Daniel R. Malcolm, PharmD, BCPS, BCCCP

Associate Professor and Vice-Chair

Clinical and Administrative Services

Sullivan University College of Pharmacy

Louisville, Kentucky

Shannon F. Manzi, PharmD, NREMT, FPPAG

Director, Clinical Pharmacogenomics Service

Manager, Emergency and ICU Pharmacy Services

Boston Children’s Hospital

Boston, Massachusetts

Joel C. Marrs, PharmD, FCCP, FASHP, FNLA, BCPS-AQ Cardiology, BCACP,

CLS, ASH-CHC

Associate Professor

Department of Clinical Pharmacy

University of Colorado Anschutz Medical Campus

Skaggs School of Pharmacy and Pharmaceutical Sciences

Clinical Pharmacy Specialist

Department of Pharmacy

Denver Health and Hospital Authority

Aurora, Colorado

John Marshall, PharmD, BCPS, BCCCP, FCCM

Clinical Pharmacy Coordinator–Critical Care

Beth Israel Deaconess Medical Center

Boston, Massachusetts

Darius L. Mason, PharmD, BCPS, FACN

Clinical Pharmacist

Methodist South Hospital

Memphis, Tennessee

Susan L. Mayhew, PharmD, BCNSP, FASHP

Professor and Dean

Appalachian College of Pharmacy

Oakwood, Virginia

James W. McAuley, RPh, PhD, FAPhA

Associate Dean for Academic Affairs and Professor

Departments of Pharmacy Practice and Neurology

The Ohio State University College of Pharmacy

Columbus, Ohio

Sarah E. McBane, PharmD, CDE, BCPS, FCCP, FCPhA, APh

Professor and Chair

Department of Pharmacy Practice

West Coast University

Los Angeles, California

William W. McCloskey, BA, BS, PharmD

Professor of Pharmacy Practice

School of Pharmacy–Boston

MCPHS University

Boston, Massachusetts

Chephra McKee, PharmD

Assistant Professor of Pharmacy Practice

School of Pharmacy

Pediatrics Division

Texas Tech University Health Sciences Center

Abilene, Texas

Molly G. Minze, PharmD, BCACP

Associate Professor of Pharmacy Practice

Ambulatory Care Division

School of Pharmacy

Texas Tech University Health Sciences Center

Abilene, Texas

Amee D. Mistry, PharmD

Associate Professor Pharmacy Practice

School of Pharmacy–Boston

MCPHS University

Boston, Massachusetts

p. xvii

p. xviii

Katherine G. Moore, PharmD, BCPS, BCACP

Executive Director of Experiential Education

Associate Professor of Pharmacy Practice

Presbyterian College School of Pharmacy

Clinton, South Carolina

Jill A. Morgan, PharmD, BCPS, BCPPS

Associate Professor and Chair

Department of Pharmacy Practice and Science

University of Maryland School of Pharmacy

Baltimore, Maryland

Anna K. Morin, PharmD

Professor of Pharmacy Practice and Dean

School of Pharmacy–Worcester/Manchester

MCPHS University

Worcester, Massachusetts

Pamela B. Morris, MD, FACC, FAHA, FASPC, FNLA

Director, Seinsheimer Cardiovascular Health Program

Co-Director, Women’s Heart Care

Medical University of South Carolina

Charleston, South Carolina

Oussayma Moukhachen, PharmD, BCPS

Assistant Professor Pharmacy Practice

School of Pharmacy–Boston

MCPHS University

Boston, Massachusetts

Clinical Care Specialist

Mount Auburn Hospital

Cambridge, Massachusetts

Kelly A. Mullican, PharmD

Primary Care Clinical Pharmacy Specialist

Kaiser Permanente–Mid-Atlantic States

Washington, District of Columbia

Myrna Y. Munar, PharmD

Associate Professor of Pharmacy

College of Pharmacy

Oregon State University

Oregon Health and Science University

Portland, Oregon

Yulia A. Murray, PharmD, BCPS

Assistant Professor of Pharmacy Practice

School of Pharmacy–Boston

MCPHS University

Boston, Massachusetts

Milap C. Nahata, MS, PharmD, FCCP, FAPhA, FASHP

Director, Institute of Therapeutic Innovations and Outcomes

Professor Emeritus of Pharmacy, Pediatrics, and Internal Medicine

Colleges of Pharmacy and Medicine

The Ohio State University

Columbus, Ohio

Richard S. Nicholas, PharmD, ND, CDE, BCPS, BCACP

Assistant Professor of Pharmacy Practice

Appalachian College of Pharmacy

Oakwood, Virginia

Stefanie C. Nigro, PharmD, BCACP, BC-ADM

Assistant Professor of Pharmacy Practice

School of Pharmacy–Boston

MCPHS University

Boston, Massachusetts

Cindy L. O’Bryant, PharmD, BCOP, FCCP, FHOPA

Professor

Department of Clinical Pharmacy

Skaggs School of Pharmacy and Pharmaceutical Sciences

Clinical Pharmacy Specialist in Oncology

University of Colorado Cancer Center

Aurora, Colorado

Kirsten H. Ohler, PharmD, BCPS, BCPPS

Clinical Assistant Professor of Pharmacy Practice

College of Pharmacy

University of Illinois at Chicago

Clinical Pharmacy Specialist–Neonatal ICU

University of Illinois at Chicago Hospital and Health Sciences System

Chicago, Illinois

Julie L. Olenak, PharmD

Assistant Dean of Student Affairs

Associate Professor

Department of Pharmacy Practice

Nesbitt College of Pharmacy and Nursing

Wilkes University

Wilkes-Barre, Pennsylvania

Jacqueline L. Olin, MS, PharmD, BCPS, CDE, FASHP, FCCP

Professor of Pharmacy

School of Pharmacy

Wingate University

Wingate, North Carolina

Neeta Bahal O’Mara, PharmD, BCPS

Clinical Pharmacist

Dialysis Clinic, Inc.

North Brunswick, New Jersey

Robert L. Page, II, PharmD, MSPH, FHFSA, FCCP, FASHP, FASCP, CGP,

BCPS (AQ-Cards)

