▶ Miconazole is predicted to increase the concentration of
predicted to increase the exposure to
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the exposure to
repaglinide.o ▶ Antifungals, azoles (fluconazole, itraconazole, ketoconazole,
miconazole, voriconazole) are predicted to increase the
exposure to retinoids (alitretinoin). Adjust alitretinoin dose,
▶ Antifungals, azoles (fluconazole, ketoconazole, voriconazole) are
predicted to increase the risk of tretinoin toxicity when given
with retinoids (tretinoin).oStudy
▶ Antifungals, azoles (fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure to
Study → Also see TABLE 9 p. 1377
ribociclib.o ▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the exposure to ribociclib. Avoid or
adjust ribociclib dose, p. 997.oStudy → Also see TABLE 9
▶ Antifungals, azoles (itraconazole, posaconazole) increase the
concentration of rifabutin and rifabutin decreases the
concentration of antifungals, azoles (itraconazole,
▶ Fluconazole increases the risk of uveitis when given with
▶ Rifabutin is predicted to decrease the exposure to
isavuconazole. Avoid.rTheoretical
▶ Ketoconazole is predicted to increase the concentration of
rifabutin and rifabutin is predicted to decrease the
concentration of ketoconazole. Avoid.rTheoretical
▶ Miconazole is predicted to increase the concentration of
. Use with caution and adjust dose.o ▶ Rifabutin decreases the concentration of voriconazole and
voriconazole increases the concentration of rifabutin. Avoid or
adjust voriconazole dose, p. 599.rStudy
▶ Rifampicin slightly decreases the exposure to fluconazole.
▶ Rifampicin is predicted to decrease the exposure to
▶ Rifampicin markedly decreases the exposure to itraconazole.
Avoid and for 14 days after stopping rifampicin.oStudy
▶ Rifampicin markedly decreases the exposure to ketoconazole
and ketoconazole potentially decreases the exposure to
▶ Rifampicin is predicted to decrease the exposure to
posaconazole. Avoid.oAnecdotal
▶ Rifampicin very markedly decreases the exposure to
▶ Itraconazole is predicted to increase the exposure to riociguat.
▶ Ketoconazole moderately increases the exposure to riociguat.
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the exposure to
Study → Also see TABLE 9 p. 1377
▶ Antifungals, azoles (itraconazole, ketoconazole) are predicted to
moderately increase the exposure to
▶ Antifungals, azoles (fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure to
ruxolitinib.o ▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the exposure to ruxolitinib. Adjust dose
and monitor side effects.oStudy
▶ Antifungals, azoles (fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure to saxagliptin.n
BNF 78 Antifungals, azoles — Antifungals, azoles 1405
Antifungals, azoles (continued)
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the exposure to
is predicted to increase the exposure to selexipag.
▶ Antifungals, azoles (fluconazole, isavuconazole, posaconazole)
increase the concentration of sirolimus. Monitor and adjust
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the concentration of
▶ Miconazole is predicted to increase the concentration of
sirolimus. Monitor and adjust dose.oStudy
▶ Oral sodium bicarbonate decreases the absorption of
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the exposure to solifenacin. Adjust
solifenacin p. 779 or tamsulosin with solifenacin p. 786 dose;
avoid in hepatic and renal impairment.rStudy
▶ Voriconazole is predicted to increase the exposure to SSRIs
(citalopram).rTheoretical → Also see TABLE 9 p. 1377
▶ Antifungals, azoles (fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure to SSRIs (dapoxetine).
Adjust dapoxetine dose with moderate inhibitors of CYP3A4,
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to moderately increase the exposure to SSRIs
(dapoxetine). Avoid potent inhibitors of CYP3A4 or adjust
dapoxetine dose, p. 821.rStudy
▶ St John’s Wort is predicted to decrease the exposure to
isavuconazole. Avoid.rTheoretical
▶ St John’s Wort moderately decreases the exposure to
▶ Miconazole potentially increases the exposure to statins
▶ Antifungals, azoles (fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure to statins (atorvastatin).
Monitor and adjust dose.rStudy → Also see TABLE 1 p. 1375
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the exposure to statins (atorvastatin).
Avoid or adjust dose and monitor rhabdomyolysis.
Study → Also see TABLE 1 p. 1375
▶ Antifungals, azoles (fluconazole, miconazole) are predicted to
Theoretical → Also see TABLE 1
▶ Isavuconazole is predicted to increase the exposure to statins
(fluvastatin, rosuvastatin).oTheoretical
▶ Miconazole is predicted to increase the exposure to statins
(simvastatin). Avoid.rTheoretical
▶ Antifungals, azoles (fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure to statins (simvastatin).
Study → Also see TABLE 1 p. 1375
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the exposure to statins (simvastatin).
Avoid.rStudy → Also see TABLE 1 p. 1375
▶ Isavuconazole is predicted to increase the exposure to
▶ Antifungals, azoles (fluconazole, miconazole) are predicted to
increase the exposure to sulfonylureas. Use with caution and
▶ Voriconazole is predicted to increase the concentration of
are predicted to increase the exposure to
Theoretical → Also see TABLE 9 p. 1377
sunitinib.o ▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to slightly increase the exposure to sunitinib. Avoid
or adjust sunitinib dose, p. 999.oStudy → Also see TABLE 9
▶ Antifungals, azoles (fluconazole, isavuconazole, posaconazole)
are predicted to increase the concentration of
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the concentration of tacrolimus. Monitor
▶ Miconazole is predicted to increase the concentration of
tacrolimus. Monitor and adjust dose.rTheoretical
▶ Antifungals, azoles (fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure to
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the exposure to taxanes (cabazitaxel).
