pomalidomide. Adjust pomalidomide dose, p. 961.
▶ SSRIs (fluvoxamine) moderately increase the exposure to
pomalidomide. Adjust pomalidomide dose, p. 961.oStudy
▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone) are predicted to decrease the exposure
to ponatinib. Avoid.oTheoretical
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to slightly increase the exposure to ponatinib.
Monitor and adjust ponatinib dose, p. 994.oStudy
▶ Cobicistat is predicted to slightly increase the exposure to
when given with coumarins.rTheoretical
▶ Enzalutamide is predicted to decrease the exposure to
▶ Grapefruit juice is predicted to increase the exposure to
▶ HIV-protease inhibitors are predicted to slightly increase the
exposure to ponatinib. Monitor and adjust ponatinib dose,
▶ Idelalisib is predicted to slightly increase the exposure to
the exposure to ponatinib. Monitor and adjust ponatinib dose,
▶ Mitotane is predicted to decrease the exposure to ponatinib.
▶ Ponatinib is predicted to increase the risk of bleeding events
when given with phenindione.rTheoretical
▶ Rifampicin is predicted to decrease the exposure to ponatinib.
▶ St John’s Wort is predicted to decrease the exposure to
1516 Pitolisant — Ponatinib BNF 78
Posaconazole → see antifungals, azoles
Potassium aminobenzoate → see TABLE 16 p. 1379 (increased serum
▶ Potassium aminobenzoate increases the concentration of
▶ Potassium aminobenzoate is predicted to affect the efficacy of
sulfonamides. Avoid.rTheoretical
Potassium canrenoate → see TABLE 16 p. 1379 (increased serum
Potassium chloride → see TABLE 16 p. 1379 (increased serum
▶ Potassium citrate is predicted to decrease the efficacy of
methenamine. Avoid.oTheoretical
▶ Potassium citrate increases the risk of side-effects when given
with sucralfate. Avoid.oTheoretical
Potassium-sparing diuretics → see TABLE 18 p. 1379
(hyponatraemia), TABLE 16 p. 1379 (increased serum potassium)
amiloride .triamterene. ▶ Triamterene
potentially increases the clearance of lithium.
Pramipexole → see dopamine receptor agonists
Prasugrel → see TABLE 4 p. 1375 (antiplatelet effects)
▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone) are predicted to markedly decrease the
exposure to praziquantel. Avoid.oStudy
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to moderately increase the exposure to
▶ Antimalarials (chloroquine) moderately decrease the exposure
▶ Corticosteroids (dexamethasone) decrease the exposure to
▶ Enzalutamide is predicted to markedly decrease the exposure
▶ Grapefruit juice is predicted to increase the exposure to
▶ H2 receptor antagonists (cimetidine) moderately increase the
exposure to praziquantel.oStudy
▶ HIV-protease inhibitors are predicted to moderately increase
the exposure to praziquantel.nStudy
▶ Idelalisib is predicted to moderately increase the exposure to
▶ Macrolides (clarithromycin) are predicted to moderately
increase the exposure to praziquantel.nStudy
▶ Mitotane is predicted to markedly decrease the exposure to
▶ Rifampicin is predicted to markedly decrease the exposure to
Prednisolone → see corticosteroids
Pregabalin → see antiepileptics
Prilocaine → see anaesthetics, local
Primaquine → see antimalarials
Primidone → see antiepileptics
Procarbazine → see TABLE 15 p. 1378 (myelosuppression), TABLE 13
foods (such as mature cheese, salami, pickled herring, Bovril ®,
Oxo ®, Marmite ® or any similar meat or yeast extract or
fermented soya bean extract, and some beers, lagers or
▶ Alcohol (beverage) potentially causes a disulfiram-like
reaction when given with procarbazine.oAnecdotal
▶ Antiepileptics (carbamazepine, phenobarbital, phenytoin,
primidone) are predicted to increase the risk of
hypersensitivity reactions when given with
▶ Antiepileptics (fosphenytoin) are predicted to increase the risk
of hypersensitivity when given with
▶ Live vaccines are predicted to increase the risk of generalised
infection (possibly life-threatening) when given with
procarbazine. Public Health England advises avoid (refer to
Prochlorperazine → see phenothiazines
Procyclidine → see TABLE 10 p. 1377 (antimuscarinics)
▶ SSRIs (paroxetine) slightly increase the exposure to
procyclidine. Monitor and adjust dose.oStudy
Promazine → see phenothiazines
Promethazine → see antihistamines, sedating
Propafenone → see antiarrhythmics
Propantheline → see TABLE 10 p. 1377 (antimuscarinics)
Propiverine → see TABLE 10 p. 1377 (antimuscarinics)
▶ Propiverine is predicted to increase the exposure to
. Separate administration by 12 hours.o
Propofol → see TABLE 8 p. 1376 (hypotension), TABLE 11 p. 1377 (CNS
▶ Antiepileptics (valproate) potentially increase the
concentration of propofol. Adjust dose.rTheoretical
Propranolol → see beta blockers, non-selective
Propylthiouracil → see TABLE 15 p. 1378 (myelosuppression)
▶ Propylthiouracil is predicted to decrease the effects of
metyrapone. Avoid.oTheoretical
proton pump inhibitors (esomeprazole, omeprazole). Adjust
▶ Proton pump inhibitors decrease the absorption of antifungals,
azoles (itraconazole). Administer itraconazole capsules with an
▶ Proton pump inhibitors decrease the absorption of antifungals,
azoles (ketoconazole). Administer ketoconazole with an acidic
▶ Proton pump inhibitors decrease the absorption of antifungals,
azoles (posaconazole) (oral suspension). Avoid.oStudy
▶ Apalutamide markedly decreases the exposure to omeprazole.
