30 gram P £4.32 DT = £3.40 | 100 gram P £12.44 DT = £11.33

Liquid

CAUTIONARY AND ADVISORY LABELS 28

EXCIPIENTS: May contain Propylene glycol

▶ Elocon (Merck Sharp & Dohme Ltd)

Mometasone furoate 1 mg per 1 gram Elocon 0.1% scalp lotion | 30 ml P £4.36 DT = £4.36

CORTICOSTEROIDS › CORTICOSTEROID

COMBINATIONS WITH ANTI-INFECTIVES

Betamethasone with clioquinol 18-Nov-2015

The properties listed below are those particular to the

combination only. For the properties of the components

please consider, betamethasone p. 1243.

l INDICATIONS AND DOSE

Severe inflammatory skin disorders such as eczemas

unresponsive to less potent corticosteroids | Psoriasis

▶ TO THE SKIN

▶ Child: (consult product literature)

▶ Adult: (consult product literature)

POTENCY

▶ Betamethasone (as valerate) 0.1% with clioquinol cream

and ointment: potent.

l UNLICENSED USE

▶ In children Betamethasone and clioquinol preparations is

not licensed for use in children under 1 year.

l INTERACTIONS → Appendix 1: corticosteroids

l PATIENT AND CARER ADVICE Stains clothing. Patients or

carers should be counselled on application of

betamethasone with clioquinol preparations.

l MEDICINAL FORMS There can be variation in the licensing of

different medicines containing the same drug.

Ointment

CAUTIONARY AND ADVISORY LABELS 28

▶ Betamethasone with clioquinol (Non-proprietary)

Betamethasone (as Betamethasone valerate) 1 mg per 1 gram,

Clioquinol 30 mg per 1 gram Betamethasone valerate 0.1% /

Clioquinol 3% ointment | 30 gram P £38.88 DT = £38.88

Cream

CAUTIONARY AND ADVISORY LABELS 28

EXCIPIENTS: May contain Cetostearyl alcohol (including cetyl and

stearyl alcohol), chlorocresol

▶ Betamethasone with clioquinol (Non-proprietary)

Betamethasone (as Betamethasone valerate) 1 mg per 1 gram,

Clioquinol 30 mg per 1 gram Betamethasone valerate 0.1% /

Clioquinol 3% cream | 30 gram P £38.88 DT = £38.88

1248 Inflammatory skin conditions BNF 78

Skin

13

Betamethasone with clotrimazole

The properties listed below are those particular to the

combination only. For the properties of the components

please consider, betamethasone p. 1243, clotrimazole

p. 1232.

l INDICATIONS AND DOSE

Severe inflammatory skin disorders such as eczemas

unresponsive to less potent corticosteroids | Psoriasis

▶ TO THE SKIN

▶ Child: (consult product literature)

▶ Adult: (consult product literature)

POTENCY

▶ Betamethasone dipropionate 0.064% (=betamethasone

0.5%) with clotrimazole cream: potent.

l UNLICENSED USE

▶ In children Lotriderm® not licensed for use in children

under 12 years.

l INTERACTIONS → Appendix 1: antifungals, azoles . corticosteroids

l PATIENT AND CARER ADVICE Patients or carers should be

given advice on how to administer betamethasone with

clotrimazole cream.

l MEDICINAL FORMS There can be variation in the licensing of

different medicines containing the same drug.

Cream

CAUTIONARY AND ADVISORY LABELS 28

EXCIPIENTS: May contain Benzyl alcohol, cetostearyl alcohol (including

cetyl and stearyl alcohol), propylene glycol

▶ Lotriderm (Merck Sharp & Dohme Ltd)

Betamethasone dipropionate 640 microgram per 1 gram,

Clotrimazole 10 mg per 1 gram Lotriderm cream | 30 gram P £6.34 DT = £6.34

Betamethasone with fusidic acid

The properties listed below are those particular to the

combination only. For the properties of the components

please consider, betamethasone p. 1243, fusidic acid p. 571.

l INDICATIONS AND DOSE

Severe inflammatory skin disorders such as eczemas

unresponsive to less potent corticosteroids | Psoriasis

▶ TO THE SKIN

▶ Child: (consult product literature)

▶ Adult: (consult product literature)

POTENCY

▶ Betamethasone (as valerate) 0.1% with fusidic acid

cream: potent.

l UNLICENSED USE

▶ In children Fucibet ® Lipid Cream is not licensed for use in

children under 6 years.

l INTERACTIONS → Appendix 1: corticosteroids . fusidic acid

l PATIENT AND CARER ADVICE Patients or carers should be

counselled on application of betamethasone with fusidic

acid preparations.

l MEDICINAL FORMS There can be variation in the licensing of

different medicines containing the same drug.

