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20

Depending on the location of the dissection, surgical intervention may be

required.

147,150 However, until a definitive diagnosis is made, the primary goal is to

reduce the BP and myocardial contractility to the lowest level compatible with the

maintenance of adequate renal, cerebral, and cardiac perfusion.

20 Aggressive BP

control is warranted to minimize target organ damage and to prevent further

dissection or hemorrhage.

146 For aortic dissection, it is suggested that the systolic BP

should be lowered to 100 to 120 mm Hg or a mean arterial pressure of less than 80

mm Hg within 5 to 10 minutes.

20

KEY REFERENCES AND WEBSITES

A full list of references for this chapter can be found at

http://thepoint.lww.com/AT11e. Below are the key references and websites for this

chapter, with the corresponding reference number in this chapter found in parentheses

after the reference.

Key References

Curran MP et al. Intravenous nicardipine: its use in the short-term treatment of hypertension and various other

indications. Drugs. 2006;66:1755. (127)

Grossman E et al. Should a moratorium be placed on sublingual nifedipine capsules given for hypertensive

emergencies and pseudoemergencies? JAMA. 1996;276:1328. (36)

Haas CE, LeBlanc JM. Acute postoperative hypertension: a review of therapeutic options. Am J Health Syst

Pharm. 2004;61:1661. (118)

Jauch EC et al; on behalf of the American Heart Association Stroke Council, Council on Cardiovascular Nursing,

Council on Peripheral Vascular Disease, and Council on Clinical Cardiology. Guidelines for the early

management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American

Heart Association/American Stroke Association. Stroke. 2013;44:870–947. (33)

Khoynezhad A, Plestis KA. Managing emergency hypertension in aortic dissection and aortic aneurysm surgery. J

Card Surg. 2006;21(Suppl 1):S3. (146)

Marik PE, Rivera R. Hypertensive emergencies: an update. Curr Opin Crit Care. 2011;17:569–580. (20)

Rodriguez M et al. Hypertensive crisis. Cardiol Rev. 2010;18:102. (3)

Key Websites

Barkis GL. Hypertensive Emergencies. Merck Manual Professional Version.

http://www.merckmanuals.com/professional/cardiovascular-disorders/hypertension/hypertensiveemergencies. Accessed October 12, 2015.

Erbel R et al. 2014 ESC Guidelines on the diagnosis and treatment of aortic diseases. European Society of

Cardiology. http://eurheartj.oxfordjournals.org/content/ehj/35/41/2873.full.pdf. Accessed October 12,

2015.

Jauch EC et al; on behalf of the American Heart Association Stroke Council, Council on Cardiovascular Nursing,

Council on Peripheral Vascular Disease, and Council on Clinical Cardiology. Guidelines for the early

management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American

Heart Association/American Stroke Association. American Heart Association/American Stroke Association.

http://stroke.ahajournals.org/content/44/3/870. Accessed October 12, 2015.

COMPLETE REFERENCES CHAPTER 16 HYPERTENSIVE

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