately decreases the exposure to canagliflozin.

Adjust canagliflozin dose, p. 702.oStudy

▶ Rifampicin is predicted to decrease the exposure to cannabis

extract. Avoid.rTheoretical

▶ Rifampicin is predicted to decrease the exposure to

cariprazine. Avoid.rTheoretical

▶ Rifampicin decreases the concentration of caspofungin. Adjust

caspofungin dose, p. 592.oStudy

▶ Rifampicin is predicted to decrease the exposure to ceritinib.

Avoid.rStudy

▶ Rifampicin

o

decreases the concentration of chloramphenicol.

Study

▶ Rifampicin is predicted to decrease the exposure to

chlordiazepoxide.oTheoretical

▶ Rifampicin

Study

decreases the concentration of ciclosporin.r

▶ Rifampicin

o

is predicted to alter the effects of cilostazol.

Theoretical

▶ Rifampicin is predicted to decrease the exposure to cinacalcet.

Monitor and adjust dose.oStudy

▶ Rifampicin decreases the exposure to clomethiazole. Monitor

and adjust dose.oStudy

▶ Rifampicin

Anecdotal

decreases the exposure to clozapine.r

▶ Rifampicin is predicted to decrease the exposure to cobicistat.

Avoid.rTheoretical

▶ Rifampicin is predicted to decrease the exposure to

cobimetinib. Avoid.rTheoretical

▶ Rifampicin is predicted to decrease the efficacy of combined

hormonal contraceptives. For FSRH guidance, see

Contraceptives, interactions p. 794.rStudy

▶ Rifampicin is predicted to decrease the exposure to

corticosteroids (budesonide, deflazacort, dexamethasone,

fludrocortisone, hydrocortisone, methylprednisolone,

prednisolone, triamcinolone)

o

. Monitor and adjust dose.

Study

▶ Rifampicin is predicted to decrease the exposure to

corticosteroids (fluticasone).qTheoretical

▶ Rifampicin

r

decreases the anticoagulant effect of coumarins.

Study

▶ Rifampicin is predicted to markedly decrease the exposure to

crizotinib. Avoid.rStudy

▶ Rifampicin is predicted to decrease the exposure to dabigatran.

Avoid.rStudy

▶ Rifampicin is predicted to decrease the exposure to dabrafenib.

Avoid.oTheoretical

▶ Rifampicin decreases the exposure to dapsone.oStudy

▶ Rifampicin is predicted to decrease the exposure to

darifenacin.oTheoretical

BNF 78 Rifampicin — Rifampicin 1523

Interactions | Appendix 1

A1

Rifampicin (continued)

▶ Rifampicin is predicted to decrease the exposure to dasabuvir.

Avoid.rTheoretical

▶ Rifampicin is predicted to markedly decrease the exposure to

dasatinib. Avoid.rStudy

▶ Rifampicin is predicted to slightly decrease the exposure to

delamanid. Avoid.oStudy

▶ Rifampicin is predicted to decrease the efficacy of desogestrel.

For FSRH guidance, see

r

Contraceptives, interactions p. 794.

Theoretical

▶ Rifampicin moderately decreases the exposure to diazepam.

Avoid.oStudy

▶ Rifampicin

Study

decreases the concentration of digoxin.o ▶ Rifampicin decreases the exposure to dolutegravir. Adjust

dose.rStudy

▶ Rifampicin is predicted to decrease the exposure to doravirine.

Avoid.rStudy

▶ Rifampicin

o

is predicted to decrease the exposure to duloxetine.

Theoretical

▶ Rifampicin

o

is predicted to decrease the exposure to edoxaban.

Study

▶ Rifampicin slightly decreases the exposure to efavirenz. Adjust

dose.rStudy

▶ Rifampicin is predicted to decrease the exposure to elbasvir.

Avoid.rStudy

▶ Rifampicin is predicted to decrease the exposure to eliglustat.

Avoid.rStudy

▶ Rifampicin is predicted to decrease the exposure to

eltrombopag and eltrombopag is predicted to increase the

concentration of rifampicin.oTheoretical

▶ Rifampicin is predicted to decrease the concentration of

elvitegravir. Avoid.rTheoretical

▶ Rifampicin is predicted to decrease the exposure to

encorafenib.rTheoretical

▶ Rifampicin

o

is predicted to decrease the effects of ergotamine.

Theoretical

▶ Rifampicin is predicted to decrease the exposure to erlotinib.

Avoid or adjust erlotinib dose, p. 979.rStudy

▶ Rifampicin is predicted to decrease the exposure to

esketamine. Adjust dose.oTheoretical

▶ Rifampicin is predicted to decrease the efficacy of etonogestrel.

