harmful, most manufacturers advise avoiding their use in
mothers who are breast-feeding.
Driving and skilled tasks Although drowsiness is rare,
nevertheless patients should be advised that it can occur
and may affect performance of skilled tasks (e.g. cycling or
driving); alcohol should be avoided.
l MEDICINAL FORMS There can be variation in the licensing of
different medicines containing the same drug. Forms available
from special-order manufacturers include: oral suspension, oral
CAUTIONARY AND ADVISORY LABELS 5
▶ Fexofenadine hydrochloride (Non-proprietary)
Fexofenadine hydrochloride 120 mg Fexofenadine 120mg tablets
| 30 tablet P £6.23 DT = £1.77
Fexofenadine hydrochloride 180 mg Fexofenadine 180mg tablets
| 30 tablet P £7.89 DT = £2.84
Fexofenadine hydrochloride 30 mg Telfast 30mg tablets | 60 tablet P £5.46 DT = £5.46
Fexofenadine hydrochloride 120 mg Telfast 120mg tablets | 30 tablet P £5.99 DT = £1.77
Fexofenadine hydrochloride 180 mg Telfast 180mg tablets | 30 tablet P £7.58 DT = £2.84
Levocetirizine hydrochloride 24-May-2017
Symptomatic relief of allergy such as hay fever, urticaria
▶ Child 6–17 years: 5 mg once daily
▶ Levocetirizine is an isomer of cetirizine.
l CONTRA-INDICATIONS Avoid in Acute porphyrias p. 1058
l INTERACTIONS → Appendix 1: antihistamines, nonsedating
▶ Common or very common Asthenia . constipation (in
children). drowsiness . dry mouth
SIDE-EFFECTS, FURTHER INFORMATION Non-sedating
antihistamines such as levocetirizine cause less sedation
and psychomotor impairment than the older
antihistamines, but can still occur; sedation is generally
minimal. This is because non-sedating antihistamines
penetrate the blood brain barrier to a much lesser extent.
l PREGNANCY Most manufacturers of antihistamines advise
avoiding their use during pregnancy; however, there is no
l BREAST FEEDING Most antihistamines are present in
breast milk in varying amounts; although not known to be
harmful, most manufacturers advise avoiding their use in
mothers who are breast-feeding.
▶ In adults Avoid if eGFR less than 10 mL/minute/1.73 m2
▶ In children Avoid if estimated glomerular filtration rate less
Dose adjustments ▶ In adults 5 mg on alternate days if
▶ In children Reduce dose frequency to alternate days if
estimated glomerular filtration rate
. Reduce dose frequency to every
3 days if estimated glomerular filtration rate
Driving and skilled tasks Although drowsiness is rare,
nevertheless patients should be advised that it can occur
and may affect performance of skilled tasks (e.g. cycling or
driving); alcohol should be avoided.
l MEDICINAL FORMS There can be variation in the licensing of
different medicines containing the same drug.
Levocetirizine dihydrochloride 500 microgram per 1 ml Xyzal
0.5mg/ml oral solution sugar-free | 200 ml P £6.00 DT = £6.00
▶ Levocetirizine hydrochloride (Non-proprietary)
Levocetirizine dihydrochloride 5 mg Levocetirizine 5mg tablets | 30 tablet P £4.45 DT = £3.05
Levocetirizine dihydrochloride 5 mg Xyzal 5mg tablets |
Symptomatic relief of allergy such as hay fever, chronic
▶ Child 2–11 years (body-weight up to 31 kg): 5 mg once daily
▶ Child 2–11 years (body-weight 31 kg and above): 10 mg
▶ Child 12–17 years: 10 mg once daily
l INTERACTIONS → Appendix 1: antihistamines, nonsedating
▶ Common or very common Drowsiness . nervousness (in
▶ Uncommon Appetite increased . headache (very common
▶ Rare or very rare Alopecia . angioedema . dizziness . dry
SIDE-EFFECTS, FURTHER INFORMATION Non-sedating
antihistamines such as loratadine cause less sedation and
psychomotor impairment than the older antihistamines,
but can still occur; sedation is generally minimal. This is
because non-sedating antihistamines penetrate the blood
brain barrier to a much lesser extent.
