▶ Grapefruit juice increases the exposure to propafenone.
Monitor and adjust dose.oStudy
▶ Dronedarone is predicted to increase the concentration of
guanfacine. Adjust guanfacine dose, p. 352.oTheoretical
▶ H2 receptor antagonists (cimetidine) increase the exposure to
▶ H2 receptor antagonists (cimetidine) slightly increase the
exposure to flecainide. Monitor and adjust dose.nStudy
▶ H2 receptor antagonists (cimetidine) increase the exposure to
lidocaine. Monitor and adjust dose.oStudy
▶ H2 receptor antagonists (cimetidine) are predicted to increase
propafenone. Monitor and adjust dose.
▶ HIV-protease inhibitors are predicted to increase the exposure
to amiodarone. Avoid.rTheoretical → Also see TABLE 9
▶ HIV-protease inhibitors are predicted to increase the exposure
to disopyramide.rTheoretical → Also see TABLE 9 p. 1377
▶ HIV-protease inhibitors very markedly increase the exposure to
dronedarone. Avoid.rStudy → Also see TABLE 9 p. 1377
▶ HIV-protease inhibitors (ritonavir) are predicted to increase the
flecainide. Avoid or monitor side effects.r
▶ HIV-protease inhibitors are predicted to increase the exposure
▶ HIV-protease inhibitors are predicted to increase the exposure
to propafenone. Monitor and adjust dose.rStudy
▶ Amiodarone is predicted to increase the exposure to ibrutinib.
Adjust ibrutinib dose, p. 983.rTheoretical
▶ Dronedarone is predicted to increase the exposure to ibrutinib.
Adjust ibrutinib dose with moderate inhibitors of CYP3A4,
▶ Idelalisib is predicted to increase the exposure to amiodarone.
▶ Idelalisib very markedly increases the exposure to
▶ Idelalisib is predicted to increase the exposure to propafenone.
Monitor and adjust dose.rStudy
is predicted to increase the exposure to dronedarone.
▶ Imatinib is predicted to increase the exposure to propafenone.
Monitor and adjust dose.oStudy
▶ Dronedarone is predicted to increase the exposure to
ivabradine. Adjust ivabradine dose, p. 211.rTheoretical
▶ Dronedarone is predicted to increase the exposure to ivacaftor.
Adjust ivacaftor p. 293 or tezacaftor with ivacaftor p. 295 dose
with moderate inhibitors of CYP3A4.rStudy
is predicted to increase the exposure to lapatinib.
Study → Also see TABLE 9 p. 1377
▶ Ledipasvir increases the risk of severe bradycardia or heart
block when given with amiodarone. Refer to specialist
▶ Letermovir is predicted to increase the concentration of
▶ Amiodarone is predicted to increase the exposure to
. Separate administration by 12 hours.o ▶ Dronedarone is predicted to increase the exposure to
lomitapide. Avoid.oTheoretical
▶ Dronedarone is predicted to increase the exposure to
▶ Dronedarone is predicted to increase the exposure to
lurasidone. Adjust lurasidone dose, p. 398.oStudy
▶ Macrolides (clarithromycin) very markedly increase the
exposure to dronedarone. Avoid.rStudy → Also see TABLE 9
▶ Macrolides (clarithromycin) are predicted to increase the
propafenone. Monitor and adjust dose.r
▶ Macrolides (clarithromycin, erythromycin) are predicted to
increase the exposure to lidocaine.oTheoretical
▶ Macrolides (erythromycin) are predicted to moderately increase
the exposure to dronedarone. Avoid.rTheoretical → Also
▶ Macrolides (erythromycin) are predicted to increase the
with antiarrhythmics. Avoid.rTheoretical
▶ Dronedarone is predicted to increase the exposure to
midazolam. Monitor side effects and adjust dose.rStudy
▶ Dronedarone is predicted to increase the exposure to
▶ Mitotane is predicted to decrease the exposure to
(disopyramide, dronedarone). Avoid.r
is predicted to decrease the efficacy of propafenone.
