applied therpeutics the clinical use of drugs . pdf

 

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The editors wish to express their sincere thanks to Dr. Mary

Anne Koda-Kimble and Dr. Lloyd Young who created

Applied Therapeutics, the gold standard textbook used in

the teaching of patient-centered drug therapeutics. Their

vision and legendary contributions have inspired

generations of health profession students, faculty, and

clinicians. We are grateful to the past editors and current

editorial team and contributors, as well as faculty

colleagues and clinicians across the globe for their

tremendous dedication to their patients and their

communities. They have shaped and inspired the next

generation of health care professionals through innovative

teaching, mentoring, and dissemination of their scholarship.

Finally, we wish to thank our families for their patience and

understanding as we embarked on this journey and

completed this eleventh edition of the textbook.

p. v

It has been over forty years since the first edition of Applied Therapeutics: The

Clinical Use of Drugs was published, and the landscape of health care has changed

dramatically. While we have seen tremendous scientific and technologic

advancements transform personalized medicine, we also realize the significant

challenges that we face within our increasingly complex health care delivery system.

More than ever, we are in need of health professionals who are able to think

critically and to utilize problem-solving skills to improve patient outcomes.

Approximately four decades later, the founding principle for this textbook—a

patient-centric, case-based approach to learning—remains the cornerstone of health

professions education. Our authors present approximately 900 patient cases that

stimulate the reader to integrate and apply therapeutic principles in the context of

specific clinical situations. Health profession students and practitioners gain a

glimpse into the minds of clinicians as they work to assess and solve therapeutic

problems and develop their own critical-thinking and problem-solving skills.

Readers familiar with past editions of the book will notice that the overall design

of the book is consistent with the tenth edition, which incorporates a Core Principles

section at the beginning of each chapter, providing the most important “take home”

information from the chapter. Each Core Principle is mapped to specific cases within

the chapter where the principle is discussed in detail. Key references and websites

are listed at the end of each chapter, whereas the full reference lists for each chapter

have been moved online.

Building upon the excellent foundation of case-based learning provided in

previous editions, the eleventh edition has incorporated changes to meet the evolving

educational needs of health profession educators and students across the globe. The

editors and contributors have utilized the five Institute of Medicine (IOM) core

competencies as a broad framework for proposing case studies and questions within

the textbook: patient-centered care; interdisciplinary teams; evidence-based practice;

quality improvement; and informatics. In addition, the Accreditation Council for

Pharmacy Education (ACPE) Accreditation Standards 2016, the Center for the

Advancement of Pharmacy Education (CAPE) Educational Outcomes, and the North

American Pharmacist Licensure Examination (NAPLEX) revised competency

statements have served as road maps for the editorial team and contributors in

designing the eleventh edition.

Featuring contributions from more than 200 experienced clinicians, every chapter

has been revised and updated to reflect our ever-changing knowledge of drugs and

the application of this knowledge to the individualized therapy of patients. Content

within several sections has been extensively reorganized, with new chapters

introduced to expand important topics. Among these are seven new chapters within

the General Principles, Immunologic Disorders, Rheumatic and Musculoskeletal

Diseases, Neurologic Disorders, Psychiatric Disorders & Substance Abuse, and

Hematology and Oncology sections. Of particular note are featured new chapters in

the General Principles section on Drug Interactions, Pharmacogenomics and

Personalized Medicine, and Interprofessional Education and Practice. In addition, a

chapter has been redesigned to focus on Care of the Critically Ill Adult, which now

complements the chapter on Care of the Critically Ill Child.

Given the importance of incorporating Interprofessional Education (IPE) within

the didactic, practicum, and clinical settings, we have added an array of IPE case

studies prepared by contributors that are representative of various sections of the

textbook. These IPE cases, along with answer guides, will be available for

instructors on the textbook’s website (see the “Additional Resources” section).

We welcome your feedback as we undertake planning for the next edition. The

authors have drawn on information from the literature, current standards, and their

own clinical experiences to share the process involved in making sound and

thoughtful therapeutic decisions. However, it remains the responsibility of every

practitioner to evaluate the appropriateness of a particular opinion in the context of

the actual clinical situation, bearing in mind any recent developments in the field. We

strongly urge students and practitioners to consult several appropriate information

sources when working with new and unfamiliar drugs.

p. vi

We are deeply indebted to the many dedicated people who have given of themselves

to complete the eleventh edition of Applied Therapeutics: The Clinical Use of Drugs.

We are grateful to our contributing authors who have worked tirelessly to provide the

highest quality of work, while balancing numerous responsibilities as educators,

clinicians, and researchers. We are grateful for the exceptional work of our twentysix section editors, who provided critical feedback necessary both in the

organizational structure of the textbook and in the individual editing of chapters;

without their dedication and support, this edition would not be possible. In

particular, we wish to recognize those returning section editors as they have been a

guiding force for the eleventh edition: Drs. Jean M. Nappi, Timothy J. Ives, Marcia

L. Buck, Judith L. Beizer, and Myrna Y. Munar. We sincerely thank the past editorial

team of Applied Therapeutics, with special thanks to Dr. Brian K. Alldredge and Dr.

B. Joseph Guglielmo for their guidance and support and contributions to the eleventh

edition. We would also like to thank Facts and Comparisons for allowing us to use

their data for the construction of some of our tables.

The team from Wolters Kluwer, Matt Hauber, Andrea Vosburgh, and Annette

Ferran, deserve special recognition for their efforts. Their exceptional patience,

attention to detail, and guidance have been critical to the success of this project. We

sincerely thank Tara Slagle (project management) and Samson Premkumar

(production) for their assistance in completing this edition. Most importantly, we

wish to acknowledge the love, understanding, and unwavering support of our spouses

and families. They selflessly gave to us early mornings, late nights, weekends, and

vacation time that we spent writing and editing.

Consistent with past editions, we continue to dedicate our work to our students

who inspire us and to the many patients we have been privileged to care for and who

have taught us invaluable lessons. We also dedicate the eleventh edition to those

clinicians and educators who have served as pioneering leaders and role models in

the delivery of patient-centered care using team-based approaches.