▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) are predicted to very markedly decrease

the exposure to bosutinib. Avoid.rStudy

▶ Antifungals, azoles (fluconazole, isavuconazole, posaconazole)

are predicted to increase the exposure to bosutinib. Avoid or

adjust dose.rTheoretical → Also see TABLE 9 p. 1377

▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are

predicted to markedly increase the exposure to bosutinib.

Avoid or adjust dose.rStudy → Also see TABLE 9 p. 1377

▶ Apalutamide is predicted to decrease the exposure to

bosutinib. Avoid or monitor.oStudy → Also see TABLE 9

p. 1377

▶ Aprepitant is predicted to increase the exposure to bosutinib.

Avoid or adjust dose.rTheoretical

▶ Bosentan is predicted to decrease the exposure to bosutinib.

Avoid.rTheoretical

▶ Calcium channel blockers (diltiazem, verapamil) are predicted to

increase the exposure to

r

bosutinib. Avoid or adjust dose.

Theoretical

▶ Cobicistat is predicted to markedly increase the exposure to

bosutinib. Avoid or adjust dose.rStudy

▶ Bosutinib is predicted to increase the risk of bleeding events

when given with coumarins.rTheoretical

▶ Crizotinib is predicted to increase the exposure to bosutinib.

Avoid or adjust dose.rTheoretical → Also see TABLE 15

p. 1378 → Also see TABLE 9 p. 1377

▶ Efavirenz is predicted to decrease the exposure to bosutinib.

Avoid.rTheoretical → Also see TABLE 9 p. 1377

▶ Enzalutamide is predicted to very markedly decrease the

exposure to bosutinib. Avoid.rStudy

▶ Etravirine is predicted to decrease the exposure to bosutinib.

Avoid.rTheoretical

▶ Fosaprepitant is predicted to increase the exposure to

bosutinib.rTheoretical

▶ Grapefruit juice is predicted to increase the exposure to

bosutinib. Avoid.oTheoretical

▶ H2 receptor antagonists are predicted to decrease the

absorption of bosutinib.oTheoretical

▶ HIV-protease inhibitors are predicted to markedly increase the

exposure to bosutinib. Avoid or adjust dose.rStudy →

Also see TABLE 9 p. 1377

▶ Idelalisib is predicted to markedly increase the exposure to

bosutinib. Avoid or adjust dose.rStudy → Also see TABLE 15

p. 1378

▶ Imatinib is predicted to increase the exposure to bosutinib.

Avoid or adjust dose.rTheoretical → Also see TABLE 15

p. 1378

▶ Macrolides (clarithromycin) are predicted to markedly increase

the exposure to bosutinib. Avoid or adjust dose.rStudy →

Also see TABLE 9 p. 1377

▶ Macrolides (erythromycin) are predicted to increase the

exposure to

Theoretical →

bosutinib

Also see TABLE 9

. Avoid or adjust dose.

p. 1377

r

▶ Mitotane is predicted to very markedly decrease the exposure

to bosutinib. Avoid.rStudy → Also see TABLE 15 p. 1378

▶ Modafinil is predicted to decrease the exposure to bosutinib.

Avoid.rTheoretical

▶ Netupitant is predicted to increase the exposure to bosutinib.

Avoid or adjust dose.rTheoretical

▶ Nevirapine is predicted to decrease the exposure to bosutinib.

Avoid.rTheoretical

▶ Nilotinib is predicted to increase the exposure to bosutinib.

Avoid or adjust dose.rTheoretical → Also see TABLE 15

p. 1378 → Also see TABLE 9 p. 1377

▶ Bosutinib is predicted to increase the risk of bleeding events

when given with phenindione.rTheoretical

▶ Pitolisant is predicted to decrease the exposure to bosutinib.

Avoid.rTheoretical

▶ Proton pump inhibitors are predicted to decrease the

absorption of bosutinib.oStudy

▶ Rifampicin is predicted to very markedly decrease the

exposure to bosutinib. Avoid.rStudy

▶ St John’s Wort is predicted to decrease the exposure to

bosutinib. Avoid.rTheoretical

Botulinum toxin type A → see TABLE 20 p. 1379 (neuromuscular

blocking effects)

Botulinum toxin type B → see TABLE 20 p. 1379 (neuromuscular

blocking effects)

Bowel cleansing preparations

SEPARATION OF ADMINISTRATION Other oral drugs should not be

taken 1 hour before, or after, administration of bowel

cleansing preparations because absorption may be impaired.

Consider withholding ACE inhibitors, angiotensin-II receptor

antagonists, and NSAIDs on the day that bowel cleansing

preparations are given and for up to 72 hours after the

procedure. Also consider withholding diuretics on the day

that bowel cleansing preparations are given.