▶ Dronedarone increases the risk of neutropenia when given
with monoclonal antibodies (brentuximab vedotin). Monitor and
▶ Dronedarone is predicted to increase the exposure to
. Adjust naloxegol dose and monitor side effects, p. 65.
▶ Netupitant is predicted to increase the exposure to
propafenone. Monitor and adjust dose.oStudy
▶ Nevirapine is predicted to decrease the exposure to
▶ Nilotinib is predicted to increase the exposure to propafenone.
Monitor and adjust dose.oStudy
▶ Antiarrhythmics (amiodarone, dronedarone) are predicted to
increase the exposure to nintedanib.oStudy
▶ NSAIDs (celecoxib) are predicted to increase the exposure to
antiarrhythmics (flecainide, propafenone). Monitor and adjust
▶ Dronedarone is predicted to increase the exposure to olaparib.
Avoid moderate inhibitors of CYP3A4 or adjust olaparib dose,
▶ Dronedarone is predicted to increase the exposure to opioids
(alfentanil, buprenorphine, fentanyl, oxycodone). Monitor and
▶ Amiodarone is predicted to increase the concentration of
opioids (fentanyl).oTheoretical → Also see TABLE 6 p. 1376
▶ Dronedarone is predicted to increase the exposure to opioids
(methadone, sufentanil).oTheoretical → Also see TABLE 9
▶ Dronedarone is predicted to increase the exposure to
▶ Antiarrhythmics (amiodarone, dronedarone) are predicted to
Theoretical → Also see TABLE 9
. Adjust dose.o ▶ Dronedarone is predicted to increase the exposure to
pazopanib.oTheoretical → Also see TABLE 9 p. 1377
▶ Propafenone is predicted to increase the anticoagulant effect
of phenindione. Monitor and adjust dose.oTheoretical
▶ Dronedarone is predicted to increase the exposure to
phosphodiesterase type-5 inhibitors (avanafil). Adjust avanafil
▶ Dronedarone is predicted to increase the exposure to
phosphodiesterase type-5 inhibitors (sildenafil). Monitor or
adjust sildenafil dose with moderate inhibitors of CYP3A4,
p. 813.oStudy → Also see TABLE 9 p. 1377
▶ Dronedarone is predicted to increase the exposure to
phosphodiesterase type-5 inhibitors (tadalafil).rTheoretical
▶ Dronedarone is predicted to increase the exposure to
phosphodiesterase type-5 inhibitors
Theoretical → Also see TABLE 9 p. 1377
▶ Amiodarone is predicted to increase the exposure to
▶ Dronedarone potentially increases the exposure to
▶ Dronedarone is predicted to increase the exposure to pimozide.
Avoid.rTheoretical → Also see TABLE 9 p. 1377
▶ Dronedarone is predicted to increase the exposure to
▶ Quinolones (ciprofloxacin) slightly increase the exposure to
▶ Dronedarone is predicted to increase the exposure to
ranolazine.rStudy → Also see TABLE 9 p. 1377
BNF 78 Antiarrhythmics — Antiarrhythmics 1389
▶ Amiodarone is predicted to increase the exposure to retinoids
amiodarone. Avoid.oTheoretical → Also see TABLE 9
▶ Dronedarone is predicted to increase the exposure to
ribociclib.oStudy → Also see TABLE 9 p. 1377
▶ Rifampicin is predicted to decrease the exposure to
(disopyramide, dronedarone). Avoid.r
is predicted to decrease the efficacy of propafenone.
