side-effects when given with sympathomimetics, inotropic.
▶ Entacapone is predicted to increase the risk of cardiovascular
side-effects when given with sympathomimetics, vasoconstrictor
(adrenaline/epinephrine, noradrenaline/norepinephrine)
▶ Antacids (aluminium hydroxide) increase the risk of blocked
enteral or nasogastric tubes when given with
▶ Enteral feeds decrease the absorption of antiepileptics
▶ Enteral feeds (vitamin-K containing) potentially decrease the
anticoagulant effect of coumarins.rAnecdotal
▶ Enteral feeds (vitamin-K containing) potentially decrease the
effects of phenindione.rTheoretical
▶ Enteral feeds decrease the exposure to quinolones
▶ Sucralfate increases the risk of blocked enteral or nasogastric
tubes when given with enteral feeds. Separate administration
decrease the exposure to theophylline.o
GENERAL INFORMATION Caution with concurrent
chemotherapy—safety and efficacy not established.
▶ Enzalutamide is predicted to markedly decrease the exposure
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to
aldosterone antagonists (eplerenone). Avoid.oTheoretical
▶ Enzalutamide is predicted to decrease the exposure to
alprazolam. Adjust dose.oTheoretical
▶ Enzalutamide is predicted to decrease the exposure to
antiarrhythmics (disopyramide, dronedarone). Avoid.r
▶ Enzalutamide is predicted to decrease the efficacy of
antiarrhythmics (propafenone).oStudy
▶ Enzalutamide is predicted to decrease the exposure to
anticholinesterases, centrally acting (donepezil).nStudy
▶ Enzalutamide is predicted to slightly decrease the exposure to
antiepileptics (brivaracetam).oTheoretical
▶ Enzalutamide is predicted to decrease the exposure to
antifungals, azoles (isavuconazole). Avoid.rStudy
▶ Enzalutamide is predicted to decrease the exposure to
antimalarials (artemether) (with lumefantrine). Avoid.r
▶ Enzalutamide is predicted to decrease the concentration of
antimalarials (piperaquine). Avoid.oTheoretical
▶ Enzalutamide is predicted to moderately decrease the
exposure to apixaban. Use with caution or avoid.rStudy
▶ Enzalutamide moderately decreases the exposure to
▶ Enzalutamide is predicted to markedly decrease the exposure
▶ Enzalutamide is predicted to moderately decrease the
exposure to aripiprazole. Adjust aripiprazole dose, p. 395.
▶ Enzalutamide is predicted to decrease the exposure to axitinib.
decreases the exposure to bedaquiline. Avoid.
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide slightly decreases the exposure to bortezomib.
affects the exposure to bosentan. Avoid.r
▶ Enzalutamide is predicted to very markedly decrease the
exposure to bosutinib. Avoid.rStudy
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to
buspirone. Use with caution and adjust dose.rStudy
▶ Enzalutamide moderately decreases the exposure to
▶ Enzalutamide is predicted to decrease the exposure to calcium
channel blockers (amlodipine, felodipine, lacidipine,
lercanidipine, nicardipine, nifedipine, nimodipine). Monitor and
▶ Enzalutamide is predicted to decrease the exposure to calcium
channel blockers (diltiazem, verapamil).rStudy
▶ Enzalutamide is predicted to decrease the exposure to
cannabis extract. Avoid.rTheoretical
▶ Enzalutamide is predicted to decrease the exposure to
cariprazine. Avoid.rTheoretical
▶ Enzalutamide is predicted to decrease the exposure to
decreases the concentration of ciclosporin.
is predicted to alter the effects of cilostazol.
▶ Enzalutamide is predicted to decrease the exposure to
cinacalcet. Monitor and adjust dose.oStudy
1450 Encorafenib — Enzalutamide BNF 78
▶ Enzalutamide decreases the exposure to clomethiazole.
Monitor and adjust dose.oStudy
▶ Clopidogrel moderately increases the exposure to
. Avoid or adjust enzalutamide dose, p. 947.r
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to
cobicistat. Avoid.rTheoretical
▶ Enzalutamide is predicted to decrease the exposure to
cobimetinib. Avoid.rTheoretical
▶ Enzalutamide is predicted to decrease the exposure to
corticosteroids (budesonide, deflazacort, dexamethasone,
fludrocortisone, hydrocortisone, methylprednisolone,
▶ Enzalutamide is predicted to decrease the exposure to
corticosteroids (fluticasone).qTheoretical
▶ Enzalutamide potentially decreases the exposure to coumarins.