▶ Apalutamide is predicted to decrease the exposure to proton
pump inhibitors (lansoprazole, rabeprazole). Avoid or monitor.
▶ Proton pump inhibitors are predicted to decrease the
absorption of bosutinib.oStudy
▶ Proton pump inhibitors are predicted to decrease the
absorption of ceritinib.oTheoretical
▶ Esomeprazole is predicted to increase the exposure to
▶ Omeprazole is predicted to increase the exposure to cilostazol.
Adjust cilostazol dose, p. 232.oStudy
▶ Proton pump inhibitors (esomeprazole, omeprazole) potentially
clobazam. Adjust dose.o ▶ Proton pump inhibitors (esomeprazole, omeprazole) are
▶ Proton pump inhibitors are predicted to slightly to moderately
decrease the exposure to dasatinib. Avoid.rStudy
▶ Proton pump inhibitors are predicted to decrease the
dipyridamole (immediate release tablets).
▶ Proton pump inhibitors are predicted to slightly decrease the
exposure to erlotinib. Avoid.oStudy
▶ Proton pump inhibitors are predicted to decrease the exposure
▶ HIV-protease inhibitors (tipranavir) decrease the exposure to
proton pump inhibitors. Avoid.rStudy
▶ Proton pump inhibitors decrease the exposure to HIV-protease
inhibitors (atazanavir). Avoid or adjust dose.rStudy
BNF 78 Posaconazole — Proton pump inhibitors 1517
Proton pump inhibitors (continued)
▶ Proton pump inhibitors increase the exposure to HIV-protease
inhibitors (saquinavir). Avoid.rStudy
▶ Proton pump inhibitors are predicted to decrease the exposure
ledipasvir. Adjust dose, see ledipasvir with sofosbuvir p. 628.
▶ Proton pump inhibitors decrease the clearance of methotrexate
(high-dose). Use with caution or avoid.rStudy
▶ Proton pump inhibitors are predicted to decrease the exposure
pazopanib. Avoid or administer concurrently without food.
▶ Proton pump inhibitors are predicted to decrease the exposure
▶ Proton pump inhibitors potentially decrease the exposure to
sofosbuvir. Adjust dose, see ledipasvir with sofosbuvir p. 628,
sofosbuvir with velpatasvir p. 629, and sofosbuvir with
velpatasvir and voxilaprevir p. 630.oStudy
▶ Esomeprazole is predicted to slightly to moderately increase
the exposure to SSRIs (citalopram, escitalopram). Monitor and
▶ Omeprazole slightly to moderately increases the exposure to
rSSRIs (citalopram, escitalopram). Monitor and adjust dose.
▶ Proton pump inhibitors are predicted to decrease the
concentration of velpatasvir. Adjust dose, see sofosbuvir with
▶ Proton pump inhibitors are predicted to decrease the exposure
to voxilaprevir. Adjust dose, see sofosbuvir with velpatasvir and
Proxymetacaine → see anaesthetics, local
Pseudoephedrine → see sympathomimetics, vasoconstrictor
▶ Allopurinol is predicted to increase the risk of hyperuricaemia
when given with pyrazinamide.oTheoretical
Pyridostigmine → see TABLE 6 p. 1376 (bradycardia)
▶ Aminoglycosides are predicted to decrease the effects of
Pyrimethamine → see antimalarials
Quetiapine → see TABLE 8 p. 1376 (hypotension), TABLE 11 p. 1377 (CNS
▶ Antiarrhythmics (dronedarone) are predicted to increase the
exposure to quetiapine. Avoid.oStudy
▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone) are predicted to decrease the exposure
to quetiapine.oStudy → Also see TABLE 11 p. 1377
▶ Antiepileptics (valproate) potentially increase the risk of
neutropenia when given with quetiapine.oStudy
▶ Antifungals, azoles (fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure to
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the exposure to
▶ Apalutamide is predicted to decrease the exposure to
quetiapine. Avoid or monitor.oStudy
▶ Aprepitant is predicted to increase the exposure to quetiapine.
is predicted to decrease the exposure to quetiapine.
▶ Calcium channel blockers (diltiazem, verapamil) are predicted to
increase the exposure to quetiapine. Avoid.oStudy →
▶ Cobicistat is predicted to increase the exposure to quetiapine.
▶ Crizotinib is predicted to increase the exposure to quetiapine.
▶ Quetiapine is predicted to decrease the effects of dopamine
receptor agonists. Avoid.oTheoretical → Also see TABLE 8
is predicted to decrease the exposure to quetiapine.
▶ Enzalutamide is predicted to decrease the exposure to
▶ Grapefruit juice is predicted to increase the exposure to
quetiapine. Avoid.rTheoretical
▶ HIV-protease inhibitors are predicted to increase the exposure
▶ Idelalisib is predicted to increase the exposure to quetiapine.
▶ Imatinib is predicted to increase the exposure to quetiapine.
▶ Quetiapine potentially increases the risk of neurotoxicity
when given with lithium.rAnecdotal
▶ Macrolides (clarithromycin) are predicted to increase the
exposure to quetiapine. Avoid.rStudy
▶ Macrolides (erythromycin) are predicted to increase the
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