▶ Dronedarone is predicted to increase the exposure to
rivaroxaban. Avoid.oTheoretical
▶ Rolapitant is predicted to increase the exposure to
▶ Dronedarone is predicted to increase the exposure to
▶ Dronedarone is predicted to increase the exposure to
▶ Amiodarone is predicted to increase the concentration of
▶ Dronedarone increases the concentration of sirolimus. Monitor
▶ Sofosbuvir is predicted to increase the risk of severe
bradycardia or heart block when given with amiodarone. Refer
to specialist literature.rAnecdotal
▶ SSRIs (fluvoxamine) are predicted to increase the exposure to
propafenone. Monitor and adjust dose.oStudy
▶ Dronedarone is predicted to increase the exposure to SSRIs
(citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine,
sertraline).rTheoretical → Also see TABLE 9 p. 1377
▶ Dronedarone is predicted to increase the exposure to SSRIs
(dapoxetine). Adjust dapoxetine dose with moderate inhibitors
of CYP3A4, p. 821.oTheoretical
▶ St John’s Wort is predicted to decrease the exposure to
dronedarone. Avoid.rTheoretical
▶ Amiodarone is predicted to increase the risk of rhabdomyolysis
when given with statins (atorvastatin). Monitor and adjust
▶ Dronedarone is predicted to increase the exposure to statins
(atorvastatin). Monitor and adjust dose.rStudy
▶ Amiodarone is predicted to increase the exposure to statins
▶ Dronedarone slightly increases the exposure to statins
(rosuvastatin). Adjust dose.rStudy
▶ Amiodarone increases the risk of rhabdomyolysis when given
statins (simvastatin). Adjust simvastatin dose, p. 205.
▶ Dronedarone is predicted to increase the exposure to statins
(simvastatin). Use with caution and adjust simvastatin dose,
▶ Amiodarone is predicted to increase the exposure to
. Use with caution and adjust dose.o ▶ Dronedarone
is predicted to increase the exposure to sunitinib.
Theoretical → Also see TABLE 9 p. 1377
▶ Lidocaine is predicted to increase the effects of
▶ Amiodarone is predicted to increase the concentration of
▶ Dronedarone is predicted to increase the concentration of
▶ Dronedarone is predicted to increase the exposure to taxanes
▶ Dronedarone is predicted to increase the exposure to taxanes
▶ Dronedarone is predicted to increase the concentration of
▶ Dronedarone is predicted to increase the exposure to
tezacaftor. Adjust tezacaftor with ivacaftor p. 295 dose with
moderate inhibitors of CYP3A4.rStudy
▶ Theophylline decreases the efficacy of adenosine. Separate
administration by 24 hours.nStudy
▶ Amiodarone is predicted to increase the risk of thyroid
▶ Amiodarone is predicted to increase the exposure to ticagrelor.
Use with caution or avoid.rStudy
▶ Dronedarone given with a potent CYP2C19 inhibitor is
predicted to increase the exposure to tofacitinib. Adjust
tofacitinib dose, p. 1105.oStudy
▶ Dronedarone is predicted to increase the exposure to
tolterodine.nTheoretical → Also see TABLE 9 p. 1377
▶ Dronedarone is predicted to increase the exposure to
tolvaptan. Manufacturer advises caution or adjust tolvaptan
dose with moderate inhibitors of CYP3A4,
p. 669.o ▶ Antiarrhythmics (amiodarone, dronedarone) are predicted to
increase the exposure to topotecan.rStudy
▶ Antiarrhythmics (amiodarone, dronedarone) are predicted to
increase the concentration of trametinib.oTheoretical
▶ Dronedarone is predicted to increase the exposure to
▶ Dronedarone is predicted to increase the exposure to tricyclic
antidepressants. Avoid.rTheoretical → Also see TABLE 9
▶ Propafenone is predicted to increase the concentration of
tricyclic antidepressants.oTheoretical → Also see TABLE 10
▶ Dronedarone is predicted to increase the exposure to ulipristal.
Avoid if used for uterine fibroids.oStudy
▶ Amiodarone is predicted to increase the concentration of
velpatasvir. Avoid or monitor.oTheoretical
▶ Amiodarone is predicted to increase the exposure to
venetoclax. Avoid or monitor for toxicity.rTheoretical
▶ Dronedarone is predicted to increase the exposure to
. Avoid or adjust dose—consult product literature.