Cream

CAUTIONARY AND ADVISORY LABELS 28

EXCIPIENTS: May contain Cetostearyl alcohol (including cetyl and

stearyl alcohol), chlorocresol, hydroxybenzoates (parabens)

▶ Fucibet (LEO Pharma)

Betamethasone (as Betamethasone valerate) 1 mg per 1 gram,

Fusidic acid 20 mg per 1 gram Fucibet cream | 30 gram P £6.38 DT = £6.38 | 60 gram P £12.76 DT = £12.76

Fucibet Lipid cream | 30 gram P £6.74 DT = £6.38

▶ Xemacort (Mylan)

Betamethasone (as Betamethasone valerate) 1 mg per 1 gram,

Fusidic acid 20 mg per 1 gram Xemacort cream | 30 gram P £6.05 DT = £6.38 | 60 gram P £12.45 DT = £12.76

Betamethasone with neomycin

The properties listed below are those particular to the

combination only. For the properties of the components

please consider, betamethasone p. 1243, neomycin sulfate

p. 1230.

l INDICATIONS AND DOSE

Severe inflammatory skin disorders such as eczemas

unresponsive to less potent corticosteroids | Psoriasis

▶ TO THE SKIN USING OINTMENT, OR TO THE SKIN USING CREAM

▶ Child 2–17 years: Apply 1–2 times a day, to be applied

thinly

▶ Adult: Apply 1–2 times a day, to be applied thinly

POTENCY

▶ Betamethasone (as valerate) 0.1% with neomycin cream

and ointment: potent.

l INTERACTIONS → Appendix 1: corticosteroids . neomycin

l PATIENT AND CARER ADVICE Patient counselling is advised

for betamethasone with neomycin cream and ointment

(application).

l MEDICINAL FORMS There can be variation in the licensing of

different medicines containing the same drug.

Ointment

CAUTIONARY AND ADVISORY LABELS 28

▶ Betamethasone with neomycin (Non-proprietary)

Betamethasone (as Betamethasone valerate) 1 mg per 1 gram,

Neomycin sulfate 5 mg per 1 gram Betamethasone valerate 0.1% /

Neomycin 0.5% ointment | 30 gram P £38.88 DT = £31.36 | 100 gram P £97.00 DT = £104.52

Cream

CAUTIONARY AND ADVISORY LABELS 28

EXCIPIENTS: May contain Cetostearyl alcohol (including cetyl and

stearyl alcohol), chlorocresol

▶ Betamethasone with neomycin (Non-proprietary)

Betamethasone (as Betamethasone valerate) 1 mg per 1 gram,

Neomycin sulfate 5 mg per 1 gram Betamethasone valerate 0.1% /

Neomycin 0.5% cream | 30 gram P £38.88 DT = £31.36 | 100 gram P £97.00 DT = £104.52

Betamethasone with salicylic acid

The properties listed below are those particular to the

combination only. For the properties of the components

please consider, betamethasone p. 1243, salicylic acid

p. 1286.

l INDICATIONS AND DOSE

DIPROSALIC ® OINTMENT

Severe inflammatory skin disorders such as eczemas

unresponsive to less potent corticosteroids | Psoriasis

▶ TO THE SKIN

▶ Child: Apply 1–2 times a day, max. 60 g per week

▶ Adult: Apply 1–2 times a day, max. 60 g per week

POTENCY

▶ Betamethasone (as dipropionate) 0.05% with salicylic

acid 3%: potent.

DIPROSALIC ® SCALP APPLICATION

Severe inflammatory skin disorders such as eczemas

unresponsive to less potent corticosteroids | Psoriasis

▶ TO THE SKIN

▶ Child: Apply 1–2 times a day, apply a few drops

▶ Adult: Apply 1–2 times a day, apply a few drops

continued→

BNF 78 Eczema and psoriasis 1249

Skin

13

POTENCY

▶ Betamethasone (as dipropionate) 0.05% with salicylic

acid 2%: potent.

l INTERACTIONS → Appendix 1: corticosteroids

l PATIENT AND CARER ADVICE

DIPROSALIC ® OINTMENT Patients or carers should be

counselled on application of betamethasone and salicylic

acid preparations.