▶ Miconazole is predicted to increase the concentration of
(docetaxel). Use with caution and adjust dose.
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to moderately increase the exposure to taxanes
(docetaxel). Avoid or adjust dose.rStudy
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the exposure to
▶ Antifungals, azoles (fluconazole, isavuconazole, posaconazole)
are predicted to increase the concentration of
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the concentration of temsirolimus.
▶ Antifungals, azoles (fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure to tezacaftor. Adjust
tezacaftor with ivacaftor p. 295 dose with moderate inhibitors
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the exposure to tezacaftor. Adjust
tezacaftor with ivacaftor p. 295 dose with potent inhibitors of
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to markedly increase the exposure to ticagrelor.
▶ Antifungals, azoles (fluconazole, isavuconazole, posaconazole)
given with a potent CYP2C19 inhibitor are predicted to
increase the exposure to tofacitinib. Adjust tofacitinib dose,
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the exposure to tofacitinib. Adjust
tofacitinib dose, p. 1105.oStudy
▶ Antifungals, azoles (fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure to tolterodine.n Theoretical → Also see TABLE 9 p. 1377
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the exposure to
Study → Also see TABLE 9 p. 1377
▶ Antifungals, azoles (fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure to tolvaptan.
Manufacturer advises caution or adjust tolvaptan dose with
moderate inhibitors of CYP3A4, p. 669.oStudy
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the exposure to tolvaptan. Manufacturer
advises caution or adjust tolvaptan dose with potent inhibitors
▶ Antifungals, azoles (itraconazole, ketoconazole) are predicted to
increase the exposure to topotecan.rStudy
▶ Isavuconazole is predicted to increase the exposure to
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the exposure to
Theoretical → Also see TABLE 9 p. 1377
toremifene.o ▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the exposure to trabectedin. Avoid or
adjust dose.rTheoretical → Also see TABLE 1 p. 1375
▶ Antifungals, azoles (itraconazole, ketoconazole) are predicted to
increase the concentration of trametinib.oTheoretical
▶ Antifungals, azoles (fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure to
1406 Antifungals, azoles — Antifungals, azoles BNF 78
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to moderately increase the exposure to trazodone.
▶ Antifungals, azoles (fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure to ulipristal. Avoid if
used for uterine fibroids.oStudy
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the exposure to ulipristal. Avoid if used
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the exposure to
Theoretical → Also see TABLE 9 p. 1377
▶ Antifungals, azoles (fluconazole, isavuconazole, itraconazole,
ketoconazole, posaconazole, voriconazole) are predicted to
increase the exposure to venetoclax. Avoid or adjust dose—
consult product literature.rStudy
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the exposure to
Study → Also see TABLE 9 p. 1377
venlafaxine.o ▶ Antifungals, azoles (fluconazole, isavuconazole, itraconazole,
ketoconazole, posaconazole, voriconazole) are predicted to
increase the exposure to vinca alkaloids.rTheoretical →
Also see TABLE 1 p. 1375 → Also see TABLE 9 p. 1377
▶ Miconazole is predicted to increase the concentration of vinca
vitamin D substances (colecalciferol).
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the exposure to vitamin D substances
slightly increases the exposure to zidovudine.
▶ Antifungals, azoles (fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure to zopiclone. Adjust
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the exposure to
Antihistamines, non-sedating → see TABLE 9 p. 1377 (QT-interval
▶ Since systemic absorption can follow topical application,
the possibility of interactions with topical azelastine
▶ Apple juice and orange juice decrease the exposure to
▶ Antacids decrease the absorption of fexofenadine. Separate
administration by 2 hours.nStudy
▶ Antiarrhythmics (dronedarone) are predicted to increase the
exposure to rupatadine. Avoid.oStudy
▶ Antiarrhythmics (dronedarone) are predicted to increase the
exposure to antihistamines, non-sedating (fexofenadine,
▶ Antifungals, azoles (fluconazole, isavuconazole, itraconazole,
ketoconazole, posaconazole, voriconazole) are predicted to
increase the exposure to rupatadine. Avoid.oStudy
▶ Antifungals, azoles (fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure to
▶ Antifungals, azoles (itraconazole, ketoconazole, voriconazole) are
predicted to increase the exposure to
▶ Antifungals, azoles (miconazole) are predicted to increase the
exposure to mizolastine. Avoid.oTheoretical
▶ Apalutamide slightly decreases the exposure to fexofenadine.
is predicted to increase the exposure to mizolastine.
▶ Aprepitant is predicted to increase the exposure to rupatadine.
▶ Antihistamines, non-sedating are predicted to decrease the
effects of betahistine.oTheoretical
▶ Calcium channel blockers (diltiazem, verapamil) are predicted to
increase the exposure to mizolastine.rTheoretical
▶ Calcium channel blockers (diltiazem, verapamil) are predicted to
increase the exposure to rupatadine. Avoid.oStudy
is predicted to increase the exposure to fexofenadine.
▶ Cobicistat is predicted to increase the exposure to mizolastine.
▶ Cobicistat is predicted to increase the exposure to rupatadine.
is predicted to increase the exposure to mizolastine.
▶ Crizotinib is predicted to increase the exposure to rupatadine.
▶ Eliglustat is predicted to increase the exposure to
fexofenadine. Adjust dose.oStudy
▶ Grapefruit juice slightly decreases the exposure to bilastine.
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