▶ Dronedarone is predicted to increase the exposure to vinca
alkaloids.rTheoretical → Also see TABLE 9 p. 1377
▶ Dronedarone is predicted to increase the exposure to
Anticholinesterases, centrally acting → see TABLE 6 p. 1376
anticholinesterases, centrally acting
.o ▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone) are predicted to decrease the exposure
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the exposure to galantamine. Monitor
▶ Anticholinesterases, centrally acting are predicted to increase
▶ Anticholinesterases, centrally acting are predicted to increase
the risk of bradycardia when given with beta blockers,
selective.oAnecdotal → Also see TABLE 6 p. 1376
▶ Bupropion is predicted to increase the exposure to
galantamine. Monitor and adjust dose.oStudy
▶ Calcium channel blockers (diltiazem, verapamil) increase the risk
of bradycardia when given with anticholinesterases, centrally
acting.oAnecdotal → Also see TABLE 6 p. 1376
▶ Cinacalcet is predicted to increase the exposure to
galantamine. Monitor and adjust dose.oStudy
▶ Cobicistat is predicted to increase the exposure to
galantamine. Monitor and adjust dose.oStudy
▶ Enzalutamide is predicted to decrease the exposure to
▶ HIV-protease inhibitors are predicted to increase the exposure
to galantamine. Monitor and adjust dose.oStudy
▶ Idelalisib is predicted to increase the exposure to galantamine.
Monitor and adjust dose.oStudy
1390 Antiarrhythmics — Anticholinesterases, centrally acting BNF 78
▶ Macrolides (clarithromycin) are predicted to increase the
▶ Anticholinesterases, centrally acting are predicted to decrease
neuromuscular blocking drugs, non-depolarising.
Theoretical → Also see TABLE 6 p. 1376
▶ Rifampicin is predicted to decrease the exposure to donepezil.
▶ SSRIs (fluoxetine, paroxetine) are predicted to increase the
▶ Terbinafine is predicted to increase the exposure to
galantamine. Monitor and adjust dose.oStudy
Antiepileptics → see TABLE 1 p. 1375 (hepatotoxicity), TABLE 18 p. 1379
(hyponatraemia), TABLE 15 p. 1378 (myelosuppression), TABLE 12 p. 1378
(peripheral neuropathy), TABLE 11 p. 1377 (CNS depressant effects)
FOOD AND LIFESTYLE Avoid taking milk, dairy products,
carbonated drinks, fruit juices, or caffeine-containing food
and drinks at the same time as stiripentol.
▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone) are predicted to decrease the exposure
▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone) are predicted to markedly decrease the
exposure to abemaciclib. Avoid.rStudy
▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone) are predicted to decrease the exposure
▶ Acetazolamide potentially increases the risk of toxicity when
▶ Acetazolamide potentially increases the risk of overheating
and dehydration when given with zonisamide. Avoid in
▶ Carbamazepine is predicted to decrease the exposure to
▶ Antiepileptics (fosphenytoin, phenytoin) are predicted to
decrease the exposure to agomelatine.oTheoretical
▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone) decrease the concentration of
▶ Alcohol (beverage) potentially increases the risk of visual
disturbances when given with retigabine.oStudy
▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone) are predicted to decrease the exposure
decreases the exposure to aliskiren.o ▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone) are predicted to decrease the exposure
to alprazolam. Adjust dose.oTheoretical → Also see
▶ Fosphenytoin is predicted to decrease the exposure to
aminophylline. Adjust dose.oStudy
▶ Phenobarbital is predicted to decrease the exposure to
aminophylline. Adjust dose.oTheoretical
▶ Phenytoin decreases the exposure to aminophylline. Adjust
▶ Primidone is predicted to increase the clearance of
aminophylline. Adjust dose.oTheoretical
▶ Stiripentol is predicted to increase the exposure to
aminophylline. Avoid.oTheoretical
▶ Antiepileptics (fosphenytoin, phenobarbital, phenytoin,
primidone) are predicted to increase the risk of
methaemoglobinaemia when given with topical anaesthetics,
▶ Phenytoin is predicted to decrease the exposure to
anaesthetics, local (ropivacaine).oTheoretical
▶ Antacids decrease the absorption of gabapentin. Gabapentin
should be taken 2 hours after antacids.oStudy
▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone) are predicted to decrease the exposure
antiarrhythmics (disopyramide, dronedarone). Avoid.r
▶ Antiarrhythmics (amiodarone) are predicted to slightly increase
the concentration of antiepileptics (fosphenytoin, phenytoin).
