▶ Rifampicin is predicted to decrease the exposure to antifungals,
azoles (posaconazole). Avoid.oAnecdotal
▶ Rifampicin very markedly decreases the exposure to
antifungals, azoles (voriconazole). Avoid.oStudy
▶ Rifampicin is predicted to decrease the exposure to
antihistamines, non-sedating (bilastine).oTheoretical
▶ Rifampicin increases the clearance of antihistamines, nonsedating (fexofenadine).oStudy
▶ Rifampicin is predicted to decrease the exposure to
(artemether) (with lumefantrine). Avoid.r
▶ Rifampicin moderately decreases the exposure to antimalarials
(atovaquone) and antimalarials (atovaquone) slightly increase
the exposure to rifampicin. Avoid.oStudy
▶ Rifampicin moderately decreases the exposure to antimalarials
▶ Rifampicin is predicted to decrease the concentration of
antimalarials (piperaquine). Avoid.oTheoretical
decreases the exposure to antimalarials (quinine).
▶ Rifampicin is predicted to moderately decrease the exposure
to apixaban. Use with caution or avoid.rStudy
▶ Rifampicin moderately decreases the exposure to apremilast.
▶ Rifampicin is predicted to markedly decrease the exposure to
▶ Rifampicin is predicted to moderately decrease the exposure
to aripiprazole. Adjust aripiprazole dose, p. 395.oStudy
▶ Rifampicin decreases the exposure to ataluren.oStudy
▶ Rifampicin is predicted to decrease the exposure to axitinib.
▶ Rifampicin is predicted to decrease the exposure to
decreases the exposure to bedaquiline. Avoid.
▶ Rifampicin moderately decreases the exposure to beta blockers,
non-selective (carvedilol).oStudy
▶ Rifampicin slightly decreases the exposure to beta blockers,
selective (bisoprolol, metoprolol).nStudy
▶ Rifampicin moderately decreases the exposure to beta blockers,
▶ Rifampicin is predicted to decrease the exposure to bictegravir.
▶ Rifampicin slightly decreases the exposure to bortezomib.
affects the exposure to bosentan. Avoid.r
▶ Rifampicin is predicted to very markedly decrease the
exposure to bosutinib. Avoid.rStudy
▶ Rifampicin is predicted to decrease the exposure to brigatinib.
is predicted to decrease the exposure to bupropion.
▶ Rifampicin is predicted to decrease the exposure to buspirone.
Use with caution and adjust dose.rStudy
▶ Rifampicin moderately decreases the exposure to cabozantinib.
▶ Rifampicin is predicted to moderately increase the clearance of
caffeine citrate. Monitor and adjust dose.oStudy
▶ Rifampicin is predicted to decrease the exposure to calcium
channel blockers (amlodipine, felodipine, lacidipine,
lercanidipine, nicardipine, nimodipine). Monitor and adjust
▶ Rifampicin greatly decreases the exposure to calcium channel
blockers (diltiazem, verapamil).rStudy
▶ Rifampicin moderately decreases the exposure to calcium
channel blockers (nifedipine). Avoid.rStudy
▶ Rifampicin moderately decreases the exposure to canagliflozin.
Adjust canagliflozin dose, p. 702.oStudy
▶ Rifampicin is predicted to decrease the exposure to cannabis
▶ Rifampicin is predicted to decrease the exposure to
cariprazine. Avoid.rTheoretical
▶ Rifampicin decreases the concentration of caspofungin. Adjust
caspofungin dose, p. 592.oStudy
▶ Rifampicin is predicted to decrease the exposure to ceritinib.
decreases the concentration of chloramphenicol.
▶ Rifampicin is predicted to decrease the exposure to
decreases the concentration of ciclosporin.r
is predicted to alter the effects of cilostazol.
▶ Rifampicin is predicted to decrease the exposure to cinacalcet.
Monitor and adjust dose.oStudy
▶ Rifampicin decreases the exposure to clomethiazole. Monitor
decreases the exposure to clozapine.r
▶ Rifampicin is predicted to decrease the exposure to cobicistat.
▶ Rifampicin is predicted to decrease the exposure to
cobimetinib. Avoid.rTheoretical
▶ Rifampicin is predicted to decrease the efficacy of combined
hormonal contraceptives. For FSRH guidance, see
Contraceptives, interactions p. 794.rStudy
▶ Rifampicin is predicted to decrease the exposure to
corticosteroids (budesonide, deflazacort, dexamethasone,
fludrocortisone, hydrocortisone, methylprednisolone,
▶ Rifampicin is predicted to decrease the exposure to
corticosteroids (fluticasone).qTheoretical
decreases the anticoagulant effect of coumarins.