Professor

Departments of Clinical Pharmacy and Physical Medicine

School of Pharmacy and Pharmaceutical Sciences

University of Colorado

Aurora, Colorado

Louise Parent-Stevens, PharmD, BCPS

Assistant Director of Introductory Pharmacy Practice Experiences

Clinical Assistant Professor

Department of Pharmacy Practice

University of Illinois at Chicago College of Pharmacy

Chicago, Illinois

Dhiren K. Patel, PharmD, CDE, BC-ADM, BCACP

Associate Professor of Pharmacy Practice

School of Pharmacy–Boston

MCPHS University

Boston, Massachusetts

Katherine Tipton Patel, PharmD, BCOP

Clinical Pharmacy Specialist

The University of Texas

MD Anderson Cancer Center

Houston, Texas

p. xviii

p. xix

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Associate Training Director

Child and Adolescent Psychiatry Fellowship

Primary Care Mental Health Integrated Psychiatrist

Cambridge Health Alliance

Cambridge, Massachusetts

Charmaine Rochester-Eyeguokan, PharmD, BCPS, BCACP, CDE

Associate Professor of Pharmacy Practice and Science

University of Maryland School of Pharmacy

Baltimore, Maryland

Carol J. Rollins, PharmD, MS, RD, CNSC, BCNSP

Clinical Associate Professor

Department of Pharmacy Practice and Science

College of Pharmacy

The University of Arizona

Tucson, Arizona

Melody Ryan, PharmD, MPH, GCP, BCPS

Professor

Department of Pharmacy Practice and Science

College of Pharmacy

University of Kentucky

Lexington, Kentucky

David Schnee, PharmD, BCACP

Associate Professor of Pharmacy Practice

School of Pharmacy–Boston

MCPHS University

Boston, Massachusetts

Eric F. Schneider, BS Pharm, PharmD

Assistant Dean for Academics

Professor

School of Pharmacy

Wingate University

Wingate, North Carolina

Sheila Seed, PharmD, MPH

Professor of Pharmacy Practice

School of Pharmacy–Worcester/Manchester

MCPHS University

Worcester, Massachusetts

Timothy H. Self, PharmD

Professor of Clinical Pharmacy

College of Pharmacy

University of Tennessee Health Science Center

Memphis, Tennessee

Amy Hatfield Seung, PharmD, BCOP

Senior Director of Clinical Development

Physician Resource Management/Caret

Cary, North Carolina

Nancy L. Shapiro, PharmD, FCCP, BCPS

Operations Coordinator

University of Illinois Hospital and Health Sciences System

Clinical Associate Professor of Pharmacy Practice

Director, PGY2 Ambulatory Care Residency

College of Pharmacy

University of Illinois at Chicago

Chicago, Illinois

Iris Sheinhait, PharmD, MA, RPh

Certified Poison Information Specialist

Adjunct Assistant Professor

Regional Center for Poison Control Serving Massachusetts and Rhode Island

Boston Children’s Hospital and MCPHS University

Boston, Massachusetts

Greene Shepherd, PharmD, DABAT

Clinical Professor and Vice-Chair

Division of Practice Advancement and Clinical Education

Director of Professional Education, Asheville Campus

Eshelman School of Pharmacy

University of North Carolina at Chapel Hill

Asheville, North Carolina

Devon A. Sherwood, PharmD, BCPP

Assistant Professor

Psychopharmacology