Avoid or adjust dose and monitor INR.rStudy
▶ Enzalutamide is predicted to markedly decrease the exposure
▶ Enzalutamide is predicted to decrease the exposure to
dabrafenib. Avoid.oTheoretical
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to markedly decrease the exposure
▶ Enzalutamide is predicted to slightly decrease the exposure to
▶ Enzalutamide decreases the exposure to dolutegravir. Adjust
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to elbasvir.
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the concentration of
elvitegravir. Avoid.rTheoretical
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the effects of
▶ Enzalutamide is predicted to decrease the exposure to
erlotinib. Avoid or adjust erlotinib dose, p. 979.rStudy
▶ Enzalutamide is predicted to decrease the exposure to
esketamine. Adjust dose.oTheoretical
▶ Enzalutamide is predicted to decrease the exposure to
etravirine. Avoid.rTheoretical
▶ Enzalutamide is predicted to decrease the concentration of
everolimus. Avoid or adjust dose.rStudy
▶ Enzalutamide moderately decreases the exposure to
▶ Enzalutamide is predicted to decrease the exposure to
▶ Fibrates (gemfibrozil) moderately increase the exposure to
. Avoid or adjust enzalutamide dose, p. 947.r
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to
fosaprepitant. Avoid.oTheoretical
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to greatly decrease the
concentration of glecaprevir. Avoid.rStudy
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the concentration of
guanfacine. Adjust guanfacine dose, p. 352.oStudy
▶ Enzalutamide decreases the concentration of haloperidol.
▶ Enzalutamide is predicted to decrease the exposure to
ibrutinib. Avoid or adjust ibrutinib dose, p. 983.rStudy
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to
ivabradine. Adjust dose.oTheoretical
▶ Enzalutamide is predicted to moderately to markedly decrease
the exposure to ivacaftor. Avoid.rStudy
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to
lomitapide. Monitor and adjust dose.oTheoretical
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to
midazolam. Monitor and adjust dose.oStudy
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to
mirtazapine. Adjust dose.oStudy
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to markedly decrease the exposure
▶ Enzalutamide is predicted to slightly decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to moderately decrease the
exposure to nilotinib. Avoid.rStudy
▶ Enzalutamide is predicted to decrease the exposure to
nitisinone. Adjust dose.oTheoretical
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to
ombitasvir. Avoid.rTheoretical
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to opioids
▶ Enzalutamide is predicted to decrease the exposure to opioids
(buprenorphine). Monitor and adjust dose.oTheoretical
▶ Enzalutamide decreases the exposure to opioids (methadone).
Monitor and adjust dose.rStudy
▶ Enzalutamide is predicted to decrease the exposure to opioids
(oxycodone). Monitor and adjust dose.oStudy
▶ Enzalutamide is predicted to moderately decrease the
exposure to osimertinib. Avoid.oStudy
▶ Enzalutamide is predicted to moderately decrease the
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to
paliperidone. Monitor and adjust dose.rStudy
▶ Enzalutamide is predicted to decrease the exposure to
panobinostat. Avoid.oTheoretical
▶ Enzalutamide is predicted to decrease the exposure to
(with ritonavir and ombitasvir). Avoid.r
▶ Enzalutamide is predicted to decrease the exposure to
BNF 78 Enzalutamide — Enzalutamide 1451
▶ Enzalutamide is predicted to decrease the exposure to
phosphodiesterase type-5 inhibitors (avanafil, tadalafil). Avoid.
▶ Enzalutamide is predicted to decrease the exposure to
phosphodiesterase type-5 inhibitors (sildenafil, vardenafil).
▶ Enzalutamide is predicted to moderately to markedly decrease
the exposure to pibrentasvir. Avoid.rStudy
▶ Enzalutamide is predicted to moderately decrease the
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to markedly decrease the exposure
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide markedly decreases the exposure to rilpivirine.