▶ Rifampicin is predicted to markedly decrease the exposure to
▶ Rifampicin is predicted to decrease the exposure to dabigatran.
▶ Rifampicin is predicted to decrease the exposure to dabrafenib.
▶ Rifampicin decreases the exposure to dapsone.oStudy
▶ Rifampicin is predicted to decrease the exposure to
BNF 78 Rifampicin — Rifampicin 1523
▶ Rifampicin is predicted to decrease the exposure to dasabuvir.
▶ Rifampicin is predicted to markedly decrease the exposure to
▶ Rifampicin is predicted to slightly decrease the exposure to
▶ Rifampicin is predicted to decrease the efficacy of desogestrel.
Contraceptives, interactions p. 794.
▶ Rifampicin moderately decreases the exposure to diazepam.
decreases the concentration of digoxin.o ▶ Rifampicin decreases the exposure to dolutegravir. Adjust
▶ Rifampicin is predicted to decrease the exposure to doravirine.
is predicted to decrease the exposure to duloxetine.
is predicted to decrease the exposure to edoxaban.
▶ Rifampicin slightly decreases the exposure to efavirenz. Adjust
▶ Rifampicin is predicted to decrease the exposure to elbasvir.
▶ Rifampicin is predicted to decrease the exposure to eliglustat.
▶ Rifampicin is predicted to decrease the exposure to
eltrombopag and eltrombopag is predicted to increase the
concentration of rifampicin.oTheoretical
▶ Rifampicin is predicted to decrease the concentration of
elvitegravir. Avoid.rTheoretical
▶ Rifampicin is predicted to decrease the exposure to
is predicted to decrease the effects of ergotamine.
▶ Rifampicin is predicted to decrease the exposure to erlotinib.
Avoid or adjust erlotinib dose, p. 979.rStudy
▶ Rifampicin is predicted to decrease the exposure to
esketamine. Adjust dose.oTheoretical
▶ Rifampicin is predicted to decrease the efficacy of etonogestrel.
Contraceptives, interactions p. 794.
▶ Rifampicin is predicted to decrease the exposure to etravirine.
▶ Rifampicin is predicted to decrease the concentration of
everolimus. Avoid or adjust dose.rStudy
moderately decreases the exposure to exemestane.
▶ Rifampicin is predicted to decrease the exposure to
is predicted to decrease the exposure to fingolimod.
▶ Rifampicin is predicted to decrease the exposure to
fosaprepitant. Avoid.oTheoretical
▶ Rifampicin is predicted to decrease the exposure to gefitinib.
▶ Rifampicin markedly affects the exposure to glecaprevir.
▶ Rifampicin is predicted to decrease the exposure to
▶ Rifampicin is predicted to decrease the concentration of
guanfacine. Adjust guanfacine dose, p. 352.oStudy
▶ Rifampicin decreases the concentration of haloperidol. Adjust
▶ Rifampicin is predicted to moderately to markedly decrease
the exposure to HIV-protease inhibitors (atazanavir, darunavir,
fosamprenavir, lopinavir, saquinavir). Avoid.rStudy
▶ Rifampicin slightly decreases the exposure to HIV-protease
▶ Rifampicin is predicted to decrease the effects of hormone
replacement therapy.oAnecdotal
▶ Rifampicin is predicted to decrease the exposure to ibrutinib.
Avoid or adjust ibrutinib dose, p. 983.rStudy
▶ Rifampicin is predicted to decrease the exposure to idelalisib.
▶ Rifampicin is predicted to decrease the exposure to imatinib.
▶ Rifampicin is predicted to decrease the exposure to irinotecan.
▶ Rifampicin is predicted to decrease the exposure to iron
(deferasirox). Monitor serum ferritin and adjust dose.
▶ Rifampicin is predicted to decrease the exposure to ivabradine.
▶ Rifampicin is predicted to moderately to markedly decrease
the exposure to ivacaftor. Avoid.rStudy
▶ Rifampicin is predicted to decrease the exposure to ixazomib.
▶ Rifampicin is predicted to decrease the exposure to lapatinib.
▶ Rifampicin is predicted to decrease the exposure to ledipasvir.
