▶ Clobetasol propionate 0.05% cream, foam, ointment,
scalp application, and shampoo: very potent.
▶ Adult: Apply once daily maximum duration of
treatment 4 weeks, to be applied thinly then rinsed off
after 15 minutes; frequency of application should be
reduced after clinical improvement
l PATIENT AND CARER ADVICE Patients or carers should be
given advice on how to administer clobetasol propionate
foam, liquid (scalp application), cream, ointment and
Scalp application Patients or carers should be advised to
apply foam directly to scalp lesions (foam begins to
subside immediately on contact with skin).
l MEDICINAL FORMS There can be variation in the licensing of
different medicines containing the same drug. Forms available
from special-order manufacturers include: cream, ointment,
CAUTIONARY AND ADVISORY LABELS 28
Clobetasol propionate 500 microgram per 1 gram Etrivex
500micrograms/g shampoo | 125 ml P £9.15 DT = £9.15
CAUTIONARY AND ADVISORY LABELS 28
EXCIPIENTS: May contain Beeswax, cetostearyl alcohol (including cetyl
and stearyl alcohol), chlorocresol, propylene glycol
▶ ClobaDerm (Auden McKenzie (Pharma Division) Ltd)
Clobetasol propionate 500 microgram per 1 gram ClobaDerm
0.05% cream | 30 gram P £2.56 DT = £2.69 | 100 gram P £7.51 DT = £7.90
▶ Dermovate (GlaxoSmithKline UK Ltd)
Clobetasol propionate 500 microgram per 1 gram Dermovate
0.05% cream | 30 gram P £2.69 DT = £2.69 | 100 gram P £7.90 DT = £7.90
CAUTIONARY AND ADVISORY LABELS 28
EXCIPIENTS: May contain Propylene glycol
▶ ClobaDerm (Auden McKenzie (Pharma Division) Ltd)
Clobetasol propionate 500 microgram per 1 gram ClobaDerm
0.05% ointment | 30 gram P £2.56 DT = £2.69 | 100 gram P £7.51 DT = £7.90
▶ Dermovate (GlaxoSmithKline UK Ltd)
Clobetasol propionate 500 microgram per 1 gram Dermovate
0.05% ointment | 30 gram P £2.69 DT = £2.69 | 100 gram P £7.90 DT = £7.90
CAUTIONARY AND ADVISORY LABELS 15, 28
▶ Dermovate (GlaxoSmithKline UK Ltd)
Clobetasol propionate 500 microgram per 1 gram Dermovate
0.05% scalp application | 30 ml P £3.07 DT = £3.07 |
Combinations available: Clobetasol propionate with neomycin
Clobetasone butyrate 21-Dec-2017
Eczemas and dermatitis of all types | Maintenance
between courses of more potent corticosteroids
▶ Child: Apply 1–2 times a day, to be applied thinly
▶ Adult: Apply 1–2 times a day, to be applied thinly
▶ Clobetasone butyrate 0.05% cream and ointment:
▶ In children Licensed for use in children (age range not
l PATIENT AND CARER ADVICE Patients or carers should be
advised on the application of clobetasone butyrate
l EXCEPTIONS TO LEGAL CATEGORY Cream can be sold to the
public for short-term symptomatic treatment and control
of patches of eczema and dermatitis (but not seborrhoeic
dermatitis) in adults and children over 12 years provided
pack does not contain more than 15 g.