DIPROSALIC ® SCALP APPLICATION Patients or carers

should be counselled on application of betamethasone and

salicylic acid scalp application.

l MEDICINAL FORMS There can be variation in the licensing of

different medicines containing the same drug.

Ointment

CAUTIONARY AND ADVISORY LABELS 28

▶ Diprosalic (Merck Sharp & Dohme Ltd)

Betamethasone (as Betamethasone dipropionate)

500 microgram per 1 gram, Salicylic acid 30 mg per

1 gram Diprosalic 0.05%/3% ointment | 30 gram P £3.18 DT =

£3.18 | 100 gram P £9.14 DT = £9.14

Liquid

CAUTIONARY AND ADVISORY LABELS 28

EXCIPIENTS: May contain Disodium edetate

▶ Diprosalic (Merck Sharp & Dohme Ltd)

Betamethasone (as Betamethasone dipropionate)

500 microgram per 1 ml, Salicylic acid 20 mg per 1 ml Diprosalic

0.05%/2% scalp application | 100 ml P £10.10 DT = £10.10

Clobetasol propionate with neomycin

sulfate and nystatin

The properties listed below are those particular to the

combination only. For the properties of the components

please consider, clobetasol propionate p. 1244, neomycin

sulfate p. 1230.

l INDICATIONS AND DOSE

Short-term treatment only of severe resistant

inflammatory skin disorders such as recalcitrant

eczemas associated with infection and unresponsive to

less potent corticosteroids | Psoriasis associated with

infection

▶ TO THE SKIN

▶ Adult: (consult product literature)

POTENCY

▶ Clobetasol propionate 0.05% with neomycin sulfate and

nystatin cream and ointment: very potent.

l INTERACTIONS → Appendix 1: neomycin

l PATIENT AND CARER ADVICE Patients or carers should be

advised on application of clobetasol propionate, neomycin

sulfate and nystatin containing preparations.

l MEDICINAL FORMS There can be variation in the licensing of

different medicines containing the same drug.

Ointment

CAUTIONARY AND ADVISORY LABELS 28

▶ Clobetasol propionate with neomycin sulfate and nystatin (Nonproprietary)

Clobetasol propionate 500 microgram per 1 gram, Neomycin

sulfate 5 mg per 1 gram, Nystatin 100000 unit per

1 gram Clobetasol 500microgram / Neomycin 5mg / Nystatin

100,000units/g ointment | 30 gram P £87.00 DT = £87.00

Cream

CAUTIONARY AND ADVISORY LABELS 28

▶ Clobetasol propionate with neomycin sulfate and nystatin (Nonproprietary)

Clobetasol propionate 500 microgram per 1 gram, Neomycin

sulfate 5 mg per 1 gram, Nystatin 100000 unit per

1 gram Clobetasol 500microgram / Neomycin 5mg / Nystatin

100,000units/g cream | 30 gram P £87.00 DT = £87.00

Clobetasone butyrate with nystatin

and oxytetracycline

The properties listed below are those particular to the

combination only. For the properties of the components

please consider, clobetasone butyrate p. 1245,

oxytetracycline p. 567.

l INDICATIONS AND DOSE

Steroid-responsive dermatoses where candidal or

bacterial infection is present

▶ TO THE SKIN

▶ Adult: (consult product literature)

POTENCY

▶ Clobetasone butyrate 0.05% with nystatin and

oxytetracyline cream: moderate.

l INTERACTIONS → Appendix 1: tetracyclines

l PATIENT AND CARER ADVICE Stains clothing.

l MEDICINAL FORMS There can be variation in the licensing of

different medicines containing the same drug. Forms available

from special-order manufacturers include: cream

Cream

CAUTIONARY AND ADVISORY LABELS 28

EXCIPIENTS: May contain Cetostearyl alcohol (including cetyl and

stearyl alcohol), chlorocresol, sodium metabisulfite

▶ Trimovate (Ennogen Healthcare Ltd)