For FSRH guidance, see

r

Contraceptives, interactions p. 794.

Theoretical

▶ Rifampicin is predicted to decrease the exposure to etravirine.

Avoid.rTheoretical

▶ Rifampicin is predicted to decrease the concentration of

everolimus. Avoid or adjust dose.rStudy

▶ Rifampicin

o

moderately decreases the exposure to exemestane.

Study

▶ Rifampicin is predicted to decrease the exposure to

fesoterodine. Avoid.oStudy

▶ Rifampicin

o

is predicted to decrease the exposure to fingolimod.

Study

▶ Rifampicin is predicted to decrease the exposure to

fosaprepitant. Avoid.oTheoretical

▶ Rifampicin is predicted to decrease the exposure to gefitinib.

Avoid.rStudy

▶ Rifampicin markedly affects the exposure to glecaprevir.

Avoid.rStudy

▶ Rifampicin is predicted to decrease the exposure to

grazoprevir. Avoid.rStudy

▶ Rifampicin is predicted to decrease the concentration of

guanfacine. Adjust guanfacine dose, p. 352.oStudy

▶ Rifampicin decreases the concentration of haloperidol. Adjust

dose.oStudy

▶ Rifampicin is predicted to moderately to markedly decrease

the exposure to HIV-protease inhibitors (atazanavir, darunavir,

fosamprenavir, lopinavir, saquinavir). Avoid.rStudy

▶ Rifampicin slightly decreases the exposure to HIV-protease

inhibitors (ritonavir).rStudy

▶ Rifampicin is predicted to decrease the exposure to HIVprotease inhibitors (tipranavir). Avoid.rStudy

▶ Rifampicin is predicted to decrease the effects of hormone

replacement therapy.oAnecdotal

▶ Rifampicin is predicted to decrease the exposure to ibrutinib.

Avoid or adjust ibrutinib dose, p. 983.rStudy

▶ Rifampicin is predicted to decrease the exposure to idelalisib.

Avoid.rStudy

▶ Rifampicin is predicted to decrease the exposure to imatinib.

Avoid.oStudy

▶ Rifampicin is predicted to decrease the exposure to irinotecan.

Avoid.rStudy

▶ Rifampicin is predicted to decrease the exposure to iron

chelators

o

(deferasirox). Monitor serum ferritin and adjust dose.

Study

▶ Rifampicin is predicted to decrease the exposure to ivabradine.

Adjust dose.oTheoretical

▶ Rifampicin is predicted to moderately to markedly decrease

the exposure to ivacaftor. Avoid.rStudy

▶ Rifampicin is predicted to decrease the exposure to ixazomib.

Avoid.rStudy

▶ Rifampicin is predicted to decrease the exposure to lapatinib.

Avoid.rStudy

▶ Rifampicin is predicted to decrease the exposure to ledipasvir.

Avoid.rStudy

▶ Leflunomide is predicted to increase the exposure to

rifampicin.oTheoretical

▶ Rifampicin is predicted to affect the concentration of

letermovir.rTheoretical

▶ Rifampicin is predicted to decrease the efficacy of

levonorgestrel. For FSRH guidance, see Contraceptives,

interactions p. 794.rTheoretical

▶ Rifampicin

o

is predicted to decrease the exposure to linagliptin.

Study

▶ Rifampicin

o

slightly decreases the exposure to linezolid.

Study

▶ Rifampicin is predicted to decrease the exposure to lomitapide.

Monitor and adjust dose.oTheoretical

▶ Rifampicin

Study

increases the clearance of lorazepam.o ▶ Rifampicin is predicted to decrease the exposure to lurasidone.

Avoid.oStudy

▶ Rifampicin is predicted to decrease the exposure to

macitentan. Avoid.rStudy

▶ Rifampicin decreases the concentration of macrolides

(clarithromycin).rStudy

▶ Rifampicin is predicted to decrease the exposure to maraviroc.

Adjust dose.rStudy

▶ Rifampicin

o

is predicted to decrease the exposure to melatonin.

Theoretical

▶ Rifampicin is predicted to increase the clearance of mexiletine.

Monitor and adjust dose.oStudy

▶ Rifampicin is predicted to decrease the exposure to midazolam.

Monitor and adjust dose.oStudy

▶ Rifampicin is predicted to decrease the exposure to

midostaurin. Avoid.rStudy

▶ Rifampicin is predicted to decrease the exposure to

mirtazapine. Adjust dose.oStudy

▶ Rifampicin

o

is predicted to decrease the exposure to modafinil.