1418 Bosentan — Bowel cleansing preparations BNF 78

Interactions | Appendix 1

A1

Brentuximab vedotin → see monoclonal antibodies

Brigatinib

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) are predicted to decrease the exposure

to brigatinib. Avoid.rStudy

▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are

predicted to increase the exposure to brigatinib. Adjust

brigatinib dose, p. 971.rStudy

▶ Bosentan is predicted to decrease the exposure to brigatinib.

Avoid.rStudy

▶ Cobicistat is predicted to increase the exposure to brigatinib.

Adjust brigatinib dose, p. 971.rStudy

▶ Brigatinib decreases the exposure to combined hormonal

contraceptives

r

. Use additional contraceptive precautions.

Theoretical

▶ Brigatinib potentially increases the concentration of

dabigatran.oTheoretical

▶ Brigatinib

o

potentially increases the concentration of digoxin.

Theoretical

▶ Efavirenz is predicted to decrease the exposure to brigatinib.

Avoid.rStudy

▶ Enzalutamide is predicted to decrease the exposure to

brigatinib. Avoid.rStudy

▶ Etravirine is predicted to decrease the exposure to brigatinib.

Avoid.oTheoretical

▶ Grapefruit juice is predicted to increase the concentration of

brigatinib. Avoid.rStudy

▶ HIV-protease inhibitors are predicted to increase the exposure

to brigatinib. Adjust brigatinib dose, p. 971.rStudy

▶ Idelalisib is predicted to increase the exposure to brigatinib.

Adjust brigatinib dose, p. 971.rStudy

▶ Macrolides (clarithromycin) are predicted to increase the

exposure to

Study

brigatinib. Adjust brigatinib dose, p. 971.r

▶ Brigatinib potentially increases the concentration of

methotrexate.oTheoretical

▶ Mitotane is predicted to decrease the exposure to brigatinib.

Avoid.rStudy

▶ Nevirapine is predicted to decrease the exposure to brigatinib.

Avoid.rStudy

▶ Brigatinib potentially decreases the concentration of opioids

(alfentanil, fentanyl). Avoid.oTheoretical

▶ Rifabutin is predicted to decrease the exposure to brigatinib.

Avoid.oTheoretical

▶ Rifampicin is predicted to decrease the exposure to brigatinib.

Avoid.rStudy

▶ Brigatinib potentially decreases the concentration of

sirolimus. Avoid.oTheoretical

▶ St John’s Wort is predicted to decrease the exposure to

brigatinib. Avoid.rStudy

▶ Brigatinib potentially decreases the concentration of

tacrolimus. Avoid.oTheoretical

Brimonidine → see TABLE 6 p. 1376 (bradycardia), TABLE 8 p. 1376

(hypotension), TABLE 11 p. 1377 (CNS depressant effects)

Brinzolamide

ROUTE-SPECIFIC INFORMATION Since systemic absorption can

follow topical application, the possibility of interactions

should be borne in mind.

Brivaracetam → see antiepileptics

Brodalumab → see monoclonal antibodies

Bromfenac → see NSAIDs

Bromocriptine → see dopamine receptor agonists

Buclizine → see antihistamines, sedating

Budesonide → see corticosteroids

Bumetanide → see loop diuretics

Bupivacaine → see anaesthetics, local

Buprenorphine → see opioids

Bupropion → see TABLE 13 p. 1378 (serotonin syndrome)

▶ Bupropion is predicted to increase the exposure to

anticholinesterases, centrally acting (galantamine). Monitor and

adjust dose.oStudy

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) are predicted to markedly decrease the

exposure to bupropion.rStudy

▶ Antiepileptics

r

(valproate) increase the exposure to bupropion.

Study

▶ Antifungals, azoles (isavuconazole) slightly increase the

exposure to bupropion. Adjust dose.oStudy

▶ Bupropion is predicted to moderately increase the exposure to

aripiprazole. Adjust aripiprazole dose, p. 395.oStudy

▶ Bupropion is predicted to markedly increase the exposure to

atomoxetine. Adjust dose.rStudy

▶ Bupropion is predicted to increase the exposure to beta

blockers, selective (metoprolol, nebivolol).oStudy

▶ Bupropion is predicted to slightly increase the exposure to

darifenacin.nStudy

▶ Bupropion increases the risk of side-effects when given with

dopamine receptor agonists (amantadine).oStudy

▶ Efavirenz

o

is predicted to decrease the exposure to bupropion.

Study

▶ Bupropion is predicted to increase the exposure to eliglustat.

