Theoretical → Also see TABLE 15 p. 1378
Nabilone → see TABLE 11 p. 1377 (CNS depressant effects)
▶ Nabilone is predicted to increase the risk of cardiovascular
side-effects when given with amfetamines.rTheoretical
Nadolol → see beta blockers, non-selective
GENERAL INFORMATION Discontinue treatment 1 week before
anticipated use of opioids; if emergency analgesia is required
during treatment, an increased dose of opioid analgesic might
be necessary (monitor for opioid intoxication).
▶ Nalmefene is predicted to decrease the efficacy of opioids.
▶ Antiarrhythmics (dronedarone) are predicted to increase the
exposure to naloxegol. Adjust naloxegol dose and monitor side
▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone) are predicted to markedly decrease the
exposure to naloxegol. Avoid.oStudy
▶ Antifungals, azoles (fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure to naloxegol. Adjust
naloxegol dose and monitor side effects, p. 65.oStudy
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to markedly increase the exposure to naloxegol.
▶ Apalutamide is predicted to decrease the exposure to
naloxegol. Avoid or monitor.oStudy
▶ Aprepitant is predicted to increase the exposure to naloxegol.
increase the exposure to naloxegol. Adjust naloxegol dose and
monitor side effects, p. 65.oStudy
▶ Cobicistat is predicted to markedly increase the exposure to
▶ Crizotinib is predicted to increase the exposure to naloxegol.
▶ Grapefruit juice is predicted to increase the exposure to
▶ HIV-protease inhibitors are predicted to markedly increase the
exposure to naloxegol. Avoid.rStudy
▶ Idelalisib is predicted to markedly increase the exposure to
▶ Imatinib is predicted to increase the exposure to naloxegol.
the exposure to naloxegol. Avoid.rStudy
▶ Macrolides (erythromycin) are predicted to increase the
exposure to naloxegol. Adjust naloxegol dose and monitor side
▶ Mitotane is predicted to markedly decrease the exposure to
▶ Netupitant is predicted to increase the exposure to naloxegol.
▶ St John’s Wort is predicted to decrease the exposure to
GENERAL INFORMATION Avoid concurrent use of opioids.
▶ Nandrolone is predicted to increase the anticoagulant effect of
coumarins. Monitor and adjust dose.rTheoretical
1498 Monoclonal antibodies — Nandrolone BNF 78
▶ Nandrolone is predicted to increase the anticoagulant effect of
phenindione. Monitor and adjust dose.rTheoretical
Naratriptan → see TABLE 13 p. 1378 (serotonin syndrome)
▶ Naratriptan is predicted to increase the risk of
vasoconstriction when given with ergotamine. Separate
administration by 24 hours.rTheoretical
Natalizumab → see monoclonal antibodies
Nateglinide → see TABLE 14 p. 1378 (antidiabetic drugs)
▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone) are predicted to slightly decrease the
exposure to nateglinide.nStudy
▶ Enzalutamide is predicted to slightly decrease the exposure to
▶ Leflunomide is predicted to increase the exposure to
▶ Mitotane is predicted to slightly decrease the exposure to
▶ Rifampicin is predicted to slightly decrease the exposure to
▶ Teriflunomide is predicted to increase the exposure to
Nebivolol → see beta blockers, selective
Necitumumab → see monoclonal antibodies
Nefopam → see TABLE 10 p. 1377 (antimuscarinics)
▶ Nefopam is predicted to increase the risk of serious elevations
in blood pressure when given with monoamine-oxidase A and B
inhibitors, irreversible. Avoid.rTheoretical
Nelarabine → see TABLE 15 p. 1378 (myelosuppression)
Neomycin → see TABLE 2 p. 1375 (nephrotoxicity), TABLE 19 p. 1379
(ototoxicity), TABLE 20 p. 1379 (neuromuscular blocking effects)
ROUTE-SPECIFIC INFORMATION Since systemic absorption can
follow topical application, the possibility of interactions
▶ Neomycin decreases the absorption of digoxin.oStudy
moderately decreases the exposure to sorafenib.
Neostigmine → see TABLE 6 p. 1376 (bradycardia)
▶ Aminoglycosides are predicted to decrease the effects of
▶ Netupitant is predicted to increase the exposure to
▶ Netupitant is predicted to increase the exposure to aldosterone
(eplerenone). Adjust eplerenone dose, p. 193.r
▶ Netupitant very slightly increases the exposure to alkylating
agents (cyclophosphamide).oStudy
▶ Netupitant is predicted to increase the exposure to alkylating
▶ Netupitant is predicted to increase the exposure to alpha
blockers (tamsulosin).oTheoretical
is predicted to increase the exposure to alprazolam.
▶ Netupitant is predicted to increase the exposure to
(propafenone). Monitor and adjust dose.
▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone) are predicted to decrease the exposure
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the exposure to
netupitant.o ▶ Netupitant is predicted to decrease the exposure to antifungals,
azoles (isavuconazole).oTheoretical
▶ Netupitant is predicted to increase the exposure to
antihistamines, non-sedating (mizolastine).rTheoretical
▶ Netupitant is predicted to increase the exposure to
antihistamines, non-sedating (rupatadine). Avoid.oStudy
▶ Netupitant is predicted to increase the concentration of
antimalarials (piperaquine).rTheoretical
is predicted to increase the exposure to axitinib.
▶ Netupitant is predicted to increase the exposure to
bedaquiline. Avoid prolonged use.nTheoretical
▶ Netupitant is predicted to increase the exposure to beta2
is predicted to decrease the exposure to netupitant.
▶ Netupitant is predicted to increase the exposure to bosutinib.
Avoid or adjust dose.rTheoretical
▶ Netupitant is predicted to increase the exposure to buspirone.
Use with caution and adjust dose.oStudy
▶ Netupitant is predicted to increase the exposure to
▶ Netupitant is predicted to increase the exposure to calcium
channel blockers (amlodipine, felodipine, lacidipine,
lercanidipine, nicardipine, nifedipine, nimodipine). Monitor and
▶ Netupitant is predicted to increase the exposure to cariprazine.
is predicted to increase the exposure to ceritinib.
▶ Netupitant is predicted to increase the concentration of
is predicted to increase the exposure to netupitant.
▶ Netupitant is predicted to increase the exposure to
▶ Netupitant is predicted to increase the exposure to colchicine.
Adjust colchicine dose with moderate inhibitors of CYP3A4,
▶ Netupitant is predicted to increase the exposure to oral
corticosteroids (budesonide).oStudy
▶ Netupitant is predicted to increase the exposure to
corticosteroids (dexamethasone). Adjust dose.oStudy
▶ Netupitant is predicted to increase the exposure to
corticosteroids (fluticasone).oStudy
▶ Netupitant is predicted to increase the exposure to
(methylprednisolone). Monitor and adjust dose.
▶ Netupitant is predicted to slightly increase the exposure to
is predicted to increase the exposure to dasatinib.
▶ Netupitant increases the risk of QT-prolongation when given
with domperidone. Avoid.rStudy
▶ Netupitant is predicted to increase the exposure to dopamine
receptor agonists (bromocriptine).rTheoretical
▶ Netupitant is predicted to increase the concentration of
dopamine receptor agonists (cabergoline).oAnecdotal
▶ Netupitant is predicted to moderately increase the exposure to
is predicted to decrease the exposure to netupitant.
is predicted to increase the exposure to eletriptan.
▶ Netupitant is predicted to increase the exposure to eliglustat.
Avoid or adjust dose—consult product literature.rStudy
▶ Netupitant is predicted to moderately increase the exposure to
▶ Enzalutamide is predicted to decrease the exposure to
▶ Netupitant is predicted to increase the risk of ergotism when
given with ergometrine.rTheoretical
▶ Netupitant is predicted to increase the risk of ergotism when
given with ergotamine.rTheoretical
is predicted to increase the exposure to erlotinib.
slightly increases the exposure to etoposide.
▶ Netupitant is predicted to increase the concentration of
everolimus. Avoid or adjust dose.oStudy
▶ Netupitant is predicted to increase the exposure to
fesoterodine. Adjust fesoterodine dose with moderate
inhibitors of CYP3A4 in hepatic and renal impairment, p. 777.
BNF 78 Nandrolone — Netupitant 1499
is predicted to increase the exposure to gefitinib.
▶ Netupitant is predicted to increase the concentration of
guanfacine. Adjust guanfacine dose, p. 352.oTheoretical
▶ HIV-protease inhibitors are predicted to increase the exposure
▶ Netupitant is predicted to increase the exposure to ibrutinib.
Adjust ibrutinib dose with moderate inhibitors of CYP3A4,
is predicted to increase the exposure to netupitant.
is predicted to increase the exposure to imatinib.
is predicted to increase the exposure to irinotecan.
▶ Netupitant is predicted to increase the exposure to ivabradine.
Adjust ivabradine dose, p. 211.rTheoretical
▶ Netupitant is predicted to increase the exposure to ivacaftor.
Adjust ivacaftor p. 293 or tezacaftor with ivacaftor p. 295 dose
with moderate inhibitors of CYP3A4.rStudy
is predicted to increase the exposure to lapatinib.
▶ Netupitant is predicted to increase the exposure to lomitapide.
▶ Netupitant is predicted to increase the exposure to lurasidone.
Adjust lurasidone dose, p. 398.oStudy
▶ Macrolides (clarithromycin) are predicted to increase the
is predicted to increase the exposure to maraviroc.
▶ Netupitant is predicted to increase the exposure to midazolam.
Monitor side effects and adjust dose.rStudy
▶ Netupitant is predicted to increase the exposure to
▶ Mitotane is predicted to decrease the exposure to netupitant.
▶ Netupitant is predicted to increase the exposure to naloxegol.
naloxegol dose and monitor side effects, p. 65.o ▶ Nevirapine
is predicted to decrease the exposure to netupitant.
is predicted to increase the exposure to nilotinib.
▶ Netupitant is predicted to increase the exposure to olaparib.
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