Clobetasone butyrate 500 microgram per 1 gram,

Oxytetracycline (as Oxytetracycline calcium) 30 mg per 1 gram,

Nystatin 100000 unit per 1 gram Trimovate cream | 30 gram P £12.45 DT = £12.45

Fluocinolone acetonide with clioquinol

The properties listed below are those particular to the

combination only. For the properties of the components

please consider, fluocinolone acetonide p. 1246.

l INDICATIONS AND DOSE

Inflammatory skin disorders such as eczemas associated

with infection | Psoriasis associated with infection

▶ TO THE SKIN

▶ Adult: Apply 1–2 times a day, to be applied thinly,

reducing strength as condition responds

POTENCY

▶ Clioquinol 3% with fluocinolone acetonide 0.025%

cream and ointment: potent

l INTERACTIONS → Appendix 1: fluocinolone

l PATIENT AND CARER ADVICE Patient counselling is advised

for clioquinol with fluocinolone acetonide cream and

ointment (application). Ointment stains clothing.

l MEDICINAL FORMS There can be variation in the licensing of

different medicines containing the same drug.

Ointment

CAUTIONARY AND ADVISORY LABELS 28

EXCIPIENTS: May contain Propylene glycol, woolfat and related

substances (including lanolin)

▶ Synalar C (Reig Jofre UK Ltd)

Fluocinolone acetonide 250 microgram per 1 gram, Clioquinol

30 mg per 1 gram Synalar C ointment | 15 gram P £2.66 DT =

£2.66

Cream

CAUTIONARY AND ADVISORY LABELS 28

EXCIPIENTS: May contain Cetostearyl alcohol (including cetyl and

stearyl alcohol), disodium edetate, hydroxybenzoates (parabens),

polysorbates, propylene glycol

▶ Synalar C (Reig Jofre UK Ltd)

Fluocinolone acetonide 250 microgram per 1 gram, Clioquinol

30 mg per 1 gram Synalar C cream | 15 gram P £2.66 DT =

£2.66

1250 Inflammatory skin conditions BNF 78

Skin

13

Fluocinolone acetonide with neomycin

The properties listed below are those particular to the

combination only. For the properties of the components

please consider, fluocinolone acetonide p. 1246, neomycin

sulfate p. 1230.

l INDICATIONS AND DOSE

Inflammatory skin disorders such as eczemas associated

with infection | Psoriasis associated with infection

▶ TO THE SKIN

▶ Child 1–17 years: Apply 1–2 times a day, to be applied

thinly, reducing strength as condition responds

▶ Adult: Apply 1–2 times a day, to be applied thinly,

reducing strength as condition responds

POTENCY

▶ Fluocinolone acetonide 0.025% with neomycin 0.5%

cream and ointment: potent.

l INTERACTIONS → Appendix 1: fluocinolone . neomycin

l PATIENT AND CARER ADVICE Patients or carers should be

counselled on the application of fluocinolone acetonide

with neomycin preparations.

l MEDICINAL FORMS There can be variation in the licensing of

different medicines containing the same drug.

Ointment

CAUTIONARY AND ADVISORY LABELS 28

EXCIPIENTS: May contain Propylene glycol, woolfat and related

substances (including lanolin)

▶ Synalar N (Reig Jofre UK Ltd)

Fluocinolone acetonide 250 microgram per 1 gram, Neomycin

sulfate 5 mg per 1 gram Synalar N ointment | 30 gram P £4.36

Hydrocortisone with benzalkonium

chloride, dimeticone and nystatin

15-Mar-2016

The properties listed below are those particular to the

combination only. For the properties of the components

please consider, hydrocortisone p. 1247, dimeticone p. 1236.

l INDICATIONS AND DOSE

Mild inflammatory skin disorders such as eczemas

associated with infection

▶ TO THE SKIN

▶ Child: Apply 3 times a day until lesion has healed, to be

applied thinly

▶ Adult: Apply 3 times a day until lesion has healed, to be

applied thinly

POTENCY

▶ Benzalkonium with dimeticone, hydrocortisone acetate

0.5%, and nystatin cream: mild.

l INTERACTIONS → Appendix 1: corticosteroids

l PATIENT AND CARER ADVICE Patients or carers should be

advised on application of benzalkonium with dimeticone

and hydrocortisone and nystatin preparations.

l MEDICINAL FORMS There can be variation in the licensing of

different medicines containing the same drug.

