▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone) are predicted to very markedly decrease
the exposure to bosutinib. Avoid.rStudy
▶ Antifungals, azoles (fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure to bosutinib. Avoid or
adjust dose.rTheoretical → Also see TABLE 9 p. 1377
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to markedly increase the exposure to bosutinib.
Avoid or adjust dose.rStudy → Also see TABLE 9 p. 1377
▶ Apalutamide is predicted to decrease the exposure to
bosutinib. Avoid or monitor.oStudy → Also see TABLE 9
▶ Aprepitant is predicted to increase the exposure to bosutinib.
Avoid or adjust dose.rTheoretical
▶ Bosentan is predicted to decrease the exposure to bosutinib.
▶ Calcium channel blockers (diltiazem, verapamil) are predicted to
bosutinib. Avoid or adjust dose.
▶ Cobicistat is predicted to markedly increase the exposure to
bosutinib. Avoid or adjust dose.rStudy
▶ Bosutinib is predicted to increase the risk of bleeding events
when given with coumarins.rTheoretical
▶ Crizotinib is predicted to increase the exposure to bosutinib.
Avoid or adjust dose.rTheoretical → Also see TABLE 15
p. 1378 → Also see TABLE 9 p. 1377
▶ Efavirenz is predicted to decrease the exposure to bosutinib.
Avoid.rTheoretical → Also see TABLE 9 p. 1377
▶ Enzalutamide is predicted to very markedly decrease the
exposure to bosutinib. Avoid.rStudy
▶ Etravirine is predicted to decrease the exposure to bosutinib.
▶ Fosaprepitant is predicted to increase the exposure to
▶ Grapefruit juice is predicted to increase the exposure to
▶ H2 receptor antagonists are predicted to decrease the
absorption of bosutinib.oTheoretical
▶ HIV-protease inhibitors are predicted to markedly increase the
exposure to bosutinib. Avoid or adjust dose.rStudy →
▶ Idelalisib is predicted to markedly increase the exposure to
bosutinib. Avoid or adjust dose.rStudy → Also see TABLE 15
▶ Imatinib is predicted to increase the exposure to bosutinib.
Avoid or adjust dose.rTheoretical → Also see TABLE 15
▶ Macrolides (clarithromycin) are predicted to markedly increase
the exposure to bosutinib. Avoid or adjust dose.rStudy →
▶ Macrolides (erythromycin) are predicted to increase the
▶ Mitotane is predicted to very markedly decrease the exposure
to bosutinib. Avoid.rStudy → Also see TABLE 15 p. 1378
▶ Modafinil is predicted to decrease the exposure to bosutinib.
▶ Netupitant is predicted to increase the exposure to bosutinib.
Avoid or adjust dose.rTheoretical
▶ Nevirapine is predicted to decrease the exposure to bosutinib.
▶ Nilotinib is predicted to increase the exposure to bosutinib.
Avoid or adjust dose.rTheoretical → Also see TABLE 15
p. 1378 → Also see TABLE 9 p. 1377
▶ Bosutinib is predicted to increase the risk of bleeding events
when given with phenindione.rTheoretical
▶ Pitolisant is predicted to decrease the exposure to bosutinib.
▶ Proton pump inhibitors are predicted to decrease the
absorption of bosutinib.oStudy
▶ Rifampicin is predicted to very markedly decrease the
exposure to bosutinib. Avoid.rStudy
▶ St John’s Wort is predicted to decrease the exposure to
Botulinum toxin type A → see TABLE 20 p. 1379 (neuromuscular
Botulinum toxin type B → see TABLE 20 p. 1379 (neuromuscular
SEPARATION OF ADMINISTRATION Other oral drugs should not be
taken 1 hour before, or after, administration of bowel
cleansing preparations because absorption may be impaired.
Consider withholding ACE inhibitors, angiotensin-II receptor
antagonists, and NSAIDs on the day that bowel cleansing
preparations are given and for up to 72 hours after the
procedure. Also consider withholding diuretics on the day
that bowel cleansing preparations are given.