Monitor and adjust dose.rStudy → Also see TABLE 12 p. 1378
▶ Antiepileptics (fosphenytoin, phenytoin) are predicted to
▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone) are predicted to decrease the efficacy of
antiarrhythmics (propafenone).oStudy
▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone) are predicted to decrease the exposure
to anticholinesterases, centrally acting (donepezil).nStudy
▶ Antiepileptics (carbamazepine) decrease the concentration of
antiepileptics (brivaracetam).oStudy
▶ Antiepileptics (fosphenytoin, phenytoin) decrease the
concentration of antiepileptics (brivaracetam).oStudy
▶ Antiepileptics (lamotrigine) potentially increase the
concentration of antiepileptics (carbamazepine) and
antiepileptics (carbamazepine) decrease the concentration of
antiepileptics (lamotrigine). Adjust lamotrigine dose and
antiepileptics (carbamazepine) and antiepileptics
(carbamazepine) increase the concentration of antiepileptics
(phenobarbital). Adjust dose.oStudy
▶ Antiepileptics (topiramate) increase the risk of carbamazepine
antiepileptics (carbamazepine).
▶ Antiepileptics (stiripentol) increase the concentration of
antiepileptics (carbamazepine, phenobarbital). Avoid in Dravet
▶ Antiepileptics (carbamazepine) slightly decrease the exposure
to antiepileptics (eslicarbazepine, oxcarbazepine). Monitor and
▶ Antiepileptics (oxcarbazepine) are predicted to increase the
concentration of antiepileptics (fosphenytoin). Monitor
concentration and adjust dose.oStudy
▶ Antiepileptics (stiripentol) are predicted to increase the
concentration of antiepileptics (fosphenytoin).rStudy
▶ Antiepileptics (carbamazepine) affect the concentration of
antiepileptics (fosphenytoin, phenytoin) and antiepileptics
(fosphenytoin, phenytoin) decrease the concentration of
(carbamazepine). Monitor and adjust dose.r
▶ Antiepileptics (eslicarbazepine) increase the exposure to
antiepileptics (fosphenytoin, phenytoin) and antiepileptics
(fosphenytoin, phenytoin) decrease the exposure to
(eslicarbazepine). Monitor and adjust dose.
▶ Antiepileptics (valproate) affect the concentration of
antiepileptics (fosphenytoin, phenytoin) and antiepileptics
(fosphenytoin, phenytoin) decrease the concentration of
antiepileptics (valproate).rStudy
▶ Antiepileptics (vigabatrin) decrease the concentration of
antiepileptics (fosphenytoin, phenytoin).nStudy
▶ Antiepileptics (fosphenytoin) decrease the concentration of
antiepileptics (lamotrigine). Monitor and adjust lamotrigine
▶ Antiepileptics (phenobarbital, phenytoin, primidone) decrease
the concentration of antiepileptics (lamotrigine). Monitor and
adjust lamotrigine dose, p. 318.oStudy → Also see
BNF 78 Anticholinesterases, centrally acting — Antiepileptics 1391
▶ Antiepileptics (valproate) increase the exposure to antiepileptics
. Adjust lamotrigine dose and monitor rash, p. 318.