Cream

CAUTIONARY AND ADVISORY LABELS 28

EXCIPIENTS: May contain Butylated hydroxyanisole, cetostearyl alcohol

(including cetyl and stearyl alcohol), hydroxybenzoates (parabens),

sodium metabisulfite, sorbic acid

▶ Timodine (Alliance Pharmaceuticals Ltd)

Benzalkonium chloride 1 mg per 1 gram, Hydrocortisone 5 mg per

1 gram, Dimeticone 350 100 mg per 1 gram, Nystatin

100000 unit per 1 gram Timodine cream | 30 gram P £3.37

Hydrocortisone with chlorhexidine

hydrochloride and nystatin

The properties listed below are those particular to the

combination only. For the properties of the components

please consider, hydrocortisone p. 1247, chlorhexidine

p. 1277.

l INDICATIONS AND DOSE

Mild inflammatory skin disorders such as eczemas

▶ TO THE SKIN

▶ Child: To be applied thinly (consult product literature)

▶ Adult: To be applied thinly (consult product literature)

POTENCY

▶ Hydrocortisone 0.5% with chlorhexidine hydrochloride

1% and nystatin cream: mild

▶ Hydrocortisone 1% with chlorhexidine hydrochloride 1%

and nystatin ointment: mild

l INTERACTIONS → Appendix 1: corticosteroids

l PATIENT AND CARER ADVICE Patients or carers should be

given advice on application of chlorhexidine hydrochloride

with hydrocortisone and nystatin preparations.

l MEDICINAL FORMS There can be variation in the licensing of

different medicines containing the same drug.

Ointment

CAUTIONARY AND ADVISORY LABELS 28

▶ Hydrocortisone with chlorhexidine hydrochloride and nystatin

(Non-proprietary)

Chlorhexidine acetate 10 mg per 1 gram, Hydrocortisone 10 mg

per 1 gram, Nystatin 100000 unit per 1 gram Nystatin

100,000units/g / Chlorhexidine acetate 1% / Hydrocortisone 1%

ointment | 30 gram P £5.29 DT = £5.29

Cream

CAUTIONARY AND ADVISORY LABELS 28

EXCIPIENTS: May contain Benzyl alcohol, cetostearyl alcohol (including

cetyl and stearyl alcohol), polysorbates

▶ Hydrocortisone with chlorhexidine hydrochloride and nystatin

(Non-proprietary)

Hydrocortisone 5 mg per 1 gram, Chlorhexidine hydrochloride

10 mg per 1 gram, Nystatin 100000 unit per 1 gram Nystatin

100,000units/g / Chlorhexidine hydrochloride 1% / Hydrocortisone

0.5% cream | 30 gram P £5.29 DT = £5.29

Hydrocortisone with clotrimazole

The properties listed below are those particular to the

combination only. For the properties of the components

please consider, hydrocortisone p. 1247, clotrimazole

p. 1232.

l INDICATIONS AND DOSE

Mild inflammatory skin disorders such as eczemas

(associated with fungal infection)

▶ TO THE SKIN

▶ Child: (consult product literature)

▶ Adult: (consult product literature)

POTENCY

▶ Clotrimazole with hydrocortisone 1% cream: mild

l INTERACTIONS → Appendix 1: antifungals, azoles . corticosteroids

l PATIENT AND CARER ADVICE Patients or carers should be

given advice on how to administer clotrimazole with

hydrocortisone cream.

l EXCEPTIONS TO LEGAL CATEGORY A 15-g tube is on sale to

the public for the treatment of athlete’s foot and fungal

infection of skin folds with associated inflammation in

patients 10 years and over.

BNF 78 Eczema and psoriasis 1251

Skin

13

l MEDICINAL FORMS There can be variation in the licensing of

different medicines containing the same drug.