1418 Bosentan — Bowel cleansing preparations BNF 78
Brentuximab vedotin → see monoclonal antibodies
▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone) are predicted to decrease the exposure
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the exposure to brigatinib. Adjust
brigatinib dose, p. 971.rStudy
▶ Bosentan is predicted to decrease the exposure to brigatinib.
▶ Cobicistat is predicted to increase the exposure to brigatinib.
Adjust brigatinib dose, p. 971.rStudy
▶ Brigatinib decreases the exposure to combined hormonal
. Use additional contraceptive precautions.
▶ Brigatinib potentially increases the concentration of
potentially increases the concentration of digoxin.
▶ Efavirenz is predicted to decrease the exposure to brigatinib.
▶ Enzalutamide is predicted to decrease the exposure to
▶ Etravirine is predicted to decrease the exposure to brigatinib.
▶ Grapefruit juice is predicted to increase the concentration of
▶ HIV-protease inhibitors are predicted to increase the exposure
to brigatinib. Adjust brigatinib dose, p. 971.rStudy
▶ Idelalisib is predicted to increase the exposure to brigatinib.
Adjust brigatinib dose, p. 971.rStudy
▶ Macrolides (clarithromycin) are predicted to increase the
brigatinib. Adjust brigatinib dose, p. 971.r
▶ Brigatinib potentially increases the concentration of
▶ Mitotane is predicted to decrease the exposure to brigatinib.
▶ Nevirapine is predicted to decrease the exposure to brigatinib.
▶ Brigatinib potentially decreases the concentration of opioids
(alfentanil, fentanyl). Avoid.oTheoretical
▶ Rifabutin is predicted to decrease the exposure to brigatinib.
▶ Rifampicin is predicted to decrease the exposure to brigatinib.
▶ Brigatinib potentially decreases the concentration of
▶ St John’s Wort is predicted to decrease the exposure to
▶ Brigatinib potentially decreases the concentration of
tacrolimus. Avoid.oTheoretical
Brimonidine → see TABLE 6 p. 1376 (bradycardia), TABLE 8 p. 1376
(hypotension), TABLE 11 p. 1377 (CNS depressant effects)
ROUTE-SPECIFIC INFORMATION Since systemic absorption can
follow topical application, the possibility of interactions
Brivaracetam → see antiepileptics
Brodalumab → see monoclonal antibodies
Bromocriptine → see dopamine receptor agonists
Buclizine → see antihistamines, sedating
Budesonide → see corticosteroids
Bumetanide → see loop diuretics
Bupivacaine → see anaesthetics, local
Bupropion → see TABLE 13 p. 1378 (serotonin syndrome)
▶ Bupropion is predicted to increase the exposure to
anticholinesterases, centrally acting (galantamine). Monitor and
▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone) are predicted to markedly decrease the
(valproate) increase the exposure to bupropion.
▶ Antifungals, azoles (isavuconazole) slightly increase the
exposure to bupropion. Adjust dose.oStudy
▶ Bupropion is predicted to moderately increase the exposure to
aripiprazole. Adjust aripiprazole dose, p. 395.oStudy
▶ Bupropion is predicted to markedly increase the exposure to
atomoxetine. Adjust dose.rStudy
▶ Bupropion is predicted to increase the exposure to beta
blockers, selective (metoprolol, nebivolol).oStudy
▶ Bupropion is predicted to slightly increase the exposure to
▶ Bupropion increases the risk of side-effects when given with
dopamine receptor agonists (amantadine).oStudy
is predicted to decrease the exposure to bupropion.
▶ Bupropion is predicted to increase the exposure to eliglustat.