l MEDICINAL FORMS There can be variation in the licensing of
different medicines containing the same drug. Forms available
from special-order manufacturers include: cream, ointment
CAUTIONARY AND ADVISORY LABELS 28
Clobetasone butyrate 500 microgram per 1 gram Clobavate
0.05% ointment | 30 gram P £1.49 DT = £1.86 | 100 gram P £4.35 DT = £5.44
▶ Eumovate (GlaxoSmithKline UK Ltd)
Clobetasone butyrate 500 microgram per 1 gram Eumovate
0.05% ointment | 30 gram P £1.86 DT = £1.86 | 100 gram P £5.44 DT = £5.44
CAUTIONARY AND ADVISORY LABELS 28
EXCIPIENTS: May contain Cetostearyl alcohol (including cetyl and
stearyl alcohol), chlorocresol
▶ Eumovate (GlaxoSmithKline Consumer Healthcare, GlaxoSmithKline
Clobetasone butyrate 500 microgram per 1 gram Eumovate
0.05% cream | 30 gram P £1.86 DT = £1.86 | 100 gram P £5.44 DT = £5.44
Combinations available: Clobetasone butyrate with nystatin
Diflucortolone valerate 21-Dec-2017
Severe inflammatory skin disorders such as eczemas
unresponsive to less potent corticosteroids (using 0.3%
diflucortolone valerate)| Short-term treatment of severe
exacerbations (using 0.3% diflucortolone valerate)|
Psoriasis (using 0.3% diflucortolone valerate)
▶ Child 4–17 years: Apply 1–2 times a day for up to
2 weeks, reducing strength as condition responds, to be
applied thinly; maximum 60 g per week
▶ Adult: Apply 1–2 times a day for up to 2 weeks,
reducing strength as condition responds, to be applied
Severe inflammatory skin disorders such as eczemas
unresponsive to less potent corticosteroids (using 0.1%
diflucortolone valerate)| Psoriasis (using 0.1%
▶ Child: Apply 1–2 times a day for up to 4 weeks, to be
▶ Adult: Apply 1–2 times a day for up to 4 weeks, to be
▶ Diflucortolone valerate 0.1% cream and ointment:
▶ Diflucortolone valerate 0.3% cream and ointment: very
▶ In children Nerisone ® licensed for use in children (age range
not specified by manufacturer); Nerisone Forte ® not
licensed for use in children under 4 years.
BNF 78 Eczema and psoriasis 1245
l PRESCRIBING AND DISPENSING INFORMATION Patients or
carers should be advised on application of diflucortolone
valerate containing preparations.
l MEDICINAL FORMS There can be variation in the licensing of
different medicines containing the same drug.
CAUTIONARY AND ADVISORY LABELS 28
▶ Nerisone (Meadow Laboratories Ltd)
Diflucortolone valerate 1 mg per 1 gram Nerisone 0.1% ointment |
Diflucortolone valerate 3 mg per 1 gram Nerisone Forte 0.3%
CAUTIONARY AND ADVISORY LABELS 28
EXCIPIENTS: May contain Beeswax, cetostearyl alcohol (including cetyl
and stearyl alcohol), disodium edetate, hydroxybenzoates (parabens)
▶ Nerisone (Meadow Laboratories Ltd)
Diflucortolone valerate 1 mg per 1 gram Nerisone 0.1% cream | 30 gram P £3.98
Nerisone 0.1% oily cream | 30 gram P £4.95 DT = £4.95
Diflucortolone valerate 3 mg per 1 gram Nerisone Forte 0.3% oily
cream | 15 gram P £4.70 DT = £4.70
Inflammatory skin disorders such as eczemas
▶ Child: Apply 1–2 times a day, to be applied thinly
▶ Adult: Apply 1–2 times a day, to be applied thinly
▶ Fludroxycortide 0.0125% cream and ointment: moderate
Chronic localised recalcitrant dermatoses (but not acute
▶ Child: Cut tape to fit lesion, apply to clean, dry skin
shorn of hair, usually for 12 hours daily
▶ Adult: Cut tape to fit lesion, apply to clean, dry skin
shorn of hair, usually for 12 hours daily
▶ In children Licensed for use in children (age range not
l SIDE-EFFECTS Cushing’s syndrome . increased risk of
l PATIENT AND CARER ADVICE Patients or carers should be
counselled on application of fludroxycortide cream and
l MEDICINAL FORMS There can be variation in the licensing of
different medicines containing the same drug.