Cream

CAUTIONARY AND ADVISORY LABELS 28

EXCIPIENTS: May contain Benzyl alcohol, cetostearyl alcohol (including

cetyl and stearyl alcohol)

▶ Canesten HC (Bayer Plc)

Clotrimazole 10 mg per 1 gram, Hydrocortisone 10 mg per

1 gram Canesten HC cream | 30 gram P £2.42 DT = £2.42

Hydrocortisone with fusidic acid

The properties listed below are those particular to the

combination only. For the properties of the components

please consider, hydrocortisone p. 1247, fusidic acid p. 571.

l INDICATIONS AND DOSE

Mild inflammatory skin disorders such as eczemas

▶ TO THE SKIN

▶ Child: To be applied thinly (consult product literature)

▶ Adult: To be applied thinly (consult product literature)

POTENCY

▶ Hydrocortisone with fusidic acid cream: mild

l INTERACTIONS → Appendix 1: corticosteroids . fusidic acid

l PATIENT AND CARER ADVICE Patients or carers should be

advised on application of hydrocortisone with fusidic acid

preparations.

l MEDICINAL FORMS There can be variation in the licensing of

different medicines containing the same drug.

Cream

CAUTIONARY AND ADVISORY LABELS 28

EXCIPIENTS: May contain Butylated hydroxyanisole, cetostearyl alcohol

(including cetyl and stearyl alcohol), polysorbates, potassium sorbate

▶ Fucidin H (Fusidic acid / Hydrocortisone) (LEO Pharma)

Hydrocortisone acetate 10 mg per 1 gram, Fusidic acid 20 mg per

1 gram Fucidin H cream | 30 gram P £6.02 DT = £6.02 | 60 gram P £12.05 DT = £12.05

Hydrocortisone with miconazole

The properties listed below are those particular to the

combination only. For the properties of the components

please consider, hydrocortisone p. 1247, miconazole p. 1233.

l INDICATIONS AND DOSE

Mild inflammatory skin disorders such as eczemas

associated with infections

▶ TO THE SKIN

▶ Adult: (consult product literature)

POTENCY

▶ Hydrocortisone 1% with miconazole cream and

ointment: mild

l INTERACTIONS → Appendix 1: antifungals, azoles . corticosteroids

l PATIENT AND CARER ADVICE Patients or carers should be

advised on application of hydrocortisone with miconazole

preparations.

l PROFESSION SPECIFIC INFORMATION

Dental practitioners’ formulary

May be prescribed as Miconazole and Hydrocortisone

Cream or Ointment for max. 7 days.

l EXCEPTIONS TO LEGAL CATEGORY A 15-g tube of

hydrocortisone with miconazole cream is on sale to the

public for the treatment of athlete’s foot and candidal

intertrigo.

l MEDICINAL FORMS There can be variation in the licensing of

different medicines containing the same drug.

Ointment

CAUTIONARY AND ADVISORY LABELS 28

▶ Daktacort (Janssen-Cilag Ltd)

Hydrocortisone 10 mg per 1 gram, Miconazole nitrate 20 mg per

1 gram Daktacort ointment | 30 gram P £2.50 DT = £2.50

Cream

CAUTIONARY AND ADVISORY LABELS 28

EXCIPIENTS: May contain Butylated hydroxyanisole, disodium edetate

▶ Daktacort (McNeil Products Ltd, Janssen-Cilag Ltd)

Hydrocortisone 10 mg per 1 gram, Miconazole nitrate 20 mg per

1 gram Daktacort 2%/1% cream | 30 gram P £2.49 DT = £2.49

Hydrocortisone with oxytetracycline

The properties listed below are those particular to the

combination only. For the properties of the components

please consider, hydrocortisone p. 1247, oxytetracycline

p. 567.

l INDICATIONS AND DOSE

Mild inflammatory skin disorders such as eczemas

▶ TO THE SKIN

▶ Child 12–17 years: (consult product literature)

▶ Adult: (consult product literature)

POTENCY

▶ Hydrocortisone 1% with oxytetracycline ointment: mild.

l CONTRA-INDICATIONS Children under 12 years

l INTERACTIONS → Appendix 1: corticosteroids . tetracyclines

l PREGNANCY Tetracyclines should not be given to pregnant

women. Effects on skeletal development have been

documented when tetracyclines have been used in the first

trimester in animal studies. Administration during the

second or third trimester may cause discoloration of the

child’s teeth.

l BREAST FEEDING Tetracyclines should not be given to

women who are breast-feeding (although absorption and

therefore discoloration of teeth in the infant is probably

usually prevented by chelation with calcium in milk).

l PATIENT AND CARER ADVICE Patients should be given

advice on the application of hydrocortisone with

oxytetracycline ointment.

l MEDICINAL FORMS There can be variation in the licensing of

different medicines containing the same drug.