Avoid or adjust dose—consult product literature.rStudy
▶ HIV-protease inhibitors (ritonavir) are predicted to decrease the
▶ Bupropion increases the risk of side-effects when given with
▶ Bupropion is predicted to increase the risk of intraoperative
hypertension when given with linezolid.rAnecdotal → Also
▶ Methylthioninium chloride is predicted to increase the risk of
severe hypertension when given with
Theoretical → Also see TABLE 13 p. 1378
is predicted to increase the exposure to mexiletine.
▶ Moclobemide is predicted to increase the risk of severe
Theoretical → Also see TABLE 13 p. 1378
▶ Monoamine-oxidase A and B inhibitors, irreversible are
predicted to increase the risk of severe hypertension when
given with bupropion. Avoid and for 14 days after stopping the
MAOI.rTheoretical → Also see TABLE 13 p. 1378
▶ Monoamine-oxidase B inhibitors are predicted to increase the
risk of severe hypertension when given with
Theoretical → Also see TABLE 13 p. 1378
▶ Bupropion is predicted to decrease the efficacy of opioids
▶ Bupropion is predicted to decrease the efficacy of opioids
(tramadol).rStudy → Also see TABLE 13 p. 1378
▶ Bupropion is predicted to moderately increase the exposure to
pitolisant. Use with caution and adjust dose.oStudy
is predicted to decrease the exposure to bupropion.
▶ Bupropion is predicted to increase the exposure to risperidone.
▶ Bupropion is predicted to increase the exposure to SSRIs
(dapoxetine).oTheoretical → Also see TABLE 13 p. 1378
▶ Bupropion is predicted to decrease the efficacy of tamoxifen.
▶ Bupropion is predicted to increase the exposure to tricyclic
. Monitor for toxicity and adjust dose.
▶ Bupropion is predicted to increase the exposure to
vortioxetine. Monitor and adjust dose.oStudy → Also
Buspirone → see TABLE 13 p. 1378 (serotonin syndrome)
▶ Antiarrhythmics (dronedarone) are predicted to increase the
buspirone. Use with caution and adjust dose.
▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone) are predicted to decrease the exposure
to buspirone. Use with caution and adjust dose.rStudy
▶ Antifungals, azoles (fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure to buspirone. Use with
caution and adjust dose.oStudy
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the exposure to buspirone. Adjust
BNF 78 Brentuximab vedotin — Buspirone 1419
▶ Antifungals, azoles (miconazole) are predicted to increase the
buspirone. Use with caution and adjust dose.
▶ Apalutamide is predicted to decrease the exposure to
buspirone. Avoid or monitor.oStudy
▶ Aprepitant is predicted to increase the exposure to buspirone.
Use with caution and adjust dose.oStudy
▶ Calcium channel blockers (diltiazem, verapamil) are predicted to
increase the exposure to buspirone. Use with caution and
▶ Cobicistat is predicted to increase the exposure to buspirone.
Adjust buspirone dose, p. 342.rStudy
▶ Crizotinib is predicted to increase the exposure to buspirone.
Use with caution and adjust dose.oStudy
▶ Enzalutamide is predicted to decrease the exposure to
buspirone. Use with caution and adjust dose.rStudy
▶ Grapefruit juice increases the exposure to buspirone. Avoid.
▶ HIV-protease inhibitors are predicted to increase the exposure
to buspirone. Adjust buspirone dose, p. 342.rStudy
▶ Idelalisib is predicted to increase the exposure to buspirone.
Adjust buspirone dose, p. 342.rStudy
▶ Imatinib is predicted to increase the exposure to buspirone.
Use with caution and adjust dose.oStudy
▶ Buspirone is predicted to increase the risk of elevated blood
pressure when given with linezolid. Avoid.rTheoretical →
▶ Macrolides (clarithromycin) are predicted to increase the
buspirone. Adjust buspirone dose, p. 342.r
▶ Macrolides (erythromycin) are predicted to increase the
exposure to buspirone. Use with caution and adjust dose.
▶ Mitotane is predicted to decrease the exposure to buspirone.