l PREGNANCY Most manufacturers of antihistamines advise
avoiding their use during pregnancy; however, there is no
l BREAST FEEDING Most antihistamines are present in
breast milk in varying amounts; although not known to be
harmful, most manufacturers advise avoiding their use in
mothers who are breast-feeding.
l HEPATIC IMPAIRMENT Manufacturer advises caution in
severe impairment (risk of increased exposure).
Dose adjustments Manufacturer advises initial dose
reduction to alternate days in severe impairment.
Medicines for Children leaflet: Loratadine for allergy symptoms
www.medicinesforchildren.org.uk/loratadine-allergy-symptoms
Driving and skilled tasks Although drowsiness is rare,
nevertheless patients and their carers should be advised
BNF 78 Allergic conditions 281
that it can occur and may affect performance of skilled
tasks (e.g. cycling or driving); alcohol should be avoided.
l PROFESSION SPECIFIC INFORMATION
Dental practitioners’ formulary
Loratadine 10 mg tablets may be prescribed.
Loratadine syrup 5 mg/5 mL may be prescribed.
l MEDICINAL FORMS There can be variation in the licensing of
different medicines containing the same drug.
EXCIPIENTS: May contain Propylene glycol
▶ Loratadine (Non-proprietary)
Loratadine 1 mg per 1 ml Loratadine 5mg/5ml oral solution | 100 ml P £1.90 DT = £1.55
Loratadine 5mg/5ml oral solution sugar free sugar-free | 100 ml P s
▶ Loratadine (Non-proprietary)
Loratadine 10 mg Loratadine 10mg tablets | 30 tablet p £1.44 DT
▶ Clarityn (Loratadine) (Bayer Plc)
Loratadine 10 mg Clarityn Allergy 10mg tablets | 60 tablet p
▶ Clarityn (Loratadine) (Bayer Plc)
Loratadine 10 mg Clarityn Rapide Allergy 10mg tablets sugar-free | 10 tablet G £3.24 DT = £3.24
Symptomatic relief of allergy such as hay fever, urticaria
▶ Child 12–17 years: 10 mg once daily
l CONTRA-INDICATIONS Cardiac disease . hypokalaemia . susceptibility to QT-interval prolongation
l INTERACTIONS → Appendix 1: antihistamines, nonsedating
▶ Uncommon Anxiety . arrhythmias . arthralgia . depression . myalgia . palpitations
▶ Rare or very rare Hypersensitivity
▶ Frequency not known Asthma exacerbated . bronchospasm . QT interval prolongation
SIDE-EFFECTS, FURTHER INFORMATION Non-sedating
antihistamines such as mizolastine cause less sedation and
psychomotor impairment than the older antihistamines,
but can still occur; sedation is generally minimal. This is
because non-sedating antihistamines penetrate the blood
brain barrier to a much lesser extent.
l PREGNANCY Most manufacturers of antihistamines advise
avoiding their use during pregnancy; however, there is no
l BREAST FEEDING Most antihistamines are present in
breast milk in varying amounts; although not known to be
harmful, most manufacturers advise avoiding their use in
mothers who are breast-feeding.
l HEPATIC IMPAIRMENT Manufacturer advises avoid in
Driving and skilled tasks Although drowsiness is rare,
nevertheless patients and their carers should be advised
that it can occur and may affect performance of skilled
tasks (e.g. cycling or driving); alcohol should be avoided.
l MEDICINAL FORMS There can be variation in the licensing of
different medicines containing the same drug.
CAUTIONARY AND ADVISORY LABELS 25
Mizolastine 10 mg Mizollen 10mg modified-release tablets | 30 tablet P £6.92 DT = £6.92
l DRUG ACTION Rupatadine is a second generation nonsedating antihistamine.
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