Ointment

CAUTIONARY AND ADVISORY LABELS 28

▶ Terra-Cortril (Intrapharm Laboratories Ltd)

Hydrocortisone 10 mg per 1 gram, Oxytetracycline (as

Oxytetracycline hydrochloride) 30 mg per 1 gram Terra-Cortril

ointment | 30 gram P £5.01 DT = £5.01

DERMATOLOGICAL DRUGS › ANTI-INFECTIVES

Ichthammol

l INDICATIONS AND DOSE

Chronic lichenified eczema

▶ TO THE SKIN

▶ Child 1–17 years: Apply 1–3 times a day

▶ Adult: Apply 1–3 times a day

l UNLICENSED USE

▶ In children No information available.

l SIDE-EFFECTS Skin irritation

1252 Inflammatory skin conditions BNF 78

Skin

13

l MEDICINAL FORMS There can be variation in the licensing of

different medicines containing the same drug. Forms available

from special-order manufacturers include: ointment, paste

Liquid

▶ Ichthammol (Non-proprietary)

Ichthammol 1 mg per 1 mg Ichthammol liquid | 100 gram G £12.86 DT = £12.86 | 500 gram G £41.47

Ichthammol with zinc oxide

The properties listed below are those particular to the

combination only. For the properties of the components

please consider, ichthammol p. 1252.

l INDICATIONS AND DOSE

Chronic lichenified eczema

▶ TO THE SKIN

▶ Adult: (consult product literature)

l MEDICINAL FORMS There can be variation in the licensing of

different medicines containing the same drug. Forms available

from special-order manufacturers include: cream, ointment

Impregnated dressing

▶ Ichthopaste (Evolan Pharma AB)

Ichthopaste bandage 7.5cm 6 6m | 1 bandage £3.78

DERMATOLOGICAL DRUGS › ANTRACEN

DERIVATIVES

Dithranol

(Anthralin)

l INDICATIONS AND DOSE

Subacute and chronic psoriasis

▶ TO THE SKIN

▶ Adult: (consult product literature)

DITHROCREAM ®

Subacute and chronic psoriasis

▶ TO THE SKIN

▶ Adult: For application to skin or scalp, 0.1–0.5% cream

suitable for overnight treatment, 1–2% cream for

maximum 1 hour (consult product literature)

MICANOL ®

Subacute and chronic psoriasis

▶ TO THE SKIN

▶ Adult: Apply once daily, for application to skin or scalp,

to be applied for up to 30 minutes, apply 1% cream, if

necessary 3% cream can be used under medical

supervision

l CONTRA-INDICATIONS Acute and pustular psoriasis . hypersensitivity

l CAUTIONS Avoid sensitive areas of skin . avoid use near

eyes

l SIDE-EFFECTS Skin reactions

l PREGNANCY No adverse effects reported.

l BREAST FEEDING No adverse effects reported.

l DIRECTIONS FOR ADMINISTRATION When applying

dithranol, hands should be protected by gloves or they

should be washed thoroughly afterwards. Dithranol should

be applied to chronic extensor plaques only, carefully

avoiding normal skin.

MICANOL ® At the end of contact time, use plenty of

lukewarm (not hot) water to rinse off cream; soap may be

used after the cream has been rinsed off; use shampoo

before applying cream to scalp and if necessary after cream

has been rinsed off.

l PRESCRIBING AND DISPENSING INFORMATION Treatment

should be started with a low concentration such as

dithranol 0.1%, and the strength increased gradually every

few days up to 3%, according to tolerance.

l PATIENT AND CARER ADVICE Dithranol can stain the skin,

hair and fabrics.

l EXCEPTIONS TO LEGAL CATEGORY Prescription only

medicine if dithranol content more than 1%, otherwise

may be sold to the public.

l MEDICINAL FORMS There can be variation in the licensing of

different medicines containing the same drug. Forms available

from special-order manufacturers include: ointment

Cream

CAUTIONARY AND ADVISORY LABELS 28

EXCIPIENTS: May contain Cetostearyl alcohol (including cetyl and

stearyl alcohol), chlorocresol

▶ Dithrocream (Dermal Laboratories Ltd)