▶ Antiepileptics (lamotrigine) are predicted to increase the
concentration of antiepileptics (oxcarbazepine) and
antiepileptics (oxcarbazepine) are predicted to decrease the
concentration of antiepileptics (lamotrigine). Monitor side
effects and adjust dose.oStudy
▶ Antiepileptics (carbamazepine, fosphenytoin) are predicted to
decrease the exposure to antiepileptics (perampanel). Monitor
▶ Antiepileptics (oxcarbazepine) decrease the concentration of
antiepileptics (perampanel) and antiepileptics (perampanel)
increase the concentration of antiepileptics (oxcarbazepine).
Monitor and adjust dose.oStudy
▶ Antiepileptics (phenobarbital, phenytoin, primidone) are
predicted to decrease the exposure to antiepileptics
(perampanel). Monitor and adjust dose.oStudy → Also
▶ Antiepileptics (phenytoin) increase the concentration of
antiepileptics (phenobarbital) and antiepileptics (phenobarbital)
antiepileptics (phenytoin).o ▶ Antiepileptics (fosphenytoin) increase the concentration of
antiepileptics (phenobarbital, primidone) and antiepileptics
(phenobarbital, primidone) affect the concentration of
antiepileptics (fosphenytoin).oStudy
▶ Antiepileptics (oxcarbazepine) are predicted to increase the
concentration of antiepileptics (phenytoin). Monitor
concentration and adjust dose.oStudy
▶ Antiepileptics (stiripentol) are predicted to increase the
concentration of antiepileptics (phenytoin). Avoid in Dravet
▶ Antiepileptics (carbamazepine) potentially decrease the
concentration of antiepileptics (primidone) and antiepileptics
(primidone) potentially decrease the concentration of
antiepileptics (carbamazepine). Adjust dose.oAnecdotal
▶ Antiepileptics (phenytoin) increase the concentration of
antiepileptics (primidone) and antiepileptics (primidone) affect
the concentration of antiepileptics (phenytoin).oStudy
▶ Antiepileptics (stiripentol) are predicted to increase the
concentration of antiepileptics (primidone).rTheoretical
▶ Antiepileptics (valproate) affect the concentration of
(primidone). Monitor and adjust dose.r
▶ Antiepileptics (carbamazepine) slightly increase the clearance
of antiepileptics (retigabine).oStudy
▶ Antiepileptics (fosphenytoin, phenytoin) are predicted to slightly
antiepileptics (retigabine).o ▶ Antiepileptics (valproate) increase the exposure to antiepileptics
(rufinamide). Adjust rufinamide dose, p. 326.oStudy
▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone) decrease the exposure to antiepileptics
concentration of antiepileptics (topiramate) and antiepileptics
(topiramate) increase the concentration of antiepileptics
. Monitor and adjust dose.o ▶ Antiepileptics (phenobarbital, primidone) are predicted to
decrease the concentration of antiepileptics (topiramate).n
▶ Antiepileptics (phenobarbital) decrease the concentration of
antiepileptics (valproate) and antiepileptics (valproate) increase
the concentration of antiepileptics (phenobarbital). Monitor
▶ Antiepileptics (topiramate) increase the risk of toxicity when
given with antiepileptics (valproate).rStudy
▶ Antiepileptics (carbamazepine) slightly to moderately decrease
the concentration of antiepileptics (zonisamide) and
antiepileptics (zonisamide) affect the concentration of
antiepileptics (carbamazepine). Monitor and adjust dose.
▶ Antiepileptics (fosphenytoin, phenytoin) slightly to moderately
decrease the concentration of antiepileptics (zonisamide).
Monitor and adjust dose.oStudy
▶ Antiepileptics (phenobarbital, primidone) are predicted to
decrease the concentration of antiepileptics (zonisamide).
