Conney, A. H., Pantuck, E. J., Pantuck, C. B., Buening, M., Jerina , D. M., Fortner, J. G.,

Alvares, A. P., Anderson, K. E. & Kappas, A. (1979). Role of environment and diet in the

regulation of human drug metabolism. In The Indu ction 01 Drug Metabo/ism, ed.

Estabrook, R. W. & Lindenlaub, E., pp. 583~05 Symposia Medica Hoechst 14.

Czygan, P., Greim, H., Garro, A. J., Hutterer, F., Rudick, J., Schaffner, F. & Popper, H. (1973).

Cytochrome P-450 content and the abilit y of Iiver microsome s from patients undergoing

abdominal surgery to alter the mutagenicity ofa primary and secondary carcinogen . J. Nat.

Cancer. lnst., 51, 1761-1764.

Drouillard, D. D., Vesell, E. S. & Dvorchik, B. H. (1978). Studies on theobromine disposition in

normal subjects. Clin. Pharmac. Ther., 23,296-302.

Eichelbaum, M., Spannbrucker, N., Steincke, B. & DengIer, H. J. (1979). Defective N-oxidation

ofsparteine in man: A new pharmacogenetic defect. Eur. J. clin. Pharmac., 16,183-187.

Harris, C. c., Autrup, H., Connor, R., Barrett, L. A., McDowell, E. M. & Trurnp, B. F. (1976).

VARIABILITY IN HUMAN DRUG MET ABOLlSM 61

Interindividual variation in binding of benzo[a]pyrene to DNA In eultured human

bronehi. Science.194, 1067-1069. Harris , C. c., Autrup, H., Stoner, G., Yang, S. K., Leutz, J. c.,Gelboin, H. V., Selkirk, J. K.,

Connor, R. J., Barrett , L. A., Jones , R. T., MeDowell, E. & Trump, B. F. (1977).

Metabolism of benzo[a]pyrene and 7,12-dimeth ylbenz[a]anthraeene in eultured human

bronehi and panereatie duct. CancerRes..37,3349-3355.

Harris, C. c.,Autrup, H., Trump, B. F., MeDowell, E. M., Apostolides, A. & Schafer , P. (1980).

Benzo[a]pyrene metabolism in cultured bronchi from patients with or without lung cancer.

Proc. Am. Ass. CancerRes.. 21, 117.

Huang, M. T., Chang, R. L. & Conney, A. H. (1980). Studies on the meehanism ofactivation of

microsomal benzo[a]pyrene hydrox ylase aeti vity by 7,8-benzoflavone. Fed. Proc.. 39,

2053 .

lber, F. L. (1977). Drug metabolism in heavy consumers ofethyl aIcohol. Clin. Pharmac. Ther..

22,735-742.

Jerina, D. M., Yagi, H., Thakker, D. R., Karle , J. M., Mah , H. D., Boyd, D. R., Gadaginamath,

G., Wood, A. W., Buening, M., Chang, R. L., Levin, W. & Conney, A. H. (1978). Stereoselective metabolie aetivation of polycyclic aromatie hydroearbons. In Advances in

Pharmacology and Therapeutics, vol. 9, Toxicology, ed. Cohen, Y., pp. 53-62. Oxford :

Pergamon Press.

Kappas, A., Alvares, A. P., Anderson, K. E., Pantuck, E. J., Pantuck, C. B., Chang, R. &

Conney, A. H. (1978). Effect of charcoal-broiled beef on antipyrine and theophylline

metabolism. Clin. Pharmac. Ther.. 23,445-450.

Kappas, A., Anderson, K. E., Conney, A. H. & Alvares, A. P. (1976). Influence of dietary

protein and carbohydrate on antipyrine and theophylline metabolism in man. Clin.

Pharmac. Ther.. 20,643-653 .

Kellermann, G. , Luyten-Kellermann, M. & Shaw, C. R. (1973). Genetic variation ofaryl hydroearbon hydroxylase in human Iymphocytes. Am. J. Human Genetics, 25,327-331.

Kolmodin, B., Azamoff, D. L. & Sjöqvist, F. (1969). Effect of environmental factors on drug

metabolism: Decreased plasma half-life of antipyrine in workers exposed to chlorinated

hydrocarbon inseetieides. Clin.Pharmac. Ther.. 10,638-642.

Kuntzman, R., Mark, L. c. Brand, L., Jacobson , M., Levin, W. & Conney, A. H. (1966).

Metabolism of drugs and carcinogens by liver enzymes. J. Pharmac. exp. Ther.. 152,

151-156.

Levin, W., Conney, A. H., Alvares, A. P., Merkatz, I. & Kappas, A. (1972). Induction of

benzo[a]pyrene hydroxylase in human skin . Science, 176,419-420.

Meredith, P. A., Campbell, B. C; Moore , M. R. & Goldberg, A. (1976). Antipyrine metabolism

in lead intoxication. Brit. J. clin. Pharmac., 3, 960 p.