Dithranol 1 mg per 1 gram Dithrocream 0.1% cream | 50 gram p

£3.77 DT = £3.77

Dithranol 2.5 mg per 1 gram Dithrocream 0.25% cream | 50 gram p £4.04 DT = £4.04

Dithranol 5 mg per 1 gram Dithrocream 0.5% cream | 50 gram p

£4.66 DT = £4.66

Dithranol 10 mg per 1 gram Dithrocream 1% cream | 50 gram p

£5.42 DT = £5.42

Dithranol 20 mg per 1 gram Dithrocream 2% cream | 50 gram P £6.79 DT = £6.79

Combinations available: Coal tar with dithranol and salicylic

acid, p. 1254

Dithranol with salicylic acid and zinc

oxide

The properties listed below are those particular to the

combination only. For the properties of the components

please consider, dithranol above, salicylic acid p. 1286.

l INDICATIONS AND DOSE

Subacute and chronic psoriasis

▶ TO THE SKIN

▶ Adult: (consult local protocol)

l MEDICINAL FORMS Forms available from special-order

manufacturers include: ointment, paste

DERMATOLOGICAL DRUGS › TARS

Coal tar

l INDICATIONS AND DOSE

Psoriasis | Chronic atopic eczema

▶ TO THE SKIN USING PASTE

▶ Child: Apply 1–3 times a day, start application with

low-strength preparations

▶ Adult: Apply 1–3 times a day, start application with

low-strength preparations

▶ TO THE SKIN

▶ Child: 100 mL/bath, to be added to an adult sized bath;

add proportionally less for a child’s bath. Use Coal Tar

Solution BP

▶ Adult: 100 mL/bath, to be added to an adult sized bath.

Use Coal Tar Solution BP

ALPHOSYL 2 IN 1 ® SHAMPOO

Psoriasis | Seborrhoeic dermatitis | Scaling | Itching

▶ TO THE SKIN

▶ Adult: Apply every 2–3 days

Dandruff

▶ TO THE SKIN

▶ Adult: Apply 1–2 times a week as required continued→

BNF 78 Eczema and psoriasis 1253

Skin

13

EXOREX ® LOTION

Psoriasis

▶ TO THE SKIN

▶ Adult: Apply 2–3 times a day, to be applied to skin or

scalp; in elderly, lotion can be diluted with a few drops

of water before applying

PSORIDERM ® SCALP LOTION

Scalp psoriasis

▶ TO THE SKIN

▶ Child: Apply as required

▶ Adult: Apply as required

l CONTRA-INDICATIONS Avoid broken or inflamed skin . avoid eye area . avoid genital area . avoid mucosal areas . avoid rectal area . infection . sore, acute, or pustular

psoriasis

l CAUTIONS Application to face . application to skin flexures

l SIDE-EFFECTS Photosensitivity reaction . skin reactions

l PRESCRIBING AND DISPENSING INFORMATION Coal Tar

Solution BP contains coal tar 20%, Strong Coal Tar

Solution BP contains coal tar 40%.

l HANDLING AND STORAGE Use suitable chemical protection

gloves for extemporaneous preparation. May stain skin,

hair and fabric.

l PATIENT AND CARER ADVICE May stain skin, hair and

fabric.

l MEDICINAL FORMS There can be variation in the licensing of

different medicines containing the same drug. Forms available

from special-order manufacturers include: cream, ointment,

paste

Cutaneous emulsion

EXCIPIENTS: May contain Hydroxybenzoates (parabens)

▶ Exorex (Teva UK Ltd)

Coal tar solution 50 mg per 1 gram Exorex lotion | 100 ml G £8.11 DT = £8.11 | 250 ml G £16.24 DT = £16.24

Shampoo

EXCIPIENTS: May contain Fragrances, hydroxybenzoates (parabens)

▶ Alphosyl 2 in 1 (Omega Pharma Ltd)

Coal tar extract alcoholic 50 mg per 1 gram Alphosyl 2 in 1

shampoo | 250 ml G £5.49 DT = £5.49

▶ Neutrogena T/Gel Therapeutic (Johnson & Johnson Ltd)

Coal tar extract 20 mg per 1 gram Neutrogena T/Gel Therapeutic

shampoo | 125 ml G £3.90 DT = £3.90 | 250 ml G £5.86 DT =

£5.86

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