Monitor and adjust dose.oStudy
▶ Antiepileptics (topiramate) potentially increase the risk of
overheating and dehydration when given with antiepileptics
(zonisamide). Avoid in children.rTheoretical
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to very slightly increase the exposure to
▶ Antifungals, azoles (miconazole) increase the risk of
carbamazepine toxicity when given with carbamazepine.
Monitor and adjust dose.rAnecdotal
▶ Antifungals, azoles (miconazole) increase the risk of phenytoin
toxicity when given with fosphenytoin. Monitor and adjust
▶ Antifungals, azoles (miconazole) increase the risk of phenytoin
phenytoin. Monitor and adjust dose.
▶ Carbamazepine is predicted to decrease the efficacy of
antifungals, azoles (fluconazole) and antifungals, azoles
(fluconazole) increase the concentration of carbamazepine.
Avoid or monitor carbamazepine concentration and adjust
dose accordingly, p. 311.rTheoretical → Also see TABLE 1
▶ Antifungals, azoles (fluconazole) increase the concentration of
antiepileptics (fosphenytoin, phenytoin). Monitor concentration
▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone) are predicted to decrease the exposure
to antifungals, azoles (isavuconazole). Avoid.rStudy
▶ Fosphenytoin very markedly decreases the exposure to
antifungals, azoles (itraconazole). Avoid and for 14 days after
▶ Phenobarbital decreases the concentration of antifungals,
azoles (itraconazole). Avoid and for 14 days after stopping
▶ Phenytoin very markedly decreases the exposure to antifungals,
azoles (itraconazole). Avoid and for 14 days after stopping
▶ Primidone is predicted to decrease the concentration of
antifungals, azoles (itraconazole).oTheoretical
▶ Carbamazepine is predicted to decrease the efficacy of
antifungals, azoles (itraconazole, voriconazole) and antifungals,
azoles (itraconazole, voriconazole) increase the concentration
of carbamazepine. Avoid or adjust dose.oTheoretical →
▶ Carbamazepine is predicted to decrease the efficacy of
antifungals, azoles (ketoconazole) and antifungals, azoles
(ketoconazole) slightly increase the concentration of
carbamazepine. Avoid or monitor carbamazepine
concentration and adjust dose accordingly,
p. 311.o ▶ Phenobarbital is predicted to decrease the concentration of
antifungals, azoles (ketoconazole). Avoid.oStudy
▶ Antiepileptics (fosphenytoin, phenytoin) decrease the exposure
to antifungals, azoles (ketoconazole). Avoid.oStudy
▶ Primidone is predicted to decrease the concentration of
antifungals, azoles (ketoconazole, posaconazole). Avoid.
▶ Carbamazepine is predicted to decrease the efficacy of
antifungals, azoles (posaconazole) and antifungals, azoles
(posaconazole) increase the concentration of carbamazepine.
▶ Phenobarbital is predicted to decrease the concentration of
antifungals, azoles (posaconazole). Avoid.oStudy
▶ Antiepileptics (fosphenytoin, phenytoin) are predicted to
decrease the exposure to antifungals, azoles (posaconazole).
▶ Fosphenytoin decreases the exposure to antifungals, azoles
(voriconazole) and antifungals, azoles (voriconazole) increase
1392 Antiepileptics — Antiepileptics BNF 78
the exposure to fosphenytoin. Avoid or adjust voriconazole
dose and monitor phenytoin concentration,
p. 599.o ▶ Phenytoin decreases the exposure to antifungals, azoles
(voriconazole) and antifungals, azoles (voriconazole) increase
the exposure to phenytoin. Avoid or adjust voriconazole dose
decrease the concentration of antifungals, azoles (voriconazole).
▶ Antihistamines, sedating (hydroxyzine) potentially increase the
risk of overheating and dehydration when given with
zonisamide. Avoid in children.rTheoretical
▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone) are predicted to decrease the exposure
Comments
Post a Comment
اكتب تعليق حول الموضوع