College of Pharmacy

University of New England

Portland, Maine

p. xix

p. xx

Richard J. Silvia, PharmD, BCCP

Associate Professor of Pharmacy Practice

School of Pharmacy–Boston

MCPHS University

Boston, Massachusetts

Carrie A. Sincak, PharmD, BCPS, FASHP

Assistant Dean for Clinical Affairs and Professor

Department of Pharmacy Practice

Midwestern University Chicago College of Pharmacy

Downers Grove, Illinois

Harleen Singh, PharmD, BCPS-AQ Cardiology, BCACP

Clinical Associate Professor of Pharmacy Practice

Oregon State University

Oregon Health and Science University

Portland, Oregon

Jessica C. Song, MA, PharmD

Clinical Pharmacy Supervisor

PGY1 Pharmacy Residency Coordinator

Department of Pharmacy Services

Santa Clara Valley Medical Center

San Jose, California

Suellyn J. Sorensen, PharmD, BCPS, FASHP

Director

Clinical Pharmacy Services

St. Vincent Indianapolis

Indianapolis, Indiana

Linda M. Spooner, PharmD, BCPS (AQ-ID), FASHP

Professor of Pharmacy Practice

School of Pharmacy–Worcester/Manchester

MCPHS University

Clinical Pharmacy Specialist in Infectious Diseases

Saint Vincent Hospital

Worcester, Massachusetts

Karyn M. Sullivan, PharmD, MPH

Professor of Pharmacy Practice

School of Pharmacy–Worcester/Manchester

MCPHS University

Worcester, Massachusetts

David J. Taber, PharmD, MS, BCPS

Associate Professor

Division of Transplant Surgery

College of Medicine

Medical University of South Carolina

Charleston, South Carolina

Candace Tan, PharmD, BCACP

Clinical Pharmacist

Kaiser Permanente

Los Angeles, California

Yasar O. Tasnif, PharmD, BCPS, FAST

Associate Professor

Cooperative Pharmacy Program

University of Texas at Austin and University of Texas, Rio Grande Valley

Clinical Pharmacist Specialist

Doctor’s Hospital at Renaissance–Renaissance Transplant Institute

Edinburg, Texas

Daniel J. G. Thirion, BPharm, MSc, PharmD, FCSHP

Professeur Titulaire de Clinique

Faculté de Pharmacie

Université de Montréal

Pharmacien

Centre Universitaire de Santé McGill

Montréal, Québec, Canada

Angela M. Thompson, PharmD, BCPS

Assistant Professor

Department of Clinical Pharmacy

Skaggs School of Pharmacy and Pharmaceutical Sciences

University of Colorado

Aurora, Colorado

Lisa A. Thompson, PharmD, BCOP

Clinical Pharmacy Specialist in Oncology

Kaiser Permanente Colorado

Lafayette, Colorado

Toyin Tofade, MS, PharmD, BCPS, CPCC

Dean and Professor

Howard University College of Pharmacy

Washington, District of Columbia

Tran H. Tran, PharmD, BCPS

Associate Professor

Midwestern University, Chicago College of Pharmacy

Downers Grove, Illinois

Dominick P. Trombetta, PharmD, BCPS, CGP, FASCP

Associate Professor

Department of Pharmacy Practice

Nesbitt School of Pharmacy

Wilkes University

Wilkes-Barre, Pennsylvania

Toby C. Trujillo, PharmD, FCCP, FAHAH, BCPS-AQ Cardiology

Associate Professor

Department of Clinical Pharmacy

Skaggs School of Pharmacy and Pharmaceutical Sciences

University of Colorado

Aurora, Colorado

Sheila K. Wang, PharmD, BCPS (AQ–ID)