▶ Enzalutamide is predicted to decrease the exposure to
risperidone. Adjust dose.oStudy
▶ Enzalutamide is predicted to moderately decrease the
exposure to rivaroxaban. Avoid unless patient can be
monitored for signs of thrombosis.rStudy
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to markedly decrease the exposure
▶ Enzalutamide is predicted to decrease the exposure to
ruxolitinib. Monitor and adjust dose.oStudy
▶ Enzalutamide is predicted to moderately decrease the
exposure to saxagliptin.oStudy
▶ Enzalutamide is predicted to decrease the concentration of
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to statins
▶ Enzalutamide is predicted to decrease the exposure to
sunitinib. Avoid or adjust sunitinib dose, p. 999.oStudy
▶ Enzalutamide decreases the concentration of tacrolimus.
Monitor and adjust dose.rStudy
▶ Enzalutamide is predicted to decrease the exposure to taxanes
(cabazitaxel, paclitaxel). Avoid.rStudy
▶ Enzalutamide is predicted to decrease the exposure to taxanes
▶ Enzalutamide is predicted to decrease the concentration of
▶ Enzalutamide decreases the exposure to tetracyclines
(doxycycline). Monitor and adjust dose.oStudy
▶ Enzalutamide is predicted to decrease the exposure to
tezacaftor. Avoid.rTheoretical
▶ Enzalutamide is predicted to markedly decrease the exposure
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to
. Use with caution or avoid depending on indication.
▶ Enzalutamide is predicted to decrease the exposure to
toremifene. Adjust dose.oStudy
▶ Enzalutamide is predicted to decrease the exposure to
trabectedin. Avoid.rTheoretical
▶ Enzalutamide is predicted to markedly decrease the exposure
rto ulipristal. Avoid and for 4 weeks after stopping ulipristal.
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to moderately decrease the
exposure to velpatasvir. Avoid.rStudy
▶ Enzalutamide is predicted to decrease the exposure to
vemurafenib. Avoid.rTheoretical
▶ Enzalutamide is predicted to decrease the exposure to
▶ Enzalutamide is predicted to decrease the exposure to vinca
alkaloids (vinblastine, vincristine, vindesine).rTheoretical
▶ Enzalutamide is predicted to decrease the exposure to vinca
alkaloids (vinflunine). Avoid.rTheoretical
▶ Enzalutamide is predicted to decrease the exposure to vinca
(vinorelbine). Use with caution or avoid.r
▶ Enzalutamide is predicted to decrease the exposure to
vismodegib. Avoid.oTheoretical
▶ Enzalutamide is predicted to decrease the exposure to
vortioxetine. Monitor and adjust dose.oStudy
▶ Enzalutamide is predicted to decrease the concentration of
▶ Enzalutamide is predicted to decrease the exposure to
Ephedrine → see sympathomimetics, vasoconstrictor
Epirubicin → see anthracyclines
Eplerenone → see aldosterone antagonists
Epoetin alfa → see TABLE 5 p. 1375 (thromboembolism), TABLE 16
p. 1379 (increased serum potassium)
Epoetin beta → see TABLE 5 p. 1375 (thromboembolism), TABLE 16
p. 1379 (increased serum potassium)
Epoetin zeta → see TABLE 5 p. 1375 (thromboembolism), TABLE 16
p. 1379 (increased serum potassium)
Epoprostenol → see TABLE 4 p. 1375 (antiplatelet effects)
Eprosartan → see angiotensin-II receptor antagonists
Eptifibatide → see TABLE 4 p. 1375 (antiplatelet effects)
Ergocalciferol → see vitamin D substances
▶ Antiarrhythmics (dronedarone) are predicted to increase the
risk of ergotism when given with
▶ Antifungals, azoles (fluconazole, isavuconazole, posaconazole)
are predicted to increase the risk of ergotism when given with
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the risk of ergotism when given with
ergometrine. Avoid.rTheoretical
▶ Antifungals, azoles (miconazole) are predicted to increase the
exposure to ergometrine. Avoid.oTheoretical
▶ Aprepitant is predicted to increase the risk of ergotism when
given with ergometrine.rTheoretical
▶ Beta blockers, non-selective are predicted to increase the risk
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