117

CONCLUSION

Given the complexities of data on drug interactions and the complexities within the

healthcare systems, healthcare providers have become increasingly challenged on

devising optimal approaches to managing drug interactions.

3 Patient safety initiatives

have expanded in efforts to improve the healthcare delivery system with medication

error prevention as a high-priority area. Medication errors may be related to

professional practice, healthcare products, procedures, and systems, including

prescribing, order communication, product labeling, packaging, nomenclature,

compounding, dispensing, distribution, administration, education, monitoring, and

use.

2,4 Because exposure to drug–drug interactions is a significant source of

preventable drug-related harm, appropriate medication use, including drug

interaction management, will avoid medication errors.

5

Although the majority of drug interactions are clinically insignificant, in certain

circumstances drug interactions are considered to be highly significant and can cause

harm. Patients should be informed of the importance of maintaining a complete

medication

p. 49

p. 50

profile including over-the-counter medications, herbs, and dietary supplements.

The incorporation of pharmacogenetic information into risk assessment of patients

will improve our ability to prevent DDIs and to better evaluate interactions with

biologic drugs.

More well-controlled studies are needed after drug approvals. Population-based

studies are useful to determine the severity of, incidence of, and clinical importance

of drug interactions. Pharmacogenetic research can further improve the precision of

DDE evidence and CDS by identifying patient-specific predisposing factors. Future

directives will identify the most appropriate process to rate the quality of DDI

evidence and provided graded recommendations to reduce the risk of adverse

consequences.

5

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