▶ Leflunomide is predicted to increase the exposure to
▶ Rifampicin is predicted to affect the concentration of
▶ Rifampicin is predicted to decrease the efficacy of
levonorgestrel. For FSRH guidance, see Contraceptives,
interactions p. 794.rTheoretical
is predicted to decrease the exposure to linagliptin.
slightly decreases the exposure to linezolid.
▶ Rifampicin is predicted to decrease the exposure to lomitapide.
Monitor and adjust dose.oTheoretical
▶ Rifampicin is predicted to decrease the exposure to
▶ Rifampicin decreases the concentration of macrolides
▶ Rifampicin is predicted to decrease the exposure to maraviroc.
is predicted to decrease the exposure to melatonin.
▶ Rifampicin is predicted to increase the clearance of mexiletine.
Monitor and adjust dose.oStudy
▶ Rifampicin is predicted to decrease the exposure to midazolam.
Monitor and adjust dose.oStudy
▶ Rifampicin is predicted to decrease the exposure to
▶ Rifampicin is predicted to decrease the exposure to
mirtazapine. Adjust dose.oStudy
is predicted to decrease the exposure to modafinil.
▶ Rifampicin decreases the effects of monoclonal antibodies
▶ Rifampicin is predicted to decrease the exposure to
▶ Rifampicin decreases the concentration of mycophenolate.
Monitor and adjust dose.rStudy
▶ Rifampicin is predicted to markedly decrease the exposure to
▶ Rifampicin is predicted to slightly decrease the exposure to
▶ Rifampicin is predicted to decrease the exposure to netupitant.
decreases the concentration of nevirapine. Avoid.
▶ Rifampicin is predicted to moderately decrease the exposure
is predicted to decrease the exposure to nintedanib.
1524 Rifampicin — Rifampicin BNF 78
▶ Rifampicin is predicted to decrease the exposure to nitisinone.
increases the clearance of nitrazepam.o ▶ Rifampicin is predicted to decrease the efficacy of
norethisterone. For FSRH guidance, see Contraceptives,
interactions p. 794.rAnecdotal
▶ Rifampicin moderately decreases the exposure to NSAIDs
(celecoxib, diclofenac, etoricoxib).oStudy
▶ Rifampicin is predicted to decrease the exposure to olanzapine.
Monitor and adjust dose.oStudy
▶ Rifampicin is predicted to decrease the exposure to olaparib.
▶ Rifampicin is predicted to decrease the exposure to ombitasvir.
▶ Rifampicin is predicted to decrease the exposure to
▶ Rifampicin is predicted to decrease the exposure to opioids
▶ Rifampicin is predicted to decrease the exposure to opioids
(buprenorphine). Monitor and adjust dose.oTheoretical
▶ Rifampicin decreases the exposure to opioids (codeine,
▶ Rifampicin decreases the exposure to opioids (methadone).
Monitor and adjust dose.rStudy
▶ Rifampicin is predicted to decrease the exposure to opioids
(oxycodone). Monitor and adjust dose.oStudy
▶ Rifampicin is predicted to moderately decrease the exposure
▶ Rifampicin is predicted to moderately decrease the exposure
▶ Rifampicin is predicted to decrease the exposure to palbociclib.
▶ Rifampicin is predicted to decrease the exposure to
paliperidone. Monitor and adjust dose.rStudy
▶ Rifampicin is predicted to decrease the exposure to
panobinostat. Avoid.oTheoretical
decreases the exposure to paracetamol.o ▶ Rifampicin is predicted to decrease the exposure to
(with ritonavir and ombitasvir). Avoid.r
▶ Rifampicin is predicted to decrease the exposure to pazopanib.
▶ Rifampicin is predicted to decrease the exposure to
phosphodiesterase type-5 inhibitors
▶ Rifampicin is predicted to decrease the exposure to
phosphodiesterase type-5 inhibitors
▶ Rifampicin is predicted to moderately to markedly decrease
the exposure to pibrentasvir. Avoid.rStudy
▶ Rifampicin moderately decreases the exposure to pioglitazone.
Monitor and adjust dose.oStudy
▶ Rifampicin is predicted to decrease the exposure to
pirfenidone. Avoid.oTheoretical
▶ Rifampicin is predicted to moderately decrease the exposure
▶ Rifampicin is predicted to decrease the exposure to ponatinib.
▶ Rifampicin is predicted to markedly decrease the exposure to
is predicted to decrease the exposure to quetiapine.
▶ Rifampicin slightly decreases the exposure to raltegravir.
—consult product literature.o ▶ Rifampicin is predicted to decrease the exposure to ranolazine.
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