Use with caution and adjust dose.rStudy
▶ Buspirone is predicted to increase the risk of elevated blood
pressure when given with monoamine-oxidase A and B
inhibitors, irreversible. Avoid.rAnecdotal → Also see
▶ Netupitant is predicted to increase the exposure to buspirone.
Use with caution and adjust dose.oStudy
▶ Nilotinib is predicted to increase the exposure to buspirone.
Use with caution and adjust dose.oStudy
▶ Rifampicin is predicted to decrease the exposure to buspirone.
Use with caution and adjust dose.rStudy
Busulfan → see alkylating agents
Cabergoline → see dopamine receptor agonists
Cabozantinib → see TABLE 15 p. 1378 (myelosuppression), TABLE 9
p. 1377 (QT-interval prolongation)
▶ Antiarrhythmics (dronedarone) are predicted to increase the
exposure to cabozantinib.oTheoretical → Also see TABLE 9
▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone) moderately decrease the exposure to
▶ Antifungals, azoles (fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure to
Theoretical → Also see TABLE 9 p. 1377
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole)
slightly increase the exposure to
Study → Also see TABLE 9 p. 1377
cabozantinib.o ▶ Aprepitant is predicted to increase the exposure to
▶ Bosentan is predicted to decrease the exposure to
▶ Calcium channel blockers (diltiazem, verapamil) are predicted to
increase the exposure to cabozantinib.oTheoretical
slightly increases the exposure to cabozantinib.
▶ Cabozantinib is predicted to increase the risk of bleeding
events when given with coumarins.rTheoretical
▶ Crizotinib is predicted to increase the exposure to
cabozantinib.oTheoretical → Also see TABLE 15 p. 1378 →
▶ Efavirenz is predicted to decrease the exposure to
cabozantinib.oTheoretical → Also see TABLE 9 p. 1377
▶ Enzalutamide moderately decreases the exposure to
▶ Grapefruit juice is predicted to increase the exposure to
▶ HIV-protease inhibitors slightly increase the exposure to
cabozantinib.oStudy → Also see TABLE 9 p. 1377
slightly increases the exposure to cabozantinib.
Study → Also see TABLE 15 p. 1378
is predicted to increase the exposure to cabozantinib.
Theoretical → Also see TABLE 15 p. 1378
▶ Macrolides (clarithromycin) slightly increase the exposure to
cabozantinib.oStudy → Also see TABLE 9 p. 1377
▶ Macrolides (erythromycin) are predicted to increase the
exposure to cabozantinib.oTheoretical → Also see TABLE 9
▶ Mitotane moderately decreases the exposure to cabozantinib.
Avoid.oStudy → Also see TABLE 15 p. 1378
▶ Netupitant is predicted to increase the exposure to
▶ Nevirapine is predicted to decrease the exposure to
is predicted to increase the exposure to cabozantinib.
Theoretical → Also see TABLE 15 p. 1378 → Also see TABLE 9
▶ Cabozantinib is predicted to increase the risk of bleeding
events when given with phenindione.rTheoretical
▶ Rifampicin moderately decreases the exposure to cabozantinib.
▶ St John’s Wort is predicted to decrease the exposure to
▶ Caffeine citrate decreases the efficacy of antiarrhythmics
(adenosine). Separate administration by 24 hours.nStudy
▶ Antiepileptics (fosphenytoin, phenytoin) are predicted to
moderately increase the clearance of caffeine citrate. Monitor
▶ HIV-protease inhibitors (ritonavir) are predicted to moderately
increase the clearance of caffeine citrate. Monitor and adjust
▶ Leflunomide is predicted to moderately increase the clearance
of caffeine citrate. Monitor and adjust dose.oStudy
▶ Rifampicin is predicted to moderately increase the clearance of
caffeine citrate. Monitor and adjust dose.oStudy
▶ SSRIs (fluvoxamine) markedly decrease the clearance of
caffeine citrate. Monitor and adjust dose.rStudy
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