procarbazine.

Anecdotal

▶ Fosphenytoin is predicted to increase the risk of

Anecdotal

hypersensitivity when given with procarbazine.r

▶ Valproate potentially increases the concentration of propofol.

Adjust dose.rTheoretical

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) are predicted to decrease the exposure

to quetiapine.oStudy → Also see TABLE 11 p. 1377

▶ Valproate potentially increases the risk of neutropenia when

given with quetiapine.oStudy

▶ Quinolones (ciprofloxacin) affect the concentration of

antiepileptics (fosphenytoin, phenytoin). Monitor concentration

and adjust dose.rStudy

▶ Antiepileptics (fosphenytoin, phenobarbital, phenytoin,

primidone) are predicted to affect the exposure to raltegravir.

Use with caution or avoid.oTheoretical

▶ Carbamazepine is predicted to affect the exposure to

raltegravir.oTheoretical

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) are predicted to decrease the exposure

to ranolazine. Avoid.rStudy

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) are predicted to decrease the exposure

to reboxetine.oAnecdotal

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) are predicted to decrease the exposure

to regorafenib. Avoid.oStudy

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) are predicted to decrease the exposure

to

o

repaglinide. Monitor blood glucose and adjust dose.

Study

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) are predicted to markedly decrease the

exposure to ribociclib. Avoid.rStudy

▶ Antiepileptics (phenobarbital, primidone) are predicted to

decrease the exposure to rifampicin and rifampicin is predicted

to decrease the exposure to antiepileptics (phenobarbital,

primidone). Use with caution and adjust dose.oStudy

▶ Rifampicin decreases the concentration of antiepileptics

(fosphenytoin, phenytoin)

o

. Use with caution and adjust dose.

Study

▶ Rifampicin slightly decreases the exposure to brivaracetam.

Adjust dose.oStudy

▶ Rifampicin markedly increases the clearance of lamotrigine.

Adjust lamotrigine dose, p. 318.oStudy

▶ Rifampicin is predicted to decrease the exposure to

perampanel. Monitor and adjust dose.oStudy

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) markedly decrease the exposure to

rilpivirine. Avoid.rStudy

BNF 78 Antiepileptics — Antiepileptics 1397

Interactions | Appendix 1

A1

Antiepileptics (continued)

▶ Oxcarbazepine is predicted to decrease the concentration of

rilpivirine. Avoid.rTheoretical

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) are predicted to decrease the exposure

to risperidone. Adjust dose.oStudy → Also see TABLE 11

p. 1377

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) are predicted to moderately decrease

the exposure to rivaroxaban. Avoid unless patient can be

monitored for signs of thrombosis.rStudy

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) are predicted to decrease the exposure

to roflumilast. Avoid.oStudy

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) are predicted to markedly decrease the

exposure to rolapitant. Avoid.rStudy

▶ Rucaparib is predicted to increase the exposure to phenytoin.

Monitor and adjust dose.oStudy

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) are predicted to decrease the exposure

to ruxolitinib. Monitor and adjust dose.oStudy

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) are predicted to moderately decrease

the exposure to saxagliptin.oStudy

▶ Antiepileptics (carbamazepine, fosphenytoin, phenytoin) are

predicted to decrease the exposure to the active metabolite of

selexipag. Adjust dose.oStudy

▶ Valproate

q

is predicted to increase the exposure to selexipag.

Theoretical

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) are predicted to decrease the

concentration of sirolimus. Avoid.rStudy

▶ Valproate increases the exposure to sodium oxybate. Adjust

sodium oxybate dose, p. 491.oStudy

▶ Valproate potentially decreases the effects of sodium

phenylbutyrate.oAnecdotal

▶ Antiepileptics (fosphenytoin, oxcarbazepine, phenobarbital,

phenytoin, primidone) are predicted to decrease the exposure

to sofosbuvir. Avoid.rTheoretical

▶ Carbamazepine is predicted to decrease the exposure to

sofosbuvir. Avoid.rStudy

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) are predicted to decrease the exposure

to solifenacin.oTheoretical

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) are predicted to decrease the exposure

to sorafenib.oTheoretical

▶ SSRIs (fluoxetine, fluvoxamine) are predicted to increase the

concentration of antiepileptics (fosphenytoin, phenytoin).

Monitor and adjust dose.rAnecdotal

▶ SSRIs (sertraline) potentially increase the risk of toxicity when

given with antiepileptics (fosphenytoin, phenytoin). Monitor

concentration and adjust dose.rAnecdotal

▶ Antiepileptics (fosphenytoin, phenytoin) decrease the

concentration of SSRIs (paroxetine).oStudy

▶ St John’s Wort is predicted to decrease the concentration of

antiepileptics (fosphenytoin, phenobarbital, phenytoin,

primidone). Avoid.rTheoretical

▶ St John’s Wort is predicted to decrease the exposure to

brivaracetam.oTheoretical

▶ St John’s Wort is predicted to decrease the concentration of

carbamazepine. Monitor and adjust dose.oTheoretical

▶ St John’s Wort is predicted to decrease the exposure to

perampanel. Monitor and adjust dose.oTheoretical

▶ St John’s Wort is predicted to decrease the exposure to

tiagabine. Avoid.nTheoretical

▶ Antiepileptics (carbamazepine, eslicarbazepine) are predicted to

decrease the exposure to statins (atorvastatin). Monitor and

adjust dose.oTheoretical → Also see TABLE 1 p. 1375

▶ Antiepileptics (fosphenytoin, phenytoin) potentially decrease

the exposure to

Anecdotal

statins (atorvastatin, simvastatin).o

▶ Carbamazepine moderately decreases the exposure to statins

(simvastatin). Monitor and adjust dose.rStudy → Also see

TABLE 1 p. 1375

▶ Eslicarbazepine moderately decreases the exposure to statins

(simvastatin). Monitor and adjust dose.oStudy

▶ Sulfonamides (sulfadiazine) are predicted to increase the

concentration of

o

fosphenytoin. Monitor and adjust dose.