Avoid or adjust dose—consult product literature.rStudy

▶ HIV-protease inhibitors (ritonavir) are predicted to decrease the

exposure to bupropion.oStudy

▶ Bupropion increases the risk of side-effects when given with

levodopa.oStudy

▶ Bupropion is predicted to increase the risk of intraoperative

hypertension when given with linezolid.rAnecdotal → Also

see TABLE 13 p. 1378

▶ Methylthioninium chloride is predicted to increase the risk of

severe hypertension when given with

r

bupropion. Avoid.

Theoretical → Also see TABLE 13 p. 1378

▶ Bupropion

o

is predicted to increase the exposure to mexiletine.

Study

▶ Moclobemide is predicted to increase the risk of severe

hypertension when given with

Theoretical → Also see TABLE 13 p. 1378

bupropion. Avoid.r

▶ Monoamine-oxidase A and B inhibitors, irreversible are

predicted to increase the risk of severe hypertension when

given with bupropion. Avoid and for 14 days after stopping the

MAOI.rTheoretical → Also see TABLE 13 p. 1378

▶ Monoamine-oxidase B inhibitors are predicted to increase the

risk of severe hypertension when given with

o

bupropion. Avoid.

Theoretical → Also see TABLE 13 p. 1378

▶ Bupropion is predicted to decrease the efficacy of opioids

(codeine).oTheoretical

▶ Bupropion is predicted to decrease the efficacy of opioids

(tramadol).rStudy → Also see TABLE 13 p. 1378

▶ Bupropion is predicted to moderately increase the exposure to

pitolisant. Use with caution and adjust dose.oStudy

▶ Rifampicin

o

is predicted to decrease the exposure to bupropion.

Study

▶ Bupropion is predicted to increase the exposure to risperidone.

Adjust dose.oStudy

▶ Bupropion is predicted to increase the exposure to SSRIs

(dapoxetine).oTheoretical → Also see TABLE 13 p. 1378

▶ Bupropion is predicted to decrease the efficacy of tamoxifen.

Avoid.rStudy

▶ Bupropion is predicted to increase the exposure to tricyclic

antidepressants

Study → Also see TABLE 13

. Monitor for toxicity and adjust dose.

p. 1378

r

▶ Bupropion is predicted to increase the exposure to

vortioxetine. Monitor and adjust dose.oStudy → Also

see TABLE 13 p. 1378

Buspirone → see TABLE 13 p. 1378 (serotonin syndrome)

▶ Antiarrhythmics (dronedarone) are predicted to increase the

exposure to

o

buspirone. Use with caution and adjust dose.

Study

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) are predicted to decrease the exposure

to buspirone. Use with caution and adjust dose.rStudy

▶ Antifungals, azoles (fluconazole, isavuconazole, posaconazole)

are predicted to increase the exposure to buspirone. Use with

caution and adjust dose.oStudy

▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are

predicted to increase the exposure to buspirone. Adjust

buspirone dose, p. 342.rStudy

BNF 78 Brentuximab vedotin — Buspirone 1419

Interactions | Appendix 1

A1

Buspirone (continued)

▶ Antifungals, azoles (miconazole) are predicted to increase the

concentration of

o

buspirone. Use with caution and adjust dose.

Theoretical

▶ Apalutamide is predicted to decrease the exposure to

buspirone. Avoid or monitor.oStudy

▶ Aprepitant is predicted to increase the exposure to buspirone.

Use with caution and adjust dose.oStudy

▶ Calcium channel blockers (diltiazem, verapamil) are predicted to

increase the exposure to buspirone. Use with caution and

adjust dose.oStudy

▶ Cobicistat is predicted to increase the exposure to buspirone.

Adjust buspirone dose, p. 342.rStudy

▶ Crizotinib is predicted to increase the exposure to buspirone.

Use with caution and adjust dose.oStudy

▶ Enzalutamide is predicted to decrease the exposure to

buspirone. Use with caution and adjust dose.rStudy

▶ Grapefruit juice increases the exposure to buspirone. Avoid.

nStudy

▶ HIV-protease inhibitors are predicted to increase the exposure

to buspirone. Adjust buspirone dose, p. 342.rStudy

▶ Idelalisib is predicted to increase the exposure to buspirone.

Adjust buspirone dose, p. 342.rStudy

▶ Imatinib is predicted to increase the exposure to buspirone.

Use with caution and adjust dose.oStudy

▶ Buspirone is predicted to increase the risk of elevated blood

pressure when given with linezolid. Avoid.rTheoretical →

Also see TABLE 13 p. 1378

▶ Macrolides (clarithromycin) are predicted to increase the

exposure to

Study

buspirone. Adjust buspirone dose, p. 342.r

▶ Macrolides (erythromycin) are predicted to increase the

o

exposure to buspirone. Use with caution and adjust dose.

Study

▶ Mitotane is predicted to decrease the exposure to buspirone.