CAUTIONARY AND ADVISORY LABELS 28
EXCIPIENTS: May contain Beeswax, cetostearyl alcohol (including cetyl
and stearyl alcohol), polysorbates
▶ Fludroxycortide (Non-proprietary)
Fludroxycortide 125 microgram per 1 gram Fludroxycortide
0.0125% ointment | 60 gram P £5.99
CAUTIONARY AND ADVISORY LABELS 28
EXCIPIENTS: May contain Cetostearyl alcohol (including cetyl and
stearyl alcohol), propylene glycol
▶ Fludroxycortide (Non-proprietary)
Fludroxycortide 125 microgram per 1 gram Fludroxycortide
0.0125% cream | 60 gram P £5.99 DT = £5.99
▶ Fludroxycortide (Non-proprietary)
Fludroxycortide 4 microgram per 1 square cm Fludroxycortide
4micrograms/square cm tape 7.5cm | 20 cm P £12.49–£13.67 DT
Fluocinolone acetonide 08-Feb-2019
Severe inflammatory skin disorders such as eczemas |
▶ Child 1–17 years: Apply 1–2 times a day, to be applied
thinly, reduce strength as condition responds
▶ Adult: Apply 1–2 times a day, to be applied thinly,
reduce strength as condition responds
▶ Fluocinolone acetonide 0.025% cream, gel, and
▶ Fluocinolone acetonide 0.00625% cream and ointment:
▶ Fluocinolone acetonide 0.0025% cream: mild.
l INTERACTIONS → Appendix 1: fluocinolone
l PRESCRIBING AND DISPENSING INFORMATION Gel is useful
for application to the scalp and other hairy areas.
l PATIENT AND CARER ADVICE Patient counselling is advised
for fluocinolone acetonide cream, gel and ointment
l MEDICINAL FORMS There can be variation in the licensing of
different medicines containing the same drug.
CAUTIONARY AND ADVISORY LABELS 28
EXCIPIENTS: May contain Propylene glycol, woolfat and related
substances (including lanolin)
Fluocinolone acetonide 62.5 microgram per 1 gram Synalar 1 in 4
Dilution 0.00625% ointment | 50 gram P £4.84 DT = £4.84
Fluocinolone acetonide 250 microgram per 1 gram Synalar
0.025% ointment | 30 gram P £4.14 DT = £4.14 | 100 gram P £11.75 DT = £11.75
CAUTIONARY AND ADVISORY LABELS 28
EXCIPIENTS: May contain Benzyl alcohol, cetostearyl alcohol (including
cetyl and stearyl alcohol), polysorbates, propylene glycol
Fluocinolone acetonide 62.5 microgram per 1 gram Synalar 1 in 4
Dilution 0.00625% cream | 50 gram P £4.84 DT = £4.84
Fluocinolone acetonide 250 microgram per 1 gram Synalar
0.025% cream | 30 gram P £4.14 DT = £4.14 | 100 gram P £11.75 DT = £11.75
CAUTIONARY AND ADVISORY LABELS 28
EXCIPIENTS: May contain Hydroxybenzoates (parabens), propylene
Fluocinolone acetonide 250 microgram per 1 gram Synalar
0.025% gel | 30 gram P £5.56 DT = £5.56 | 60 gram P £10.02 DT = £10.02
Combinations available: Fluocinolone acetonide with
clioquinol, p. 1250 . Fluocinolone acetonide with neomycin,
Severe inflammatory skin disorders such as eczemas
unresponsive to less potent corticosteroids | Psoriasis
▶ Child: Apply 1–2 times a day, to be applied thinly
▶ Adult: Apply 1–2 times a day, to be applied thinly
▶ Fluocinonide 0.05% cream and ointment: potent.
▶ In children Not licensed for use in children under 1 year.
1246 Inflammatory skin conditions BNF 78
l PATIENT AND CARER ADVICE Patients or carers should be
advised on the application of fluocinonide preparations.
l MEDICINAL FORMS There can be variation in the licensing of
different medicines containing the same drug. Forms available
from special-order manufacturers include: ointment
CAUTIONARY AND ADVISORY LABELS 28
EXCIPIENTS: May contain Propylene glycol, woolfat and related
substances (including lanolin)
Fluocinonide 500 microgram per 1 gram Metosyn 0.05% ointment
| 25 gram P £3.50 DT = £3.50 | 100 gram P £13.15 DT =
CAUTIONARY AND ADVISORY LABELS 28
EXCIPIENTS: May contain Propylene glycol
▶ Metosyn FAPG (Reig Jofre UK Ltd)
Fluocinonide 500 microgram per 1 gram Metosyn FAPG 0.05%
cream | 25 gram P £3.96 DT = £3.96 | 100 gram P £13.34 DT
Severe inflammatory skin disorders such as dermatitis
and eczemas unresponsive to less potent corticosteroids
▶ Child 3 months–17 years: Apply 1–2 times a day, to be
▶ Adult: Apply 1–2 times a day, to be applied thinly
▶ Fluticasone cream 0.05%: potent.