Associate Professor of Pharmacy Practice

Chicago College of Pharmacy

Midwestern University

Downers Grove, Illinois

Clinical Pharmacist, Infectious Disease

Program Director, Rush University Medical Center

Chicago, Illinois

Brian Watson, PharmD, BCPS

Pharmacist

University of Maryland Medical System

St. Joseph’s Medical Center

Baltimore, Maryland

Kristin Watson, PharmD, BCPS-AQ Cardiology

Associate Professor, Vice-Chair of Clinical Services

University of Maryland School of Pharmacy

Baltimore, Maryland

p. xx

p. xxi

Lynn Weber, PharmD, BCOP

Clinical Pharmacy Specialist, Oncology/Hematology

Pharmacy Residency Coordinator and PGY-1 Residency Director

Hennepin County Medical Center

Minneapolis, Minnesota

Kellie Jones Weddle, PharmD, BCOP, FCCP, FHOPA

Clinical Professor of Pharmacy Practice

College of Pharmacy

Purdue University

Indianapolis, Indiana

C. Michael White, PharmD, FCP, FCCP

Professor and Head

Department of Pharmacy Practice

School of Pharmacy

University of Connecticut

Storrs, Connecticut

Natalie Whitmire, PharmD, BCPS, BCGP

Pharmacist Specialist

University of California, San Diego Health

Barbara S. Wiggins, PharmD, BCPS, CLS, AACC, FAHA, FCCP, FNLA

Clinical Pharmacy Specialist–Cardiology

Medical University of South Carolina

Charleston, South Carolina

Kristine C. Willett, PharmD, FASHP

Associate Professor of Pharmacy Practice

School of Pharmacy–Worcester/Manchester

MCPHS University

Manchester, New Hampshire

Bradley R. Williams, PharmD, CGP

Professor of Clinical Pharmacy and Clinical Gerontology

School of Pharmacy

University of Southern California

Los Angeles, California

Casey B. Williams, PharmD, BCOP, FHOPA

Director, Center for Precision Oncology

Director, Department of Molecular and Experimental Medicine

Avera Cancer Institute

Sioux Falls, South Dakota

Dennis M. Williams, PharmD, BCPS, AE-C

Associate Professor and Vice-Chair for Professional Education and Practice

Division of Pharmacotherapy and Experimental Therapeutics

Eshelman School of Pharmacy

University of North Carolina at Chapel Hill

Chapel Hill, North Carolina

Katie A. Won, PharmD, BCOP

Clinical Pharmacist

Hennepin County Medical Center

Minneapolis, Minnesota

Annie Wong-Beringer, PharmD, FIDSA

Professor of Pharmacy

School of Pharmacy

University of Southern California

Los Angeles, California

Dinesh Yogaratnam, PharmD, BCPS, BCCCP

Assistant Professor of Pharmacy Practice

School of Pharmacy–Worcester/Manchester

MCPHS University

Worcester, Massachusetts

Kathy Zaiken, PharmD

Professor of Pharmacy Practice

School of Pharmacy–Boston

MCPHS University

Boston, Massachusetts

Caroline S. Zeind, PharmD

Associate Provost for Academic and International Affairs

Chief Academic Officer

Worcester, Massachusetts and Manchester, New Hampshire, Campuses

Professor of Pharmacy Practice

MCPHS University

Boston, Massachusetts

Sara Zhou, PharmD

Certified Poison Information Specialist

Adjunct Assistant Professor

Regional Center for Poison Control Serving Massachusetts and Rhode Island

Boston Children’s Hospital and MCPHS University

Boston, Massachusetts

Kristin M. Zimmerman, PharmD, CGP, BCACP