Use with caution and adjust dose.rStudy

▶ Buspirone is predicted to increase the risk of elevated blood

pressure when given with monoamine-oxidase A and B

inhibitors, irreversible. Avoid.rAnecdotal → Also see

TABLE 13 p. 1378

▶ Netupitant is predicted to increase the exposure to buspirone.

Use with caution and adjust dose.oStudy

▶ Nilotinib is predicted to increase the exposure to buspirone.

Use with caution and adjust dose.oStudy

▶ Rifampicin is predicted to decrease the exposure to buspirone.

Use with caution and adjust dose.rStudy

Busulfan → see alkylating agents

Cabazitaxel → see taxanes

Cabergoline → see dopamine receptor agonists

Cabozantinib → see TABLE 15 p. 1378 (myelosuppression), TABLE 9

p. 1377 (QT-interval prolongation)

▶ Antiarrhythmics (dronedarone) are predicted to increase the

exposure to cabozantinib.oTheoretical → Also see TABLE 9

p. 1377

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) moderately decrease the exposure to

cabozantinib. Avoid.oStudy

▶ Antifungals, azoles (fluconazole, isavuconazole, posaconazole)

are predicted to increase the exposure to

o

cabozantinib.

Theoretical → Also see TABLE 9 p. 1377

▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole)

slightly increase the exposure to

Study → Also see TABLE 9 p. 1377

cabozantinib.o ▶ Aprepitant is predicted to increase the exposure to

cabozantinib.oTheoretical

▶ Bosentan is predicted to decrease the exposure to

cabozantinib.oTheoretical

▶ Calcium channel blockers (diltiazem, verapamil) are predicted to

increase the exposure to cabozantinib.oTheoretical

▶ Cobicistat

o

slightly increases the exposure to cabozantinib.

Study

▶ Cabozantinib is predicted to increase the risk of bleeding

events when given with coumarins.rTheoretical

▶ Crizotinib is predicted to increase the exposure to

cabozantinib.oTheoretical → Also see TABLE 15 p. 1378 →

Also see TABLE 9 p. 1377

▶ Efavirenz is predicted to decrease the exposure to

cabozantinib.oTheoretical → Also see TABLE 9 p. 1377

▶ Enzalutamide moderately decreases the exposure to

cabozantinib. Avoid.oStudy

▶ Grapefruit juice is predicted to increase the exposure to

cabozantinib.oTheoretical

▶ HIV-protease inhibitors slightly increase the exposure to

cabozantinib.oStudy → Also see TABLE 9 p. 1377

▶ Idelalisib

o

slightly increases the exposure to cabozantinib.

Study → Also see TABLE 15 p. 1378

▶ Imatinib

o

is predicted to increase the exposure to cabozantinib.

Theoretical → Also see TABLE 15 p. 1378

▶ Macrolides (clarithromycin) slightly increase the exposure to

cabozantinib.oStudy → Also see TABLE 9 p. 1377

▶ Macrolides (erythromycin) are predicted to increase the

exposure to cabozantinib.oTheoretical → Also see TABLE 9

p. 1377

▶ Mitotane moderately decreases the exposure to cabozantinib.

Avoid.oStudy → Also see TABLE 15 p. 1378

▶ Netupitant is predicted to increase the exposure to

cabozantinib.oTheoretical

▶ Nevirapine is predicted to decrease the exposure to

cabozantinib.oTheoretical

▶ Nilotinib

o

is predicted to increase the exposure to cabozantinib.

Theoretical → Also see TABLE 15 p. 1378 → Also see TABLE 9

p. 1377

▶ Cabozantinib is predicted to increase the risk of bleeding

events when given with phenindione.rTheoretical

▶ Rifampicin moderately decreases the exposure to cabozantinib.

Avoid.oStudy

▶ St John’s Wort is predicted to decrease the exposure to

cabozantinib.oTheoretical

Caffeine citrate

▶ Caffeine citrate decreases the efficacy of antiarrhythmics

(adenosine). Separate administration by 24 hours.nStudy

▶ Antiepileptics (fosphenytoin, phenytoin) are predicted to

moderately increase the clearance of caffeine citrate. Monitor

and adjust dose.oStudy

▶ HIV-protease inhibitors (ritonavir) are predicted to moderately

increase the clearance of caffeine citrate. Monitor and adjust

dose.oStudy

▶ Leflunomide is predicted to moderately increase the clearance

of caffeine citrate. Monitor and adjust dose.oStudy

▶ Rifampicin is predicted to moderately increase the clearance of

caffeine citrate. Monitor and adjust dose.oStudy

▶ SSRIs (fluvoxamine) markedly decrease the clearance of

caffeine citrate. Monitor and adjust dose.rStudy

▶ Teriflunomide is predicted to moderately increase the

o

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