▶ Fluticasone ointment 0.005%: potent.
l INTERACTIONS → Appendix 1: corticosteroids
l PATIENT AND CARER ADVICE Patients or carers should be
given advice on application of fluticasone creams and
l MEDICINAL FORMS There can be variation in the licensing of
different medicines containing the same drug.
CAUTIONARY AND ADVISORY LABELS 28
EXCIPIENTS: May contain Cetostearyl alcohol (including cetyl and
stearyl alcohol), imidurea, propylene glycol
▶ Fluticasone (Non-proprietary)
Fluticasone propionate 500 microgram per 1 gram Fluticasone
0.05% cream | 30 gram P £4.24 DT = £4.24
▶ Cutivate (GlaxoSmithKline UK Ltd)
Fluticasone propionate 500 microgram per 1 gram Cutivate
0.05% cream | 15 gram P £2.27 DT = £2.27 | 30 gram P £4.24 DT = £4.24
CAUTIONARY AND ADVISORY LABELS 28
EXCIPIENTS: May contain Propylene glycol
▶ Cutivate (GlaxoSmithKline UK Ltd)
Fluticasone propionate 50 microgram per 1 gram Cutivate 0.005%
ointment | 15 gram P £2.27 DT = £2.27 | 30 gram P £4.24 DT
l DRUG ACTION Hydrocortisone has equal glucocorticoid
and mineralocorticoid activity.
Mild inflammatory skin disorders such as eczemas
▶ Child: Apply 1–2 times a day, to be applied thinly
▶ Adult: Apply 1–2 times a day, to be applied thinly
▶ Child: Apply 1–2 times a day for no longer than 1 week,
discontinued as soon as the inflammation subsides
▶ Hydrocortisone cream and ointment 0.5 to 2.5%: mild
l INTERACTIONS → Appendix 1: corticosteroids
l PRESCRIBING AND DISPENSING INFORMATION When
hydrocortisone cream or ointment is prescribed and no
strength is stated, the 1% strength should be supplied.
Although Dioderm® contains only 0.1% hydrocortisone,
the formulation is designed to provide a clinical activity
comparable to that of Hydrocortisone Cream 1% BP.
l PATIENT AND CARER ADVICE Patient counselling is advised
for hydrocortisone cream and ointment (application).
l PROFESSION SPECIFIC INFORMATION
Dental practitioners’ formulary
Hydrocortisone Cream 1% 15 g may be prescribed.
l EXCEPTIONS TO LEGAL CATEGORY
Over-the-counter hydrocortisone preparations Skin creams and
ointments containing hydrocortisone (alone or with other
ingredients) can be sold to the public for the treatment of
allergic contact dermatitis, irritant dermatitis, insect bite
reactions and mild to moderate eczema in patients over
10 years, to be applied sparingly over the affected area
1–2 times daily for max. 1 week. Over-the-counter
hydrocortisone preparations should not be sold without
medical advice for children under 10 years or for pregnant
women; they should not be sold for application to the
face, anogenital region, broken or infected skin (including
cold sores, acne, and athlete’s foot).