Study

▶ Sulfonamides (sulfadiazine) increase the concentration of

phenytoin. Monitor and adjust dose.oStudy

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) are predicted to decrease the exposure

to

Study

sunitinib. Avoid or adjust sunitinib dose, p. 999.o ▶ Antiepileptics (fosphenytoin, phenytoin) increase the effects of

suxamethonium.oStudy

▶ Carbamazepine increases the risk of prolonged neuromuscular

blockade when given with suxamethonium.oStudy

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) decrease the concentration of

tacrolimus. Monitor and adjust dose.rStudy

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) are predicted to decrease the exposure

to taxanes (cabazitaxel, paclitaxel). Avoid.rStudy → Also

see TABLE 12 p. 1378

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) are predicted to decrease the exposure

to taxanes (docetaxel).rTheoretical → Also see TABLE 12

p. 1378

▶ Tegafur potentially increases the concentration of

antiepileptics (fosphenytoin, phenytoin). Monitor concentration

and adjust dose.rAnecdotal

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) are predicted to decrease the

concentration of temsirolimus. Avoid.rStudy

▶ Antiepileptics (carbamazepine, fosphenytoin, oxcarbazepine,

phenobarbital, phenytoin, primidone) are predicted to decrease

the exposure to

Theoretical

tenofovir alafenamide. Avoid.o ▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) decrease the exposure to tetracyclines

(doxycycline). Monitor and adjust dose.oStudy → Also

see TABLE 1 p. 1375

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) are predicted to decrease the exposure

to tezacaftor. Avoid.rTheoretical

▶ Antiepileptics (fosphenytoin, phenytoin) are predicted to

decrease the exposure to

Study

theophylline. Adjust dose.o ▶ Antiepileptics (phenobarbital, primidone) are predicted to

increase the clearance of

Theoretical

theophylline. Adjust dose.o ▶ Carbamazepine potentially increases the clearance of

theophylline and theophylline decreases the exposure to

carbamazepine. Adjust dose.oAnecdotal

▶ Stiripentol is predicted to increase the exposure to

theophylline. Avoid.oTheoretical

▶ Antiepileptics (carbamazepine, fosphenytoin, phenytoin) are

predicted to increase the risk of hypothyroidism when given

with thyroid hormones.oStudy

▶ Antiepileptics (phenobarbital, primidone) are predicted to

decrease the effects of thyroid hormones.oTheoretical

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) are predicted to markedly decrease the

exposure to ticagrelor. Avoid.rStudy

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) are predicted to decrease the exposure

to tivozanib.rStudy

▶ Antiepileptics (fosphenytoin, phenytoin) moderately decrease

the exposure to tizanidine.nStudy

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) are predicted to decrease the exposure

to tofacitinib. Avoid.rStudy

▶ Antiepileptics (carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone) are predicted to decrease the exposure

1398 Antiepileptics — Antiepileptics BNF 78

Interactions | Appendix 1

A1

Comments

Search This Blog

Archive

Show more

Popular posts from this blog

TRIPASS XR تري باس

CELEPHI 200 MG, Gélule

ZENOXIA 15 MG, Comprimé

VOXCIB 200 MG, Gélule

Kana Brax Laberax

فومي كايند

بعض الادويه نجد رموز عليها مثل IR ، MR, XR, CR, SR , DS ماذا تعني هذه الرموز

NIFLURIL 700 MG, Suppositoire adulte

Antifongiques مضادات الفطريات

Popular posts from this blog

علاقة البيبي بالفراولة بالالفا فيتو بروتين

التغيرات الخمس التي تحدث للجسم عند المشي

إحصائيات سنة 2020 | تعداد سكَان دول إفريقيا تنازليا :

ما هو الليمونير للأسنان ؟

ACUPAN 20 MG, Solution injectable

CELEPHI 200 MG, Gélule

الام الظهر

VOXCIB 200 MG, Gélule

ميبستان

Popular posts from this blog

TRIPASS XR تري باس

CELEPHI 200 MG, Gélule

Popular posts from this blog

TRIPASS XR تري باس

CELEPHI 200 MG, Gélule

ZENOXIA 15 MG, Comprimé

VOXCIB 200 MG, Gélule

Kana Brax Laberax

فومي كايند

بعض الادويه نجد رموز عليها مثل IR ، MR, XR, CR, SR , DS ماذا تعني هذه الرموز

NIFLURIL 700 MG, Suppositoire adulte

Antifongiques مضادات الفطريات

Popular posts from this blog

Kana Brax Laberax

TRIPASS XR تري باس

PARANTAL 100 MG, Suppositoire بارانتال 100 مجم تحاميل

الكبد الدهني Fatty Liver

الم اسفل الظهر (الحاد) الذي يظهر بشكل مفاجئ bal-agrisi

SEDALGIC 37.5 MG / 325 MG, Comprimé pelliculé [P] سيدالجيك 37.5 مجم / 325 مجم ، قرص مغلف [P]

نمـو الدمـاغ والتطـور العقـلي لـدى الطفـل

CELEPHI 200 MG, Gélule

أخطر أنواع المخدرات فى العالم و الشرق الاوسط

Archive

Show more