Associate Professor

Department of Pharmacotherapy & Outcomes Science

Virginia Commonwealth University

Richmond, Virginia

p. xxi

1

2

3

4

5

6

7

8

9

10

SECTION 1: GENERAL PRINCIPLES

Section Editors: William W. McCloskey and Maria D. Kostka-Rokosz

Medication Therapy Management and Assessment of Therapy

Matthew R. Machado, Amee D. Mistry, and Joseph W. Ferullo

Interpretation of Clinical Laboratory Tests

Erika Felix-Getzik, Yulia A. Murray, and Stefanie C. Nigro

Drug Interactions

Michelle L. Ceresia, Caroline S. Zeind, John Fanikos, and Michael G. Carvalho

Pharmacogenomics and Personalized Medicine

Shannon F. Manzi, Laura Chadwick, and Jonathan D. Picker

Managing Drug Overdoses and Poisonings

Iris Sheinhait and Sara Zhou

End-of-Life Care

Victoria F. Ferraresi

Interprofessional Education and Practice

William W. McCloskey, Edith Claros, Carol Eliadi, and Beth Buyea

SECTION 2: CARDIAC AND VASCULAR DISORDERS

Section Editors: Jean M. Nappi and Judy W. Cheng

Dyslipidemias, Atherosclerosis, and Coronary Heart Disease

Barbara S. Wiggins and Pamela B. Morris

Essential Hypertension

Judy W. Cheng

Peripheral Vascular Disorders

Snehal H. Bhatt and Mary G. Amato

11

12

13

14

15

16

17

18

19

20

21

22

23

Thrombosis

Nancy L. Shapiro and Erika L. Hellenbart

Chronic Stable Angina

Angela M. Thompson and Toby C. Trujillo

Acute Coronary Syndrome

Brianne L. Dunn and Robert L. Page, II

Heart Failure

Harleen Singh and Joel C. Marrs

Cardiac Arrhythmias

C. Michael White, Jessica C. Song, and James S. Kalus

Hypertensive Crises

Kristin Watson, Brian Watson, and Sandeep Devabhakthuni

Shock

Jason S. Haney

SECTION 3: PULMONARY DISORDERS

Section Editors: Timothy R. Hudd and Kathy Zaiken

Asthma

Timothy H. Self, Cary R. Chrisman, and Christopher K. Finch

Chronic Obstructive Pulmonary Disease

Timothy R. Hudd and Kathy Zaiken

Acute and Chronic Rhinitis

Suzanne G. Bollmeier and Dennis M. Williams

Cystic Fibrosis

Paul M. Beringer and Michelle Condren

SECTION 4: GASTROINTESTINAL DISORDERS

Section Editor: Carrie A. Sincak

Nausea and Vomiting

Lisa M. DiGrazia and Joseph Todd Carter

Upper Gastrointestinal Disorders

Elaine J. Law and Jeffrey J. Fong

24

25

26

27

28

29

30

31

32

33

34

Lower Gastrointestinal Disorders

Toyin Tofade, Benjamin Laliberte, and Charmaine Rochester-Eyeguokan

Complications of End-Stage Liver Disease

Yasar O. Tasnif and Mary F. Hebert

p. xxii

p. xxiii

SECTION 5: RENAL DISORDERS

Section Editor: Myrna Y. Munar

Acid–Base Disorders

Luis S. Gonzalez, III

Fluid and Electrolyte Disorders

Alan H. Lau and Priscilla P. How

Chronic Kidney Disease

Darius L. Mason

Acute Kidney Injury

Susan A. Krikorian and Oussayma Moukhachen

Renal Dialysis

Myrna Y. Munar

Dosing of Drugs in Renal Failure

David J. Quan

SECTION 6: IMMUNOLOGIC DISORDERS

Section Editor: Steven Gabardi

Drug Hypersensitivity Reactions

Greene Shepherd and Justinne Guyton

Systemic Lupus Erythematosus

Jerika T. Lam, Ann M. Lynch, and Mary A. Gutierrez

Kidney and Liver Transplantation

David J. Taber and Robert E. Dupuis

SECTION 7: NUTRITION ISSUES

35

36

37

38

39

40

41

42

43

44

45

46