l MEDICINAL FORMS There can be variation in the licensing of
different medicines containing the same drug. Forms available
from special-order manufacturers include: cream, ointment
CAUTIONARY AND ADVISORY LABELS 28
EXCIPIENTS: May contain Benzyl alcohol, cetostearyl alcohol (including
cetyl and stearyl alcohol), hydroxybenzoates (parabens), propylene glycol
▶ Hydrocortisone (Non-proprietary)
▶ Dioderm (Dermal Laboratories Ltd)
Hydrocortisone 1 mg per 1 gram Dioderm 0.1% cream | 30 gram P £2.39 DT = £2.39
▶ Mildison Lipocream (LEO Pharma)
Hydrocortisone 10 mg per 1 gram Mildison Lipocream 1% cream | 30 gram P £1.71 DT = £1.88
CAUTIONARY AND ADVISORY LABELS 28
▶ Hydrocortisone (Non-proprietary)
Hydrocortisone 25 mg per 1 gram Hydrocortisone 2.5% ointment |
15 gram P £44.00 DT = £24.57 | 30 gram P £49.14–£88.00
Combinations available: Hydrocortisone with benzalkonium
chloride, dimeticone and nystatin, p. 1251 . Hydrocortisone
with fusidic acid, p. 1252 . Hydrocortisone with miconazole,
p. 1252 . Hydrocortisone with oxytetracycline, p. 1252
BNF 78 Eczema and psoriasis 1247
Hydrocortisone butyrate 21-Dec-2017
Severe inflammatory skin disorders such as eczemas
unresponsive to less potent corticosteroids | Psoriasis
▶ Child 1–17 years: Apply 1–2 times a day, to be applied
▶ Adult: Apply 1–2 times a day, to be applied thinly
▶ Hydrocortisone butyrate 0.1% cream, liquid, and
l PATIENT AND CARER ADVICE Patients or carers should be
given advice on how to administer hydrocortisone butyrate
lotion, cream, ointment and scalp lotion.
Medicines for Children leaflet: Hydrocortisone (topical) for eczema
www.medicinesforchildren.org.uk/hydrocortisone-topicaleczema
l MEDICINAL FORMS There can be variation in the licensing of
different medicines containing the same drug. Forms available
from special-order manufacturers include: ointment
CAUTIONARY AND ADVISORY LABELS 28
CAUTIONARY AND ADVISORY LABELS 28
EXCIPIENTS: May contain Benzyl alcohol, cetostearyl alcohol (including
cetyl and stearyl alcohol), hydroxybenzoates (parabens)
▶ Locoid Lipocream (LEO Pharma)
Hydrocortisone butyrate 1 mg per 1 gram Locoid 0.1% Lipocream
| 30 gram P £1.69 DT = £1.60 | 100 gram P £5.17 DT = £4.93
CAUTIONARY AND ADVISORY LABELS 15(excluding Locoid Crelo
EXCIPIENTS: May contain Butylated hydroxytoluene, cetostearyl alcohol
(including cetyl and stearyl alcohol), hydroxybenzoates (parabens),
Hydrocortisone butyrate 1 mg per 1 ml Locoid 0.1% scalp lotion | 100 ml P £6.83 DT = £6.83
Hydrocortisone butyrate 1 mg per 1 gram Locoid Crelo 0.1%
topical emulsion | 100 gram P £5.91
Mometasone furoate 21-Dec-2017
Severe inflammatory skin disorders such as eczemas
unresponsive to less potent corticosteroids | Psoriasis
▶ Child 2–17 years: Apply once daily, to be applied thinly
▶ Adult: Apply once daily, to be applied thinly (to scalp in
▶ Mometasone furoate 0.1% cream, ointment, and scalp
l INTERACTIONS → Appendix 1: corticosteroids
l MEDICINAL FORMS There can be variation in the licensing of
different medicines containing the same drug. Forms available
from special-order manufacturers include: ointment
CAUTIONARY AND ADVISORY LABELS 28
EXCIPIENTS: May contain Beeswax
▶ Mometasone furoate (Non-proprietary)
▶ Elocon (Merck Sharp & Dohme Ltd)
CAUTIONARY AND ADVISORY LABELS 28
EXCIPIENTS: May contain Beeswax, propylene glycol
▶ Mometasone furoate (Non-proprietary)
Mometasone furoate 1 mg per 1 gram Mometasone 0.1% ointment
| 15 gram P £4.32 | 30 gram P £5.19 DT = £3.40 | 50 gram P £12.44 | 100 gram P £12.82 DT = £11.33
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