Theoretical

▶ Rifampicin decreases the effects of monoclonal antibodies

(brentuximab vedotin).rStudy

▶ Rifampicin is predicted to decrease the exposure to

montelukast.nStudy

▶ Rifampicin decreases the concentration of mycophenolate.

Monitor and adjust dose.rStudy

▶ Rifampicin is predicted to markedly decrease the exposure to

naloxegol. Avoid.oStudy

▶ Rifampicin is predicted to slightly decrease the exposure to

nateglinide.nStudy

▶ Rifampicin is predicted to decrease the exposure to netupitant.

Avoid.rStudy

▶ Rifampicin

r

decreases the concentration of nevirapine. Avoid.

Study

▶ Rifampicin is predicted to moderately decrease the exposure

to nilotinib. Avoid.rStudy

▶ Rifampicin

o

is predicted to decrease the exposure to nintedanib.

Study

1524 Rifampicin — Rifampicin BNF 78

Interactions | Appendix 1

A1

▶ Rifampicin is predicted to decrease the exposure to nitisinone.

Adjust dose.oTheoretical

▶ Rifampicin

Study

increases the clearance of nitrazepam.o ▶ Rifampicin is predicted to decrease the efficacy of

norethisterone. For FSRH guidance, see Contraceptives,

interactions p. 794.rAnecdotal

▶ Rifampicin moderately decreases the exposure to NSAIDs

(celecoxib, diclofenac, etoricoxib).oStudy

▶ Rifampicin is predicted to decrease the exposure to olanzapine.

Monitor and adjust dose.oStudy

▶ Rifampicin is predicted to decrease the exposure to olaparib.

Avoid.oTheoretical

▶ Rifampicin is predicted to decrease the exposure to ombitasvir.

Avoid.rTheoretical

▶ Rifampicin is predicted to decrease the exposure to

ondansetron.oStudy

▶ Rifampicin is predicted to decrease the exposure to opioids

(alfentanil, fentanyl).oStudy

▶ Rifampicin is predicted to decrease the exposure to opioids

(buprenorphine). Monitor and adjust dose.oTheoretical

▶ Rifampicin decreases the exposure to opioids (codeine,

morphine).oStudy

▶ Rifampicin decreases the exposure to opioids (methadone).

Monitor and adjust dose.rStudy

▶ Rifampicin is predicted to decrease the exposure to opioids

(oxycodone). Monitor and adjust dose.oStudy

▶ Rifampicin is predicted to moderately decrease the exposure

to osimertinib. Avoid.oStudy

▶ Rifampicin is predicted to moderately decrease the exposure

to ospemifene.oStudy

▶ Rifampicin is predicted to decrease the exposure to palbociclib.

Avoid.rStudy

▶ Rifampicin is predicted to decrease the exposure to

paliperidone. Monitor and adjust dose.rStudy

▶ Rifampicin is predicted to decrease the exposure to

panobinostat. Avoid.oTheoretical

▶ Rifampicin

Study

decreases the exposure to paracetamol.o ▶ Rifampicin is predicted to decrease the exposure to

paritaprevir

Study

(with ritonavir and ombitasvir). Avoid.r

▶ Rifampicin is predicted to decrease the exposure to pazopanib.

Avoid.rTheoretical

▶ Rifampicin is predicted to decrease the exposure to

phosphodiesterase type-5 inhibitors

r

(avanafil, tadalafil). Avoid.

Study

▶ Rifampicin is predicted to decrease the exposure to

phosphodiesterase type-5 inhibitors

o

(sildenafil, vardenafil).

Theoretical

▶ Rifampicin is predicted to moderately to markedly decrease

the exposure to pibrentasvir. Avoid.rStudy

▶ Rifampicin moderately decreases the exposure to pioglitazone.

Monitor and adjust dose.oStudy

▶ Rifampicin is predicted to decrease the exposure to

pirfenidone. Avoid.oTheoretical

▶ Rifampicin is predicted to moderately decrease the exposure

to pitolisant.oStudy

▶ Rifampicin is predicted to decrease the exposure to ponatinib.

Avoid.oTheoretical

▶ Rifampicin is predicted to markedly decrease the exposure to

praziquantel. Avoid.oStudy

▶ Rifampicin

o

is predicted to decrease the exposure to quetiapine.

Study

▶ Rifampicin slightly decreases the exposure to raltegravir.

Avoid or adjust dose

Study

—consult product literature.o ▶ Rifampicin is predicted to decrease the exposure to ranolazine.

Avoid.rStudy

▶ Rifampicin

o

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